"Aminofillin": instructions for use, analogues

How should I use Aminophylline? Instructions for use, analogues and characteristics of this tool will be discussed further.

Composition and forms

What does the "Aminophylline" medication contain? Instructions for use asserts that the active element of this agent is the same substance - aminophylline.

The drug goes on sale in the form of a solution for intravenous administration, as well as in the form of tablets, cream or ointment.

Pharmacological features

What is a remedy like Aminophylline? Instructions for use (in ampoules this drug can be purchased at any pharmacy) reports that it is a vasodilating, spasmolytic, diuretic and bronchodilating medicine.

The active element of this medication is the ethylenediamine salt of theophylline. It has bronchodilator and bronchodilator effect, which is due to its direct relaxing effect on the smooth muscle fibers of the vessels of the lungs and respiratory tract. This effect is caused by selective suppression of phosphodiesterase activity, which leads to an increase in the intracellular content of cAMP.

Properties of the medicine

What is remarkable about "Aminophylline"? The instruction for use states that it is able to reduce the hyperreactivity of the respiratory tract. The mechanism of this action is still unknown, but experts argue that the use of this drug causes an increase in the number and activity of T-suppressors in the blood.

Increasing the mucociliary clearance, strengthening the contraction of the diaphragm, and also stimulating the work of the intercostal respiratory muscles, this means activates the respiratory center, contributing to its sensitivity, and enhances the alveolar ventilation, which ultimately leads to a decrease in the incidence and severity of episodes of apnea.

How else does the drug "Aminophylline" work? Instructions for use (ointment and solution have the same effect on the body) reports that the agent under consideration regulates the respiratory function, which improves the O2 blood saturation and lowers the concentration of carbon dioxide. In addition, this medication is able to stimulate the ventilation of the lungs with hypokalemia.

It should also be noted that "Aminophylline", the instruction for which is described below, activates the work of the heart, increases the frequency and strength of the heart, increases the need for cardiac muscle in O ₂ and significantly increases the cardiac blood flow.

The use of this drug helps reduce the tone of the vessels of the brain, kidneys and skin. Experts argue that the agent under consideration has a diuretic and peripheral veno-expansive action, reduces the resistance of the vessels of the lungs, lowers the pressure in the pulmonary circulation and stimulates blood flow in the kidneys. Also, this drug expands the biliary tract, slows down the adhesion of platelets and the release of mediators of hypersensitivity reactions, stabilizes the walls of mast cells, regulates microcirculation, reduces the risk of thrombosis and increases the stability of red blood cells.

In large doses, the drug in question exhibits epileptogenic properties.

Kinetics

What kinetic parameters are characteristic for the "Aminophylline"? Instructions for use (for losing weight this drug is used quite often) says that after getting into the human body the active element of this drug is metabolized with the subsequent release of unbound theophylline, which subsequently binds to plasma proteins by 40%.

The agent under consideration is able to penetrate the placental barrier and also be excreted along with the mother's milk.

The transformation of theophylline occurs in the liver with the participation of the enzyme cytochrome P450.

In its original form, the drug is excreted at 10% with urine. The half-life of this remedy for non-smokers, as well as for patients suffering from bronchial asthma, is 12 hours, for children 1-5 hours, for newborns - up to 2 days, and for smokers - 4 hours.

When appoint?

Indications for the use of this drug depend on the form of its release.

Parenteral administration is recommended when:

• Ischemic impairment of cerebral circulation;
• Asthmatic status ;
• Failure of left ventricular, which was complicated by a respiratory disorder and bronchospasm;
• Apnea of newborns;
• Chronic and acute heart failure;
• Edema of kidney origin.

In what cases do you use "Aminophylline" (tablets) orally? The instructions for use indicate that this remedy is well manifested in the pulmonary heart, bronchial obstructive syndrome of different etiology (for example, emphysema, bronchial asthma, COPD, obstructive bronchitis), nocturnal apnea, increased pressure in pulmonary circulation, cardiac failure in chronic or acute type .

Contraindications

When should you not use the drug "Aminophylline"? Instruction for use informs that it is contraindicated for:

• Severe arterial hypertension or hypotension, tachyarrhythmia, gastrointestinal tract ulcer, including in the exacerbation phase;
• Hyperacidity gastritis, severe impairment of renal or hepatic function, hemorrhagic stroke, epilepsy, haemorrhage in the retina of the eye;
• Simultaneous use with ephedrine in children under 3 years of age, hypersensitivity to aminophylline or theophylline.

The preparation "Aminofillin": instructions for use

From cellulite (reviews of patients will be discussed below) this tool helps quite well, however this is not the main purpose of the drug in question.

How should I use it? The scheme of taking this medication is individual. Treatment is developed by an experienced physician depending on the clinical picture, the patient's age, indications and the presence of nicotine addiction.

The drug in the form of a solution can be administered intramuscularly or intravenously, and in the form of an ointment - applied to dry and nerazdrazhennuyu skin.

How to apply for weight loss?

Is it possible to use Aminophylline medication to reduce weight? Instructions for use (from cellulite, this drug is most often used in the form of ointment) does not contain any information on this account. However, experts argue that the active substance of this drug actually helps to reduce body weight, as well as partially get rid of the effect of the "orange peel". How does this happen? The fact is that aminophylline is able to increase blood circulation in tissues, and also to improve their drainage function. This substance is found in many creams from cellulite (for example, Turboslim, Draine Minceur, Reflexe Minceur, Phyto-Complexe, Shape-up and others).

Schemes of ointments with aminophylline depend on their total composition and manufacturer.

Side effects

What side effects can occur when using the drug in question? According to the instruction, it is able to cause:

• Sleep disturbances, anxiety, dizziness, convulsions and tremors;
• Gastroesophageal reflux, vomiting, diarrhea, nausea, heartburn, anorexia and exacerbation of peptic ulcer;
• Heart rhythm disturbances, pain in the heart, aggravation of angina pectoris, pressure decrease, cardialgia and tachycardia;
• Hematuria, albuminuria;
• Itching, fever and rash;
• Hypoglycemia;
• Hyperemia, tenderness and denseness in the area of injection;
• Tachypnea, albuminuria, chest pain, hematuria, hot flashes, hypoglycemia, increased sweating, and increased daily diuresis.

Interaction and overdose

Until now, there have been no reports of overdose by this agent. If this condition occurs, then stop taking the medication and begin symptomatic treatment.

When the drug is taken in parallel with sympathomimetics, their pharmacological action is mutually activated. As for beta-blockers and lithium agents, the effect is mutually weakened.

The therapeutic effect of "Aminophylline" is markedly reduced when it is used simultaneously with "Phenobarbital", "Rifampicin", "Isoniazid", "Carbamazepine", "Sulfinpirazone", "Phenytoin" (including smokers).

The effect of the drug in question may be increased by co-administration with quinolones, lincomycin, macrolides, cimetidine, allopurinol, isoprenaline, beta adrenoblockers, fluvoxamine, oral contraceptives, disulfiram, and viloxazine, and during influenza vaccination .

Enterosorbents and antidiarrhoeals reduce adsorption of "Aminophylline".

Analogues and consumer reviews

Are there any analogues of Aminophylline? Experts answer this question in the affirmative. The medicine in question can be replaced by "Aminophylline-Escom", "Eufillin-Darnitsey", tablets and injections of "Eufillina".

What do consumers say about the facility mentioned? There are a lot of reviews about this product. Most patients report that the injection solution of "Aminophylline" is a proven tool. Its effectiveness and efficacy do not cause any doubts, including when attacks of bronchial asthma.

As for the reviews on the cream "Aminophylline", then they are contradictory. Some consumers argue that this tool is ineffective. However, there are also such patients who share impressive results after applying ointment against cellulite.