"Itomed": analogues, instructions and references

"Itomed" - a drug that affects the digestive tract. The drug improves motor and tone of the gastrointestinal tract. The drug has a pronounced antiemetic effect.

Components of the drug, form of release

The drug is made on the basis of tiotropide, is available in the form of tablets. The dosage of the active substance in one tablet is 50 mg. Tablets can be purchased in packages of 40 and 100 pcs. The auxiliary components are acid silicic anhydrous, hypromellose, lactose, macragol 6000, corn starch, magnesium stearate, carnauba wax, titanium dioxide and carmellose. In cases where a person does not fit "Itomed", similar drugs are selected by a specialist, but with a different composition.

Pharmacological action, pharmacokinetics

The drug refers to antacid enveloping agents. The drug also has antiulcer action, does not change the level of gastrin. GI motility is increased due to antagonism with D2-dopamine receptors and inhibition of acetylcholinesterase.

The drug promotes the release of acetylcholine, protects it from destruction. Antiemetic action develops as a result of interaction with D2-dopamine receptors, which are located in the trigger zone.

After the use of tablets, a dose-dependent suppression of vomiting is achieved, the appearance of which is provoked by "Apomorphine".

The use of the drug positively affects the work of the upper gastrointestinal tract, thanks to the use of this agent, transit through the stomach is accelerated, and the process of its emptying is being established. The analogs used in place of "Itomed" have a similar effect.

Absorption of the drug in the gastrointestinal tract occurs quickly, bioavailability is approximately 60%. In order to maximize the concentration of the drug in the blood, it takes from 30 to 45 minutes. Accumulation of the agent in the body is minimal. Link with proteins: with albumin - 96%, with alpha acid glycoprotein - about 15%.

The medication is well distributed in the tissues, gets into the small intestine, stomach, adrenals, liver, kidneys. "Itomed" is found in the composition of breast milk, its insignificant amount is found in the spinal cord and head. Metabolic processes occur in the liver, the drug is excreted by the kidneys, partial excretion occurs within six hours, with trimethylaminuria longer.

Indications, contraindications

"Itomed", analogs are prescribed when it is necessary to treat non-ulcer dyspepsia, which is accompanied by a chronic gastritis. The drug is indicated with bloating, the presence of nausea with the development of vomiting, with heartburn and pain in the stomach. If patients have abdominal discomfort, especially in the epigastric region, also appoint "Itomed", its appointment is possible and with anorexia.

Tablets are not taken with increased sensitivity to their components, with bleeding in the intestines and stomach. Contra-indications also include glucose-galactose malabsorption, lactose intolerance, lack of lactase. It is forbidden to use the drug for children less than sixteen years old, pregnant and breast feeding women. Analogues of "Itomed" can be matched with perforation of the digestive tract and mechanical obstruction.

Special treatment conditions are required for patients who take m-cholinomimetics and cholinoesterase inhibitors, elderly patients with kidney and liver disorders.

Application of the drug, dosage

The medication is taken daily before meals at a dose of 150 mg, that is, a three-time tablet is required, 50 mg at a time. Elderly, the dose of the drug is reduced. In cases where it was not possible to drink the tablet on time, further use of the drug should be performed at equal intervals. You can not double the dose.

Adverse events

There may be side effects after taking the drug "Itomed". The instruction of analogues recommends appointing, if this medicine is not suitable for the patient. Undesirable reactions can develop from the digestive, nervous and endocrine systems. Some patients develop allergic reactions, laboratory parameters change temporarily. Possible violations in the immune system and reproductive. Excessive metabolic processes and skin lesions may occur. Also, adverse events include changes in the hematopoiesis system.

Overdosage is eliminated by washing the stomach and implementing symptomatic therapy. In such cases, to continue treatment, you can designate analogues instead of the Itomed tool.

special instructions

If the patient has signs of gynecomastia and galactorrhea, the therapy is temporarily stopped or transferred to another drug. The use of "Itomed" in the treatment of cirrhosis of the biliary (primary) can lead to a passing decompensation of cirrhosis, this state disappears on its own after the drug is withdrawn. It is necessary to temporarily abandon the performance of important tasks, in which increased attention and quick psychomotor reactions are necessary, during the treatment with the drug "Itomed". Analogues, substitutes are selected together with a specialist, if necessary.

"Itomed" leads to a faster absorption of other drugs. The effect of using the medication does not deteriorate as a result of taking drugs, whose action is aimed at reducing the acidity of gastric juice. The effect is less pronounced with the simultaneous use of the drug with m-holinoblokatorami, with the combination of the drug with inhibitors of cholinesterase, m-cholinomimetics, the effect of taking tablets "Itomed" is more pronounced. Analogues can manifest themselves otherwise in such cases.

Analogues, reviews

When it is necessary to replace the drug, this issue is discussed with a specialist. Often, as a substitute, doctors prescribe "Itopride" and are treated with the drugs "Itopra" or "Ganaton". These analogues of "Itomed" have in their composition the same active substance.

Domestic drug substitutes are also produced. There are analogues (Russia) for the agent "Itomed", such as "Ceruglan", "Gastrica-GF".

Despite the fact that "Itomed" patients are treated for a long time, there is little feedback about its use. Usually taking the drug for six to eight weeks leads to the elimination of flatulence, reduces the appearance of heartburn, leads to the disappearance of gravity in the stomach and the appearance of appetite. Patients consider the drug effective and with chronic constipation. The reviews show a good tolerability of the medication and the absence of serious side effects. Most often, diarrhea develops, headache and pain in the abdomen are present. The reviews show that the drug can lead to the development of amenorrhea. However, all individually and the action of "Itomed" may differ, so as not to have serious consequences, the treatment should be prescribed by a doctor.