The drug "Tizanidine": instructions for use, synonyms. "Tizanidine-Teva", "Tizanidine-Ratiofarm"

In what dosages do you prescribe the drug "Tizanidine"? Instructions for using this medication are provided below. Also, from the materials in this article, you will find out in what form the mentioned remedy is made, what is included in its composition, whether it has side reactions, analogues and contraindications.

Form, description, composition

What is the composition of tizanidine? Instructions for use say that the active component of this drug is tizanidine. Also, the composition of the medicament in question includes auxiliary substances in the form of anhydrous lactose, colloidal silicon dioxide, microcrystalline cellulose and stearic acid.

The drug "Tizanidin", the instruction of which is enclosed in a cardboard package, is made in the form of round tablets of white color. On one side of the medicine there is a separation strip, and on the second side there is a marking T4 or T2.

Pharmacological features

What is the mechanism of action of the drug "Tizanidine"? Instructions for use indicate that it is a muscle relaxant. After taking the tablets inside the active substance of the drug helps to reduce the tone of skeletal muscles, reduce their resistance in passive movements, as well as inhibition of spasmodic reactions and enhance arbitrary abbreviations.

From the foregoing, it can be safely noted that the drug in question contributes to the muscular-relaxing effect. This is due to the inhibition of polysynaptic spinal reflexes. This effect is due to the release of amino acids from the terminals (presynaptic) spinal interneurons.

Pharmacokinetic parameters

What pharmacokinetic parameters does the drug "Tizanidine" (tablets) have? The instruction on the application gives an exhaustive information on this.

After oral administration, the medication is absorbed completely. Its absolute bioavailability is about 40% (due to extensive first passage through the liver).

The active substance of the drug is distributed to all systems and tissues. Its relationship with proteins is about 30%.

The half-life of the drug is 2.5 hours. About 95% of the dose taken is metabolized. The drug is given by the kidneys (about 60%) and the gastrointestinal tract (about 20%).

Indications for use

In what cases is the drug "Tizanidine" prescribed? The use of this drug is most effective in the spastic condition of skeletal muscles, which is observed with such neurological diseases as:

• stroke;
• Degenerative pathologies of the spinal cord;
• Chronic myelopathy;
• multiple sclerosis.

Also, the medication "Tizanidine" is indicated for muscle pain that develops due to a spinal injury.

Contraindications for use

The main and, perhaps, the only contraindication of this drug is the hypersensitivity of the patient to tizanidine. Also it is forbidden to take it together with such means as "Ciprofloxacin" and "Fluvoxamine".

The preparation "Tizanidine": instructions for use

According to the instructions, the initial dosage of the drug "Tizanidine" should be 2 mg.

In view of the fact that the effect of taking the drug reaches its peak after 1-2 hours and dissipated after 3-6 hours, treatment should be done at intervals of 6-8 hours. Thus, during the day should take no more than 3 tablets.

The dosage of the drug is gradually increased to 4 mg (per dose). However, they do this only if, after 4 days, the result of treatment has not been shown.

The total daily dosage of the drug should not be above 36 mg. As for single doses, the intake of more than 16 mg by specialists has not been studied.

• With renal failure. With this diagnosis, tablets are administered with extreme caution.
• Disturbances in the liver. The drug "Tizanidine" with caution is recommended to people who have any form of liver failure. In such patients, individual dosages should be reduced. It is necessary to constantly check the level of aminotransferase. The first monitoring is performed one month after the start of treatment.

Cases of overdose

Clinical symptoms that occur against a background of overdoses may have completely different pharmacology. In most cases, patients experience lethargy, confusion, drowsiness, and coma. In addition, taking the drug in large doses can cause dysfunction of the heart muscle, including the emergence of bradycardia and hypotension.

Adverse events

Are there side effects when taking Tizanidine? Instructions for use (synonyms of this agent are indicated below) states that the medication in question can cause dry mouth, drowsiness, hypotension, bradycardia, decreased blood pressure, dizziness, muscle spasms, asthenia, weakness, fatigue, hallucinations, hepatotoxicity, liver disorders.

Very rarely, treatment with this drug contributes to the emergence of Stevens-Johnson syndrome, exfoliative dermatitis, anaphylactic shock, ventricular tachycardia, hepatitis, depression, seizures, joint pain, rash, paresthesia and tremor.

Drug Interactions

Before using Tizanidine, you should carefully read the instructions. It identifies the following features of its drug interaction:

• When combined with "Ciprofloxacin" and "Fluvoxamine", blood pressure may decrease significantly, and drowsiness may develop. In addition, such a complex of drugs violates human psychomotor functions.
• Simultaneous administration of the drug with inhibitors of CYP1A2 (for example, Zileiton, Fluoroquinolone, Amiodarone, Mexiletin, Propafenone, Verapamil, Cimetidine, Famotidine, Acyclovir and Ticlopidine) is strictly Is contraindicated.
• It is not recommended to combine tablets of "Tizanidine" with oral contraceptives. If the patient's current condition requires simultaneous administration of these medications, then the dosage of the first should be minimal. Taking high doses of medication can lead to the development of side effects such as hypotension, bradycardia and excessive drowsiness.
• Combine this drug with alcoholic beverages is not recommended. This is due to the fact that alcohol increases the concentration of the active substance of the drug in the blood, and this can lead to the development of undesirable effects.

Shelf life, storage and sale conditions

Tablets "Tizanidine" are released in pharmacies according to the medical prescription. Contain them preferably at room temperature in a dark place. It is necessary to protect the drug from small children.

The expiration date of the funds in question is 3 years. After this period, it is forbidden to take it.

Price, synonyms and analogues of the medicinal product

What is the difference between such drugs as Tizanidine, Tizanidine Ratiofarm and Tizanidine Teva? Instruction for the use of these products contains the same indications, side effects, contraindications, methods of taking and dosage. The only difference between these drugs is their manufacturers. Thus, all listed tools can be considered synonymous.

As for the analogues of the drug "Tizanidine", they can include such drugs as "Sirdalud", "Tizalud" and "Sirdalud MR".

How much are "Tizanidin", "Tizanidine Teva" and "Tizanidin Ratiofarm"? The instruction attached to these medicines does not answer the question posed. You can find out the price of these funds only in the pharmacy. As a rule, it is not very high and is about 120-170 Russian rubles (depends on the number of tablets in the package and the manufacturer).

It should be noted immediately that the drug "Tizanidine" has a relatively inexpensive cost (for example, such analogs as "Sirdalud", "Tizalud" and "Sirdalud MR" are a little more expensive, about 240-270 rubles). That is why most patients give their preference to the first drug.

Reviews about the drug

Now you know the purpose of such medicines as "Tizanidine", "Tizanidine Ratiofarm" and "Tizanidine Teva." Instructions for taking these drugs were presented above.

Patients who have ever used this medication, carry it in different ways. Most of the reviews allow us to conclude that the drug "Tizanidine" does not always justify the expectations of patients.

Many people note that taking this medication in one of three cases causes such side effects as severe spasms and muscle pain. Such reactions appear immediately after the use of the drug.

After using the second pill, some patients experience weakness, severe dizziness and the urge to vomit. With such symptoms experts recommend to stop taking the medication, otherwise their intensity may increase.

In some cases, after using Tizanidine, people had problems with pressure and stomach, as well as severe palpitations.

It should be noted that there are not that many positive reviews of the drug in question. Among them, one can single out the availability and cheapness of the medicinal product.

In connection with all of the above, it should be concluded that taking the medicine "Tizanidine", as well as its synonyms, is necessary only according to the indications and only according to the doctor's prescription.

In view of the large number of adverse reactions, experts strongly do not recommend the use of the drug during pregnancy and during breastfeeding, otherwise it can be detrimental to the health of the baby or fetus.