"Dipyridamole": instructions for use. "Dipyridamole": reviews and analogues

What is the drug "Dipiridamol"? The instruction, price, properties and indications of this tool will be presented further. Also we will tell you about whether it is possible to take the said drug during pregnancy, whether it has analogs, side reactions and contraindications.

Composition, packaging and shape

What does the instruction for use tell about the preparation? "Dipiridamol" is a medicinal product that has several forms of release. Let's consider them in more detail:

• Dragee by 0,075 and 0,025 g. The active substance of this form is dipyridamole. The drug is sold in plastic packages of 100 pieces.
• "Dipiridamole" - tablets of 0,075, 0,005 and 0,025 g. Coated, they also contain an active substance such as dipyridamole. As for the auxiliary elements, they include calcium stearate, lactose monohydrate and starch. The medication goes on sale in cellular packages of 120 or 40 pieces, which are placed in packs of cardboard.
• Injection. This form includes a similar active ingredient. 0.5% solution is sold in ampoules of 2 ml.

Pharmacodynamics

What are the properties of the medication in question? What does the attached instruction for use say about this? "Dipiridamol" - a drug that has a vasodilating effect. This effect is mainly on the coronary vessels.

The accepted dosage of the drug inhibits the adhesion of platelets, increases the speed of blood flow, improves microcirculation and has an angioprotective effect. In addition, the agent under consideration promotes collateral circulation in the blood vessels of the heart.

One can not help saying that this drug normalizes venous outflow. Therefore, his regular intake significantly reduces the risk of thrombosis, especially in the postoperative period.

Operating principle

What other properties does the "Dipiridamol" medication have? The instruction says that this remedy lowers the tone of the brain vessels. In this regard, it is quite actively used in transient ischemic attacks. In addition, this drug significantly improves placental circulation. This property helps to prevent fetal hypoxia.

What is the mechanism of action of the drug? What information does the instruction manual contain? "Dipiridamol" increases the activity of adenosine, and also reduces its capture by tissues. This substance affects the musculature of the vessels, blocking the release of norepinephrine, which, in fact, causes their constriction, raising the OPSS and blood pressure.

It should also be said that as a result of blocking phosphodiesterase, release of aggregation activators from platelets is reduced. This property prevents their gluing. In this case, a decrease in the adhesiveness of platelets does not allow the formation of clots in the vessels.

The drug "Dipiridamol", the price of which is indicated below, as a disaggregant is often used in conjunction with acetylsalicylic acid.

Pharmacokinetics

Absorbed means considered rather quickly. Its maximum concentration is achieved approximately 60 minutes after ingestion.

Accumulation of the active substance is carried out in myocardiocytes. The drug is metabolized in the liver. If the work of this body is disrupted, cumulation is possible.

Indications for use

Medication "Dipiridamol" is prescribed for the following diseases:

• Coronary insufficiency of a chronic nature;
• For prevention of occlusion of shunts and stents;
• Attacks of angina pectoris;
• Myocardial infarction (only not in acute stage);
• Venous, as well as arterial thrombosis;
• Ischemic stroke;
• Prevention of thromboembolism, especially after surgical interventions on the heart;
• Insufficiency of placental;
• Encephalopathy discirculatory;
• Atherosclerosis of the vessels of the legs;
• Disorders of microcirculation of any origin;
• Glomerulonephritis;
• DIC-syndrome in a child with sepsis and toxicosis.

Contraindications for use

According to the instruction, the tool in question can not be used in the presence of the following deviations:

• Arterial hypotension ;
• Unstable angina;
• Acute myocardial infarction;
• Hypersensitivity;
• Severe forms of arrhythmia;
• Decompensated CHF;
• Hepatic insufficiency;
• Hemorrhagic diathesis;
• Stomach ulcer, especially with a tendency to bleeding.

Also it should be said that this medication is prescribed with special care to children under 12 years of age and during lactation. In addition, you can not use the drug intravenously during collapse.

Instructions for use

"Dipiridamol" is an antithrombotic drug, which should be prescribed only by the attending physician.

As a rule, tablets and pills are taken orally 60 minutes before a meal, with a glass of water. In order to reduce the irritating effect on the gastric mucosa, this medication can be drunk with warm milk.

Dosage and methods of application of the drug should be determined only by the doctor, depending on the patient's age, indications and the state of his health.

For the prevention of thrombosis appoint 75 mg of the drug 6 times a day (the maximum dose per day - 300-450 mg).

When coronary insufficiency is used 25-50 mg of the drug three times a day. The maximum dose for this condition is about 150-200 mg.

In order to prevent thrombosis of the shunts and stent, the patient is given 50 mg of the agent (four times a day) together with acetylsalicylic acid. The medication is used before the operation, and also within a week after it.

When obliterating vascular diseases of the lower extremities are recommended to take 75 mg of medication three times a day.

The daily dosage of the drug for children depends on their weight (5-10 mg per kg).

According to the instruction, during treatment it is necessary to limit the use of tea and coffee, since they can weaken the action of the medicine.

Overdose

When using higher doses of medication, the patient may experience the following symptoms: lower blood pressure, dizziness, increased bleeding and palpitations. In this case, it is necessary to cancel the drug and contact the doctor.

Adverse Reactions

According to reviews of patients, in some cases, the taking of the drug in question can cause the following side effects:

• Allergic reactions;
• cardiopalmus;
• Decreased blood pressure (especially with intravenous administration);
• Thrombocytopenia;
• headache;
• Dyspeptic disorders;
• Noise in the head;
• Hyperemia of the face;
• tachycardia;
• Increased bleeding or bleeding.

Drug Interactions

The antiaggregant effect of this drug is enhanced by simultaneous administration with acetylsalicylic acid, tetracycline, penicillin, cephalosporin, indirect anticoagulants and nicotinic acid.

It should also be noted that indirect anticoagulants, thrombolytics and heparin may increase the likelihood of hemorrhagic complications.

It is impossible not to say that caffeine-containing drugs and xanthines reduce the vasodilating and antithrombotic effects of the drug in question, and antacids reduce its absorption and reduce the concentration in the blood.

As for the drug itself, it enhances the effect of antihypertensive drugs.

Can I use the drug "Dipiridamol" during pregnancy?

Experts argue that against the background of taking the drug under consideration, pregnant women do not experience complications. Conversely, the drug "Dipiridamol" during pregnancy is often prescribed, if there is a threat of miscarriage or fetoplacental insufficiency.

Prices and Analogues

What can replace the drug "Dipiridamol"? Analogs of this tool are listed below. These include the following drugs: Parsedil, Kurantil, Padicor, Antisthenocardine, Trancocord, Stenocardilus, Persanthin, Dipiridamol-Ferein. All listed drugs have the same active substance. However, they may have different side effects and contraindications. In this regard, use these funds is recommended only after consulting a doctor.

How much is the drug "Dipiridamol"? Its price fluctuates between 380-420 rubles (depends on the amount and form of release of the medicine).

Reviews

Most often, patients who are prescribed to prevent and treat premature aging of the placenta, as well as fetoplacental insufficiency leave their comments about this drug.

It should be noted that pregnant women tolerate such a drug quite well. Only some of the fair sex have side effects in the form of lowering blood pressure and dizziness.