Efferalgan - instructions for use

"Efferalgan" is a popular antipyretic. And its composition varies slightly depending on the form of release. In the syrup for children - paracetamol, as well as auxiliary components: syrup, saccharin, polyethylene glycol, E202, flavors, citric acid, drinking water.

It is standardly produced in glass bottles of 0.09 l (additionally - a measuring spoon).

The "Efferalgan" composition (rectal suppositories): paracetamol, the auxiliary components are semi-synthetic acylglycerols.

Standard in the package 5 pieces, and in the pack there are 2 packages.

In the composition of effervescent tablets: paracetamol and auxiliary components: dry sodium carbonate, povidone, citric acid, saccharin, sorbitol, sodium docusate, baking soda, E211.

In the plates there are 4 tablets, and in the whole package - there are 4, there are 25 plates.

pharmachologic effect

"Efferalgan" instruction describes as a drug whose main active ingredient is paracetamol, which blocks cyclooxygenases-1 and 2, mainly in the central nervous system, while affecting the centers of heat regulation and pain. In inflamed tissues, the action of paracetamol on cyclooxygenase is blocked by specific, specific peroxidases. This explains the almost complete absence of anti-inflammatory action of the substance. Paracetamol does not affect the formation of prostaglandins in peripheral tissues, which explains its complete inability to influence the gastrointestinal mucosa and the electrolyte-water balance.

Candles "Efferalgan" instruction presents as a means of analgesic, non-expressed anti-inflammatory and antipyretic effect.

Paracetamol is usually absorbed completely and quickly. The maximum concentration of this substance in the serum occurs in 30-60 minutes. After use. Rapidly distributed on the tissues of the body, paracetamol weakly binds to plasma proteins (not more than 25%). It penetrates the blood-brain barrier.

The metabolism itself is produced in the liver. Paracetamol is excreted from the body in the form of metabolites. Output in the primary form of only 5% of the drug.

Indications

The drug "Efferalgan" is recommended for the following conditions and diseases:

- as an antipyretic drug at usual ORZ, infectious children's pathologies, a flu, post-vaccination complications, infectious-inflammatory diseases which are characterized by a hyperthermia;

- as an analgesic for moderate and mild pains (headache, pain in the striated muscles, toothache, peripheral nerve damage, pain in burns and injuries).

Contraindications

Contraindications to the reception of "Efferalgan" instruction indicates such (candles, syrup):

- serious violations of the processes of the liver or kidneys;

- increased susceptibility to the main component;

- Diseases of the blood;

- the age of up to one month (for syrup) and up to three months (for candles of 0.08 g);

- lack of enzyme G-6-FD;

Bleeding or inflammatory reactions in the rectum (candles).

Take this medicine with caution:

- with hepatic and renal insufficiency (namely, with family cholemia);

- In case of renal insufficiency, the minimum interval between the use of the drug in the syrup is 8 hours.

- Do not use candles for diarrhea.

Tablets "Efferalgan" instructions for use do not recommend taking when:

- increased susceptibility to components;

- regular (frequent) use of alcohol;

- pregnancy (1 and 3 trimesters) and during the period of feeding;

- lack of enzyme G-6-FD;

- at the age of up to fifteen years (body weight - less than 50 kg).

Tablets should be taken with caution:

- with violations of the liver and kidneys;

- with congenital jaundice (Dabin-Johnson syndrome, familial cholemia), viral hepatitis, age over 60 liters, liver disease (alcoholic).

Side effects

The side effects of taking Efferalgan are as follows:

- very rarely - vomiting, nausea, allergies (rash, urticaria, pruritus, Quincke's edema);

- false desires for deurination and defecation;

- inflammation of the mucous membranes of the rectum;

- extremely rare - thrombocytopenia, anemia, excess in the blood of methemoglobin, a deficiency in the blood of neutrophils, leukocytopenia.

With prolonged intake in overestimated amounts, a slight toxic effect on the liver and kidneys is possible.