Preparation "Celebrex": reviews, analogs, instructions for use, price

Defeat of the spine, acute pain in the joints and changes in connective tissue functions against the background of inflammation - unfortunately, these diseases have become the most common in our time. This state of things is influenced by the way of life, the lack of normal physical exertion, hereditary factors. In addition to the severe pain that people suffer in this condition, the patient's ability to destroy the entire body, changing the chemistry of the blood and affecting the normal operation of internal organs.

Therefore, it is so important to monitor your health and treat diseases in time. One of the effective drugs that belongs to the group of non-steroid drugs is called "Celebrex". The doctors' reviews confirm its effectiveness in comparison with a similar line of anti-inflammatory drugs.

The main effect of the drug

The advantage of the drug can be called its ability to suppress the activity of the inflammatory process at different stages of the disease. Getting into the blood, the drug is able to oppress COX2, which leads to the process of arresting inflammation. The medicine "Celebrex" has a pronounced analgesic property, antipyretic activity. Therefore, it not only eliminates inflammatory foci, but also removes even acute pain, reduces fever.

The merits of this drug include its minimal effect on platelets, that is, the drug does not cause problems with blood coagulability. When this non-steroidal agent is taken, irritation of the mucous membrane of the stomach and intestines does not occur, the risk of ulcers and gastritis in patients is reduced.

Therefore, "Celebrex" tablets are used much more widely than other NSAID preparations: "Naproxen", "Acetylsalicylic acid", "Ibuprofen".

Directed action

Capsules "Celebrex" have the ability to reduce severe pain in the joints, eliminate their stiffness, cope with excessive swelling. This effect allowed treating patients with a diagnosis of rheumatoid arthritis, osteoarthritis. The effect of the drug reaches its maximum effect within 24-48 hours after the first dose. With dysmenorrhea, the drug effectively removes pain, even the most acute. It is also effectively used to stop pain after surgery (maxillofacial and orthopedic surgery).

Patients with ankylosing spondylitis preparation "Celebrex" helps to avoid pathological processes and improves the functional capacity of the body. When observing the dynamics of familial adenomatous polyposis, the use of the drug led to a significant reduction in the growth of polyps in the thick and duodenal ulcers: their number and dimensions were reduced. Doctors say that adequate doses of medication and adherence to the treatment regimen make it possible to achieve an excellent result when using the drug Celebrex. Patients' feedback indicates minimal side effects when taking this medication.

Form and composition of the preparation

A highly selective inhibitor is a gelatin capsule of almost white or white color, they are not transparent and are marked as blue strips with the inscription: "7767" on one side and "100" or "200" on the opposite side. Contents of the capsule: granules of white color.

The composition of the drug includes: celecoxib (the main active ingredient), lactose, povidone K30, sodium lauryl sulfate, magnesium stearate, croscarmellose sodium. The casing is made of titanium dioxide and food gelatin. If it is advisable to administer the drug intramuscularly, "Celebrex" injections are prescribed. This type of drug is issued as a solution for injection of 2.2 ml in ampoules - the main substance celecoxib.

Pharmacokinetics

The drug is well absorbed into the blood when taken on an empty stomach and reaches its maximum values after about 2-3 hours. However, the use of the drug together with fatty foods can delay its accumulation for 1-2 hours. Therefore it is worth consulting with the doctor about the time of taking the medicine.

Getting into the bloodstream, the active substances do not bind to the red blood cells of the blood, but this mechanism does not affect the achievement of the desired concentration of the drug in the body. The drug is metabolized in the liver by oxidation and glucuronization with the participation of the enzyme CYP2C9. The drug is excreted in the urine and feces in the form of simple metabolites and only 3% of the active substance remains unchanged.

The preparation "Celebrex", whose analogues are similar in composition, is recognized as a means of causing minimal harm to health, thanks to the ability to absorb as much as possible and is almost completely eliminated from the body. At a low body weight, a higher concentration of the drug in the blood is observed, and this phenomenon is observed more in women. It is not known why, but the people of the Negroid race have the same dynamics. Therefore, these groups of patients are prescribed lower doses of the drug at the beginning of therapy.

Indications for use

As a non-steroidal anti-inflammatory drug for symptomatic treatment, the drug Celebrex is prescribed. Indications for use:

• rheumatoid arthritis;
• osteoarthritis;
• Spondylitis;
• Algodismenorea;
• Acute pain (postoperative period, back pain, musculoskeletal diseases);
• Are used in the complex treatment of adenomatous polyposis.

It is worth noting that an adequate treatment can be prescribed only by the attending physician on the basis of the conducted studies.

Methods of taking the drug

Take medication is necessary inside, regardless of food intake. Do not chew the tablets, drink with plain water. It is worth noting that with prolonged use of the drug may cause cardiovascular complications. Therefore, doctors prescribe a short course of treatment with the drug "Celebrex". Experts' reviews confirm that the maximum dose for long-term treatment should not exceed 400 mg per day!

• Treatment of osteoarthritis - an adequate dose is 200 mg per day. One-time reception is possible or split into two (at the same time intervals).
• Rheumatoid arthritis - a dose of 100 or 200 mg is suggested to 2 times a day. At especially serious displays - up to 400 mg, twice a day.
• Ankylosing spondylitis - 200 mg per day, for 1 or 2 admission. At the discretion of the doctor, the dose may be increased to adequately safe
• Dysmenorrhea and severe pain syndrome - the therapy begins with 400 mg per day and, if necessary, another 200 mg is added on the first day of therapy. In the following days it is necessary to take 200 mg twice a day.

The duration of treatment is determined by the attending physician.

Contraindications to the use of the drug

In addition to possible allergic reactions to the components of the drug, there are restrictions in which it is forbidden to use the drug Celebrex:

1. Asthma is bronchial, hives, allergies to other NSAIDs.
2. Postoperative period after aorticoronary shunting.
3. Peptic ulcer (exacerbation).
4. Bleeding of the gastrointestinal tract.
5. Inflammation of the intestine.
6. Heart failure.
7. Severe hepatic insufficiency.
8. Renal insufficiency.
9. Pregnancy and lactation.
10. It is not recommended to apply to 18 years.
11. Hypersensitivity to the components of the drug and sulfonamides.

With caution should be used drug with fluid retention in the body, diseases of the cardiovascular system, diabetes.

Adverse events

Despite the high effectiveness of the drug, with long-term admission or non-compliance with the regimen and dosage, side effects from the use of Celebrex may occur. Patients' testimonials indicate the most common symptoms, such as:

• Allergic manifestations: rash, hives, itching.
• Flatulence, the phenomena of dyspepsia, swelling, insomnia.
• Cough, rhinitis, influenza-like reactions and respiratory tract infections.
• Urinary tract infections.

Much more rarely observed increased anxiety, anemia, tinnitus, hot flashes, arrhythmia, hypertension arterial. Some patients reported the formation of ulcers in the digestive tract, angioedema edema, the formation of bullae on the skin, exacerbation of pancreatitis or its development, confusion. All these symptoms can occur only with a short course of treatment (up to 12 weeks, at a dose not exceeding 800 mg). But in the case of prolonged therapy (up to 3 years) there are:

• Frequent: stool disorder, hypertension, ear infections, angina pectoris, myocardial infarction, nausea, dysphagia, prostatitis, increased creatinine.
• Rarer: arrhythmia, angina pectoris, ischemic stroke, atherosclerosis, sleep disorder, vaginal bleeding, oral ulcers, dysmenorrhea, increased hemoglobin, lowering of hematocrit.

Interaction of the drug with other drugs

The drug is actively biotransformed with the participation of P450 2C9 (cytochrome). Therefore, direct interaction of the drug with other agents is possible:

1. The simultaneous use of the drug Warfarin increases the risk of fatal bleeding.
2. The preparation "Ketanazol" and "Fluconazole" increase the concentration of active substance celecoxib almost twice.
3. Taking ACE inhibitors or angiotensin blockers with NSAIDs can significantly reduce their antihypertensive effect
4. The combination of drugs that contain lithium can significantly increase its level in the blood.
5. It is forbidden to simultaneously use the preparation "Celebrex", analogs containing celecoxib, with other NSAIDs!

Drug analogues

It is worth noting that the preparation "Celebrex" is not too much, its price is on average from 400 to 450 rubles. For 10 capsules (a dosage of 100 mg). However, with prolonged therapy, such treatment is rather expensive for the patient. In this case, with the consent of the doctor, prescribe celecoxib-containing agents. Analogues for the preparation "Celebrex" are the following:

• The drug "Ranselak";
• Medicament "Revmoxib";
• "Flogoxib" tablets;
• Capsules "arthoxy".

These analogues contain the same active substance and have an almost identical therapeutic effect in the treatment of diseases. Note that an adequate dose of an analogue is also prescribed only by the attending physician. In this case, the doctor takes into account the different composition of the auxiliary agents in analogues, they contain different additives as compared with the preparation "Celebrex". Instruction, doctors' reviews testify to the possibility of an allergic reaction from the patient to the auxiliary substances of different medicines of the same group.