Tablet "Silhouette": reviews of doctors, instructions for use. Birth control pills "Silhouette": reviews with endometriosis

In our era, a woman has the right to plan her pregnancy. This can be done in several ways, but one of the most convenient and effective is hormonal contraception.

The first means to prevent pregnancy in tablets contained a rather large portion of the active substance and inevitably led to side effects, such as weight gain. Modern hormonal contraceptives differ in that the dose of the active ingredient in them is negligible. This allows a woman to keep her weight under control. Moreover, oral contraceptives of the new generation can significantly improve the condition of the skin and hair, eliminate a small swelling during menstruation.

One of the modern means to prevent unwanted pregnancy is the tablet "Silhouette." Reviews about this tool can be found diverse. Let's take a closer look at the features of this drug.

If we consider this pharmaceutical product from the point of view of belonging to a clinical group, then it is a monophasic contraceptive with antiandrogenic properties intended for oral administration.

In what form is it produced?

Birth control pills "Silhouette", reviews about which in the main key are positive, have a white color, round biconvex form and engraving "G53" on one side. The blister contains 21 pieces.

Structure of the preparation

One tablet contains the following main active ingredients:

• Ethinylestradiol in an amount of 30 μg.
• Dienogest in a concentration of 2 μg.

Also in the composition there are also auxiliary components: lactose monohydrate, corn starch, hypromellose, talc, potassium polyarylate and magnesium stearate.

How does the drug work?

Tablet "Silhouette", reviews of which speak about its acceptability for young women, is a combined remedy with pronounced antiandrogenic effect. In its composition there are hormones ethinyl estradiol, which carries the function of estrogen and dienogest, which is a progestogen. This contraceptive performs the following functions in the woman's body:

• Inhibits ovulation.
• Increases the viscosity of cervical mucus.
• Changes the peristalsis of the fallopian tubes.
• Converts the structure of the endometrium.

The two main active ingredients in combination with each other have an effect of reducing androgens in the plasma.

For many women, the "Silhouette" tablet (the testimonial is a confirmation) helps to cope with the problem of mild to moderate acne, as well as with seborrhea.

The hormone dienogest is a derivative of norethisterone. It is less than 10 times more affinity to progesterone receptors than other synthetic substances of this group. The features of dienogest are that it does not have pronounced androgenic, glucocorticoid and mineralocorticoid properties. Independent use of this hormone at a dosage of 1 mg per day leads to a decrease in ovulation.

What is the pharmacokinetics of a contraceptive?

As it was said earlier, the tablet "Silhouette", the reviews of which speak of its popularity, has two active substances that behave differently in the human body.

Ethinyl estradiol when ingested into the small intestine is rapidly absorbed and reaches its maximum concentration after 1.5-4 hours. A significant proportion of the substance is metabolized by the liver. The absolute bioavailability of ethinylestradiol is 44%. This substance binds 98% to blood albumins, increases the concentration of globulin. This protein binds sex hormones. In the second half of the course of taking the drug, the maximum equilibrium content of ethinyl estradiol is noted.

This substance is metabolized in the intestinal mucosa and in the liver through aromatic hydroxylation with a large number of derivatives. The products of decay of the liver and kidneys are deduced in two stages:

• The first is 1 hour.
• The second period is 10-20 hours.

Ethinyl estradiol unchanged from the human body is not excreted.

Dienogest is also absorbed into the bloodstream through the wall of the small intestine and reaches its maximum concentration after 2.5 hours from the time of taking the contraceptive. Its bioavailability with ethinyl estradiol is 96%. Dienogest binds only to albumins. Its equilibrium maximum plasma concentration is achieved in 4 days of taking the drug.

Dienogest is metabolized by hydroxylation and glucuronization. The products of this disintegration are inactive and quickly leave the blood plasma.

Dienogest in small amounts in unchanged form is excreted by the kidneys. When consuming 0.1 mg / kg of the substance, about 86% are excreted in the first 6 days by the intestine and kidneys, and about 42% of the substance is removed in the first 24 hours with urine.

What dose should I take?

The pill "Silhouette", reviews about which are positive, should be taken every day and at a certain time. If necessary, you can drink a small amount of water. Be sure to follow the procedure indicated on the package.

The main guide to properly take the "Silhouette" (tablets) - the instruction. Feedback about this contraceptive testifies to the availability of the presentation of the method of its use in the attached annotation. It shows the scheme according to which one tablet of the drug is taken once a day for a period of 21 days. Then a seven-day break is done before starting a new package with the medicine. During this period, there is a "withdrawal bleeding". Usually this phenomenon begins 2-3 days after the last pill and is completed in 4-5 days. By this time, there is a need to take tablets from a new blister.

There is a very important nuance that characterizes the initial reception of the tablet "Silhouette." Instructions for use (the doctors' testimonials to confirm this) indicate the need for taking a contraceptive on the first day of menstruation. This condition is mandatory for those who previously did not use hormonal contraceptives or did not use these drugs for a month or more.

Features of contraceptive reception

If there was a transition from a combined oral contraceptive to a Silhouette tablet, an instruction manual, a doctor's recommendation recommends that the drug be taken at the usual time the next day after the last tablet was used.

If there was a need to switch from contraceptives containing only progesterone, then this can be done on any convenient day. If the patient removes the implant, for example, the IUD, then on the same day she can already take Silhouette. In case the woman took the contraceptive in the form of injections and decided to switch to the described tablets contraceptive, the first dose should be taken at the time when the planned injection should be made.

If a woman has a miscarriage on the 1st trimester of pregnancy, and she plans to take the Silhouette hormone pills, the instructions, testimonials and recommendations of doctors indicate the possibility of immediate use of this pharmaceutical product. If the abortion occurred at a later date, then there is a need to pause at 21-28 days and use condoms during this period.

What should I do if I missed taking the pill?

In the event that the delay in the reception does not exceed 12 hours, the strength of contraception does not decrease. The woman should use the pill as soon as possible, and the next drink at the usual time.

In the event that the delay formed a time interval greater than 12 hours, it is necessary to act according to the basic rules for taking the contraceptive:

• You can not interrupt the use of funds for more than a week.
• In order for the drug to work, you need at least 7 days of continuous reception.

Therefore, doctors give the following recommendations:

• If the pass in the reception occurred in the first week of use of the drug, then the woman should immediately drink a pill, and the next use at the usual time. At the same time, you need to use a condom in the next week.
• If this happened in the second seven-day period, then immediately taken a pill, and in barrier methods of contraception is not necessary.
• In the third week, the failure in taking the drug requires the algorithm described in the first paragraph. After that, proceed to the next blister without interruption. In this case, "bleeding cancellation" will not, however, there may be spotting.

You can also delay the onset of bleeding with a pill Silhouette. Comments of doctors on this manipulation are recommended in this case to continue taking the drug, replacing the blister with a new one. During the use of the second medicine package, a woman can mark her spotting uterine secretions.

Can an overdose occur?

The toxicity of the increased dose of hormones that make up the Silhouette tablets is low. In case of an overdose, nausea, vomiting, vaginal discharge or bleeding are noted. There is no need for therapy.

Can "Silhouette" be taken with other medicines?

It was noted that joint intake with drugs that activate microsomal enzymes, can lead to bleeding breakthrough and a decrease in contraceptive effect. Such drugs include Phenobarbital, Rafampicin, Hydantoin, Primidon, Carbamazepine, Rifabutin, Efavirenz, Nevirapine, Oxycarbazepine, Felbamate, Griseofulvin, Topiramate "," Ritonavir "and phytopreparation of St. John's wort perfumed.

The intake of certain antibiotics, such as tetracycline or ampicillin, in conjunction with Silhouette also reduces its effectiveness. In the case of combinations with any of the above drugs, there is a need for additional barrier protection for a period of 7 days, and with "Rifampicin" - in 28 days.

What are the side effects of the drug?

You can not decide on your own choosing this contraceptive. Remember that "Silhouette" - hormone tablets. The doctors' comments on the side effects of this contraceptive testify that it promotes the formation of thrombi in the arteries and veins. This phenomenon can be exacerbated by smoking, hypertension, violations of normal blood clotting, varicose veins, obesity, thrombosis and thrombophlebitis.

Among the frequent side effects are also noted:

• Migraine.
• Nausea and vomiting.
• Increased body weight;
• Painful sensations in the mammary glands and their enlargement;
• Emotional instability;
• Pain in the back;
• Cramps in the muscles of calves.

Many women refuse to use oral contraceptives because of fear of getting better. Are these fears justified? One of the important sources of information about whether it is possible to gain weight from the reception of "Silhouette" pills is reviews. The increase in body weight is noted for a fairly large proportion of women. That is why this effect of taking this contraceptive is the most common.

The following adverse events from the use of the preparation "Silhouette" differ in the lower frequency of manifestation in patients:

• Arterial hypotension or hypertension.
• Thrombophlebitis and varicose veins.
• Migraines and dizziness.
• Increased excitability.
• Stomach ache.
• Infectious diseases of the urinary system.
• Acne, exanthema, allergic and acneiform dermatitis, allopecia, erythema, pruritus, chloasma.
• Increased appetite or weight loss.
• Vaginal candidiasis, vaginitis.
• Fatigue, malaise, puffiness.
• Acyclic and painful bleeding, endometrial hyperplasia, endometritis, salpingitis.

There are also some other, but less frequent side effects from taking the "Silhouette" pill. Instructions for use, reviews of patients and doctors indicate the following undesirable manifestations:

• Anemia.
• Diseases of the cardiovascular system.
• Disorders of the blood circulation of the brain.
• Visual disorders.
• Sinusitis, bronchitis, asthma.
• Digestive disorders.
• Hypertrichosis, eczema, seborrhea, angioedema.
• Reduced appetite.
• Allergy.
• Scanty discharge, changes and tumors of the mammary glands, leiomyoma.
• Insomnia, depression.
• Arthralgia, myalgia.

There are also very rare side effects that can occur as a result of taking the drug Silhouette. Tablets, testimonials this confirm, with a frequency of less than 1 case of 10 000 are capable of provoking myocardial infarction, gallstones, cholecystitis and endometrial cancer.

Contraindications

The drug "Silhouette" can not be taken in the presence of some ailments. It:

• Diseases of veins and arteries, propensity to thrombosis.
• Pancreatitis.
• Porphyria.
• Jaundice or congenital syndromes of hyperbilirubinemia.
• Smoking after 35 years.
• Severe liver damage, including cancer.
• Vaginal bleeding of unexplored genesis.
• Migraine.
• Epilepsy.
• Anemia of sickle cells.
• Pregnancy and lactation.
• Lactase intolerance.
• Allergy to the components of the drug.

For any of these diseases, the contraceptive "Silhouette" is contraindicated.

Treatment of endometriosis

Endometriosis is a disease that is quite common in women. It is treated with conservative or surgical methods, depending on the circumstances of the ailment. "Silhouette" (pills) reviews in endometriosis deserved positive. This drug is often prescribed to patients, as an analogue of the contraceptive "Jeanine". Thus gynecologists mark its relative safety and good efficiency.

"Silhouette" leads to a gradual atrophy of the foci of endometriosis, regardless of where they are located. It reduces the synthesis of estrogens, inhibits ovulation and blocks the proliferation of cells of this tissue outside the uterine cavity. There is also a good anti-inflammatory effect from the use of the drug "Silhouette". Tablets reviews with endometriosis have positive - women note the disappearance of signs of dysmenorrhea, polymenorrhea and tenderness in sexual relations.

In addition, the active components of the drug "Silhouette" reduce blood supply to the foci of endometriosis. As a result, this tissue ceases to grow. The normal level of hemoglobin is restored.

It should be noted once again that the use of this drug should be recommended only by a doctor after a complete examination of the patient for the presence of diseases and previous states. Unauthorized use of hormonal contraceptives threatens with serious unwanted reactions of the body.