Naise (tablets) - instructions for use.

Dosage form

The drug is produced in 3 dosage forms - suspensions, dispersible and regular tablets. Suspension of a pleasant smell, with a shade of yellow color and quite characteristic for this drug taste. The suspension can be redispersed when the vial is shaken.

Tablets are produced in almost white color, with a slight yellowish tinge. Round tablets, biconvex, both of its surfaces are smooth.

Nyz composition:

Suspension

Active substance

• Nimesulide - 50 mg (in 5 ml of suspension)

Excipients:

• Sorbitol
• Glucose
• Xanthan gum
• Propylparaben
• Methylparaben
• Lemon acid
• Pineapple flavor
• Yellow dye WS
• Glycerol
• Polysorbate
• Purified Water

Dispersible tablets

Active substance

• Nimesulide - 50 mg (in 1 table)

Excipients

• Aspartame
• Calcium phosphate
• Microcrystalline cellulose
• Carboxymethyl starch
• Corn starch
• Talc
• Magnesium stearate
• Colloidal silicon dioxide
• Pineapple flavor

Pills

Active substance

• Nimesulide - 100 mg (in 1 table)

Excipients:

• Magnesium stearate
• Calcium phosphate hydrogen
• Microcrystalline cellulose
• Silicon anhydrous colloidal
• Corn starch
• Sodium starch glycollate
• Talcum purified

Pharmacological action of the drug

Pharmacological action refers primarily to nayz - tablets, the instruction contains data on all dosage forms. The drug is an NSAID containing a sulfonylidic moiety in its structure. Nimesulide, possibly, belongs to inhibitors of COX-2, as a result of which it has anti-inflammatory and analgesic effects, in addition, the drug has analgesic effects, but to a lesser extent.

The mechanism of action of the drug is associated with the suppression of the synthesis of prostaglandins in the inflammatory region, as well as suppression of the formation of oxygen radicals and inhibition of the release of myeloperoxidase.

Pharmacokinetics

Nyz is excellently absorbed from the digestive tract, reaching its maximum in the blood after 2 hours. The drug is 99% bound to proteins.

The drug Nise - tablets, instruction about which is taken from official sources, is metabolized in the liver, and is excreted from the body with urine, and 98% of the received dose is excreted within 24 hours.

Indications

• Rheumatic diseases that develop outside the joint capsule
• Osteoarthritis
• Inflammation and pain after surgery
• Pain caused by dysmenorrhea
• Fever and pain during acute inflammation in the upper respiratory tract

Side effects naz

Tablets, the instruction to which is now given, can give side effects in various systems and organs:

Side effects of the drug, which are related to the digestive tract

• Nausea
• Heartburn
• Pain in the stomach
• Tarry stools

Side effects of the drug, which are related to the central nervous system:

• Headache
• Drowsiness
• Dizziness

Side effects of the drug, which are allergic reactions:

• Erythema
• Skin rash
• Hives

Other side effects:

• Delay in the body fluid
• Oliguria
• Edema

Nayz contraindications

A list of contraindications is given in which it is recommended to avoid taking the drug, and if necessary, only after consulting a doctor.

• Bleeding from the digestive tract
• Renal insufficiency
• Liver failure
• Pregnancy and lactemia
• Peptic ulcer of the gastrointestinal tract

Drug Interactions Nase

Tablets, the instruction on the use of which does not give complete and exhaustive data on all drug drug interactions, reads as follows: it is not recommended to use together with the following drugs: phenytoin, digoxin, any diuretics, lithium preparations, anticoagulants, antihypertensive drugs, other NSAIDs, methotrexate, cyclosporine .