"Дайвонекс" at a psoriasis - responses. Hormonal drugs in the treatment of psoriasis

How should I use Daevonex in psoriasis? You will find comments about this medication in the materials of the article. Also, we will tell you about the form in which this product is manufactured, what is included in its composition, how much it costs, what properties it possesses, and so on.

Composition, packaging, form of release

What should I use the Daivonex formulations for psoriasis? Reviews say that this product is available in three different forms. Consider their composition and packaging in more detail.

• "Daivonex" - ointment, the active ingredient of which acts calcipotriol. As additional ingredients, the preparation contains paraffin liquid, propylene glycol, water, macrogol stearate, trilon B, soft white paraffin, α-tocopherol and sodium hydrogen phosphate dihydrate. In the sale of such a tool can be found in tubes of aluminum for 100 and 30 g.
• "Daivonex" is a cream, the active ingredient of which is calcipotriol in the form of monohydrate. Also, the preparation contains prepared water, glycerin, paraffin liquid, sodium hydroxide, cetearyl alcohol, soft white wax, macrogol cetostearate, sodium hydrogen phosphate hydrate, trilon B and chloroallylmetamene chloride. In the sale of such a product comes in tubes of aluminum for 100 and 30 g.
• "Daivonex" is a solution, active ingredient of which is calcipotriol in the form of monohydrate. As additional components, propylene glycol, prepared water, HPC, levomenthol, isopropanol and sodium citrate are used. In the sale of this form of the drug comes in a vial of 60 ml polyethylene.

Pharmacological action of the drug

How does the drug "Daivonex" with psoriasis? Experts say that its active substance - calcipotriol - is an analog of the active metabolite of vitamin D. It is he that inhibits the activation of T lymphocytes, which is caused by interleukin 1.

The therapeutic effect of the drug is due to the stimulation of morphological differentiation, as well as the suppression of the proliferation of keratinocytes.

Specialists claim that calcipotriol has a very weak effect on calcium metabolism, compared with calcitriol.

Features of the external preparation "Daivonex"

Is the "Davynex" hormone medication? The instruction, attached to this remedy, states that, in contrast to the drug "Daivobet", the agent in question is not hormonal.

The peculiarity of this medication is that it suppresses the growth of epidermal cells, the excessive growth of which is the cause of the appearance of psoriasis.

As practice shows, the drug under consideration manifests its effectiveness after about one to three weeks of active use.

Pharmacokinetic properties of the external agent

Is the absorption of the drug "Daivonex"? The instruction says that its active substance is absorbed by about 1-5% and undergoes biotransformation in the liver. After that in the patient's body, inactive metabolites are formed.

The half-life of the drug is rather short.

Indications for the use of ointment, cream and solution

What is the use of the medicine "Daivonex", the price of which is indicated below? Most often this drug is prescribed for monotherapy of such a disease as psoriasis, including that form that affects the scalp.

There are patient reviews that indicate that both fixed and regressive forms of the disease are susceptible to treatment with this drug.

In addition, this medication is often used for the complex treatment of skin disease together with such drugs as "Acitretin", "Ciclosporin" and corticosteroids.

By the way, the solution of "Daivonex" (lotion) is used only in areas with the presence of hair.

Contraindications for use

What are the contraindications for the drug "Daivonex"? Ointment and cream should not be used in the following cases:

• With diseases accompanied by a violation of calcium metabolism;
• In adolescence and childhood (up to 18 years);
• With hypersensitivity to calcipotriol, as well as other components of the drug.

As for the solution, it also has its own contraindications. It can not be used when:

• Hypercalciuria;
• Hypersensitivity to the elements of the remedy;
• Hypervitaminosis D;
• Nephrolithiasis;
• Hypercalcemia.

It is impossible not to say that the agent under consideration with special caution is prescribed for patients with:

• Nephrolithiasis;
• Hepatic insufficiency;
• Acute renal insufficiency;
• Aged over 60 years.
  

Instructions for the use of external means

How is Daivonex used in psoriasis? Reviews of this remedy state that the cream and ointment should be applied to affected areas twice a day.

The acceptable amount of cream is no more than 15 g per day, or 100 g per week.

Ointment "Дайвонекс" it is undesirable to appoint to children and teenagers till 18 years. But if absolutely necessary, when other drugs are ineffective, they are still being used. A child of 6-12 years of age is given medication twice a day. The maximum weekly dosage for this age is 50 g.

Adolescents after 12 years are allowed to use a weekly dosage equal to 75 g.

Therapy with "Daivonex" in children should be short. Moreover, the medicine should be applied to a small area of the skin (not more than 30% of the total surface area of the body).

The drug in the form of a cream for the treatment of psoriasis is used no longer than 7-8 weeks, but in the form of an ointment is used up to a year.

As mentioned above, the "Daivonex" solution is used mainly for the treatment of a disease that has manifested itself on the scalp. A peculiar lotion is applied to the affected areas twice a day and rubbed gently.

Up to 60 ml of solution can be used per week. Complex treatment is also possible. It provides for the combination of "Daivonex" cream and solution. It should be borne in mind that a weekly dosage should not exceed 5 mg (ie 30 ml of solution and 60 g of cream or 30 g of ointment and 60 ml of solution).

Overdose

What symptoms of overdoses occur when the recommended doses of "Daivonex" are exceeded? Analogues and the self-described remedy in high doses can lead to an increase in the concentration of calcium in the blood. Against this background, the patient is thirsty, there is a decrease in the tone of muscle tissue, constipation, reduced concentration and fatigue.

When these signs appear, you should immediately stop using the medication.

Adverse Reactions

There are quite a few side effects that can occur when using a cream, ointment or a solution of Daivonex. The following reactions are most often manifested:

• Swelling of the face;
• Allergic reactions (dermatological);
• Depigmentation, which is reversible;
• Hypercalcemia;
• Periorbital edema;
• Contact dermatitis;
• erythema;
• Irritation of the skin in the place of application of ointment, cream or lotion;
• Hyperpigmentation of reversible character;
• Various types of rashes;
• Peeling of the skin;
• Burning of the skin;
• Itching;
• Edema angioedema;
• eczema;
• Exacerbation of the psoriatic process;
• Dry skin;
• Hypercalciuria;
• Photosensitization.
  

To eliminate such symptoms, the patient should increase fluid intake. Also, with the appearance of adverse reactions, the patient is hemodialysis (if there is kidney failure), forced diuresis, and also give corticosteroids and potassium chloride. At the same time constantly monitor the daily volume of urine and the level of electrolytes.

Drug Interactions

The preparation "Дайвонекс" is forbidden to use simultaneously with medicines in which structure enters salicylic acid, and also its derivatives.

Special instructions for using the product

Before using any form of "Daivonex" preparation, it is necessary to familiarize yourself with the attached instructions. It states that:

• It is highly not recommended to apply the cream on the face. To avoid this contact, after each use of the drug, the hands should be thoroughly washed using soap.
• Do not apply Daivonex to large areas of the skin (more than 30%). If this need arises, the concentration of calcium in urine and blood should be monitored regularly.
• Hypercalcemia usually develops when using higher doses of the drug. When it is abolished, the calcium concentration quickly normalizes.
• The cream contains in its composition a component such as cetostearyl alcohol. This substance can easily cause a rash.
• During the use of the drug, patients should avoid excessive exposure to artificial or natural sunlight.
• The active substance of the preparation has no effect on the ability of a person to control complex mechanisms or vehicles.

"Daivonex" medication: analogues and price

The most popular and effective analogues of the drug under consideration are such drugs as "Daivobet", "Glenriaz" and "Psorkutan". Before using these medications, you should always consult a dermatologist.

How much is the drug "Daivonex"? The price of this product depends on the form of its release and volume. The average cost of the drug in Russia is from 800 to 1200 rubles.

Reviews about the drug

According to reviews of a drug such as "Daivonex," it does not help with psoriasis in all cases. In this regard, ointment, cream or solution should be used only for the purpose of a specialist (that is, a dermatologist).

It should also be noted that most experts, however, note that the medicines "Daivonex" and "Daivobet" are the main tools that are actively used to treat vulgar psoriasis.