"Eufillin": reviews. "Eufillin": indications for use

What is the drug "Eufillin"? Comments on this medication, its indications, methods of application and side effects we will give in this article. You will learn about the form in which this drug is sold and what its price is.

General information

The drug "Eufillin", reviews about which are very diverse, is a bronchodilator drug. This medicine belongs to the group of xanthines. It can be purchased in almost any pharmacy, however, it is desirable to use such a drug for therapeutic purposes only as directed by a doctor.

Forms and composition of the drug

Currently, the drug can be purchased in two different forms, namely:

• In tablets that contain 150 mg of an active ingredient, such as aminophylline. In the sale of this drug comes in a cardboard package of 50, 10, 30 or 20 pieces.
• The drug "Eufillin" in ampoules. A 2.4% solution for injection (1 ml) contains 24 mg of aminophylline.

About what form of a medicine to apply for treatment of this or that disease, you should recommend only the attending physician.

Properties of the preparation

As mentioned above, the drug "Eufillin" in ampoules or tablets contains the main substance - aminophylline. In turn, this component is a mixture that consists of 80% theophylline and 20% ethylenediamine. This composition greatly facilitates the solubility of the drug, and also significantly improves its absorption.

The drug "Eufillin" from which is appointed by the doctors? The indications of this remedy are due to his influence on the bronchi. So, the drug "Eufillin" is able to relax the smooth muscle tissue of the body and eliminate the spasms that have arisen in them. It quite effectively improves the work of epithelial cilia of the respiratory tract, and also increases the reduction of intercostal, diaphragmatic and other muscle tissues.

What is the peculiarity of the drug "Eufillin"? The patients' reviews say that this medication is able to stimulate the respiratory center in the medulla oblongata, as well as improve pulmonary ventilation, oxygenate the blood and reduce the carbon dioxide content in it, that is, normalize respiratory functions.

Principle of action of a medicament

The mechanism of action of the drug is that it inhibits the phosphodiesterase enzyme, which causes the accumulation of cyclic adenosine monophosphate in the tissues, as well as the intake of calcium ions into the cells responsible for muscle contraction, which also relaxes the smooth musculature of the bronchi.

It should also be noted that the drug "Eufillin" (ampoules, tablets) is able to stimulate cardiac activity, due to increased frequency and strength of myocardial contraction. It lowers the tone of the blood vessels of organs such as the kidneys, brain and skin.

Providing a relaxing effect on the walls of veins in a small circle of blood circulation, this medicine helps reduce the pressure in it. The use of the drug "Eufillin" significantly improves the blood supply of the kidneys. Due to this, the formation and, accordingly, the excretion of urine considerably increases. The agent helps to slow the aggregation of platelets. One can not help saying that "Eufillin" makes red blood cells resistant to damage. In other words, it significantly improves the rheological properties of the blood.

It is also known about the tocolytic effect of this drug on the uterus. It is also capable of increasing the acidity of gastric juice.

Absorption and elimination

Medicinal product "Eufillin" - from what it is used by patients? Before answering the question posed, it should be said that this medication is absorbed fairly well from the digestive system. Its bioavailability reaches almost 100%, although with simultaneous intake with food, the absorption of the drug can be significantly slowed down.

This medication penetrates the milk of the nursing mother and does not stop before the placental barrier. Metabolism means solely in the liver. Its removal from the human body is through the kidneys.

Medication "Eufillin": indications for use

The drug "Eufillin" is prescribed for obstructive chronic bronchitis, for relieving asthma attacks (in patients with asthma of physical stress and as an additional remedy in other forms), with asthmatic status (only in combination therapy), heart failure, complex stroke treatment, and As well as other ischemic conditions of the brain, angina pectoris, Cheyne-Stokes respiration, pulmonary emphysema, pulmonary edema and other abnormalities that are associated with congestive events. According to the patients' reviews, the drug "Eufillin" (solution for intravenous injections and tablets) effectively lowers the pressure during the hypertensive crisis. It is often used to treat apnea of newborns, that is, in a condition characterized by periodic respiratory arrest (for 15 seconds), and is accompanied by abnormalities such as bradycardia and cyanosis.

Contraindications to use

The drug "Eufillin" (indications for the use of this drug include many exceptions) has a large number of contraindications.

So, the presented medication is highly not recommended for treatment if you have at least one of the following phenomena:

• Hypersensitivity to one of the constituent substances, including derivatives of an element such as xanthine (pentoxifylline, caffeine, theobromine);
• arterial hypertension;
• arrhythmia;
• Myocardial infarction;
• Pathology of the myocardium;
• heart failure;
• An ulcer of the duodenum or stomach;
• Chronic or acute (especially in the phase of exacerbation) gastritis;
• diarrhea;
• prostate adenoma;
• Pulmonary heart;
• Cystic fibrosis mastopathy;
• Hypoxemia;
• alcoholism;
• Hyperthyroidism;
• fever;
• Diseases of the rectum;
• Respiratory tract infections;
• Impaired liver function;
• Acute or chronic kidney failure;
• Edematous syndrome;
• breast-feeding;
• Hypernatremia;
• pregnancy.

Instructions for use

In the form of a solution, such a drug is administered intramuscularly or intravenously. It should be especially noted that the parenteral use of this drug is used only in urgent and emergency conditions. In this case, the dosage of the drug should be calculated individually and depend on the rate of excretion in different people, the severity of the patient's condition and the weight of his body.

What rules should be known to inject intravenously the drug "Eufillin"? A dropper with a drug should be placed very carefully, and most importantly - slowly.

According to the instruction, for adults in case of emergency situations, the dosage of this drug is selected at the rate of 6 mg per 1 kg of weight. To do this, the drug should be diluted in 20 ml of saline "Sodium Chloride" and inject the drug intravenously. The injection is very slow (for 5-8 minutes).

If the patient has an asthmatic status, then he is prescribed an infusion of 720 or 750 mg of medication. The duration of such therapy should not exceed 14 days.

To facilitate the patient's condition in obstructive lung diseases (especially in the acute phase), the administration of the drug begins with a dosage of 5 or 6 mg per 1 kg of the patient's weight. If necessary, it can be increased. However, this should be done very carefully, controlling the picture of the blood.

As for tablets, in this form, "Eufillin" is prescribed to 0.15 g after meals once or thrice a day. The course of admission may last several days or months.

In apnea of newborns, the initial dosage of this drug is 5 mg per 1 kg of weight per day (in 2 divided doses). In this case, the drug is administered via a nasogastric tube. After improvement, you should switch to maintenance therapy (2 mg per 1 kg per day in 2 divided doses). Duration of treatment of the disease can be several weeks or months.

To children of younger and older age the drug is prescribed depending on the indications and severity of the condition. The daily dosage varies between 6-15 mg per 1 kg of body weight.

Inhalation of "Eufillin"

The drug is indispensable in obstructive bronchitis. This is due to the fact that it facilitates the excretion of phlegm and extends the vessels of the bronchi well. In physiotherapy rooms, which are located in each clinic, inhalation procedures are carried out based on a large amount of this facility. Thus, 10 ampoules of "Dimedrol", as well as 500 ml of water, should be used for 3 ampoules of the drug. If a conventional compressor nebulizer is used for treatment , then this dosage will be much less, although the proportions should be preserved.

Before you dilute and use "Eufillin" for inhalation of a baby, you should always consult a pediatrician.

Possible side effects

According to reviews, the drug "Eufillin" can cause such undesirable phenomena as dizziness, insomnia, excessive excitement, persistent headaches, arrhythmia, limb tremors, lowering of blood pressure, abdominal pain, palpitation, nausea, heart pain, heartburn, allergic Reactions, vomiting, diarrhea, lowering blood glucose, increased sweating, changes in urine tests.

special instructions

In what cases should you take with extreme caution the drug "Eufillin"? The experts' testimonies testify that this drug should be used only according to the prescription of the doctor and strictly under his supervision, especially if the patient has a fever of unknown origin. With extreme caution, the drug should be taken for the elderly.

It should be noted that the drug "Eufillin" is able to raise the level of uric acid in the urine. During the use of this medication, special care should be taken when using a large number of foods and beverages containing caffeine.

Before parenteral administration, the drug solution should be heated to body temperature.

Drug Interactions

• With simultaneous use with this medication, the bronchodilating effect of Salbutamol and Terbutaline is markedly increased.
• Simultaneous reception of the drug "Eufillin", the price of which does not exceed 40 Russian rubles, with beta-blockers can easily cause bronchospasm.
• During the application of this drug, it should be borne in mind that its effect is markedly enhanced by simultaneous treatment with drugs such as "Erythromycin" and "Cimetidine", as well as an anti-influenza vaccine and oral contraceptives.
• The level of concentration of this drug in the blood drops with simultaneous use with drugs "Carbamazepine", "Rifampicin" and "Phenytoin."