The preparation "Ceftriaxone" (the description to it contains such information) is highly effective against a significant number of gram-positive and gram-negative, anaerobic microorganisms. The medicine has a bactericidal effect. Activity of the drug "Ceftriaxone" (the doctors' reviews confirm this) is based on the ability to suppress the synthesis of elements of the cell membranes of pathogens. The drug is resistant to beta-lactamases, showing a hydrolytic effect. The drug is active against strains that have resistance (resistance) to other cephalosporins.
Medication "Ceftriaxone" is absorbed quickly enough after insertion into the muscle. During the day, a high concentration in the serum is maintained. The drug "Ceftriaxone" (experts' reviews confirm this) can penetrate all tissues and spinal fluid. About 60% of the drug is excreted in the urine in active form, about 40% - with bile.
The drug "Ceftriaxone" (reviews of experts confirm this information) is effective in infections of the urinary tract, the lower parts of the respiratory system. The indications include mild chancroid and primary syphilis, septicemia, pneumonia. The drug is prescribed with gonococcal infection, lesions of the abdominal cavity organs, joints, skin, soft tissues. The medicine "Ceftriaxone" (the doctors' reviews indicate this) is successfully used for bacterial meningitis and other serious infections. The drug is prescribed and as a prophylaxis of purulent-septic consequences after operations in patients with low immunity.
The medication is administered intravenously or intramuscularly. The drug "Ceftriaxone" in tablets is not available.
As a rule, patients from the age of twelve are prescribed 1-2 grams once a day. To treat severe infections caused by microorganisms that show moderate sensitivity to the drug, the use of four grams per day is allowed.
Dosage for newborns is set at twenty-fifty milligrams per kilogram of body weight per day. On the day the amount of the drug "Ceftriaxone" should not exceed 50 mg / kg. Patients under twelve years of age are prescribed (according to age) twenty to eighty milligrams per kilogram. For children weighing more than fifty kilograms, the dosage is set as for adults. Intravenous dose of fifty (and more) milligrams per kilogram is administered infusion for at least half an hour.
The duration of treatment will depend on the course of the disease. Use of the drug "Ceftriaxone" is recommended for another two to three days after the cessation of fever or after bacteriological laboratory confirmation of the elimination of the pathogen.
For infants and young children with bacterial meningitis, the initial dosage of the medication is one hundred milligrams per kilogram (but not more than four grams) per day. After determining the pathogen and establishing its sensitivity, the amount of the drug is reduced in accordance with the results.
The drug "Ceftriaxone" is not prescribed for hypersensitivity.
When using the drug, there are some side reactions. In particular, the medicine can provoke diarrhea, stomatitis, exanthema, vomiting, glossitis, puffiness. In a number of cases, an allergy, polymorphic erythema was observed. To adverse manifestations, experts also include pseudomembranous colitis, coagulation disorder, thrombocytopenia, granulocytopenia, kidney damage and other reactions. When injected into the muscle without a lidocaine solution, pain may occur.
Before using the drug should consult a doctor.