Nitrofurantoin: instructions for use, price

What is a substance like nitrofurantoin? The instructions for using this element will be presented below.

Chemical properties

What properties are characteristic of a compound such as nitrofurantoin? The instruction for use asserts that this is a nitrofuran derivative. It exhibits pronounced antimicrobial properties. Most often, drugs with such a component are used to treat infections in the genitourinary sphere.

Physical properties and shape

What is nitrofurantoin? Instructions for use asserts that this is a crystalline powder of orange or yellow color, which has a specific bitter taste. This compound is very poorly soluble not only in water, but also in alcohol.

In what forms are drugs released with a component such as nitrofurantoin? The reviews report that such products are manufactured in the form of tablets of varying dosage. They can be covered with an enteric coating or be released without it.

Pharmacodynamics

Nitrofurantoin (the price of the drug with this substance is indicated below) shows bactericidal and antibacterial properties. This substance inhibits the synthesis of proteins, ribonucleic and deoxyribonucleic acids, and also reduces the permeability of cell membranes and the rate of metabolism (aerobic) of harmful bacteria.

Pharmacokinetics

What kinetic properties are characteristic of a component such as nitrofurantoin? Instructions for use say that this substance has a very high absorption capacity. Its bioavailability is about 50%. And the use of food increases this figure.

According to experts, the smaller the crystals of the chemical compound, the better they dissolve and enter the blood.

About 60% of the component under consideration binds to plasma proteins. Its metabolism is carried out in the liver tissues, and the elimination half-life is about 25 minutes.

Indications

Preparations with the substance are prescribed in the following cases:

• Prevention of cystoscopy, catheterization and other urological operations and research.
• Treatment of infections in the genitourinary sphere (for example, with cystitis, pyelitis, pyelonephritis, urethritis).

Prohibitions for admission

Nitrofurantoin is contraindicated to use:

• With oliguria;
• Expressed violations in the work of the kidneys;
• Pregnancy;
• Chronic heart or kidney failure;
• Lack of glucose-6-phosphate dehydrogenase;
• Allergies to the substance;
• Up to one month of life;
• Chronic hepatitis or cirrhosis;
• Acute porphyria;
• Lactation.

Particular care should be taken in patients with bronchial asthma, as well as in the presence of fibrotic changes in the lungs.

Nitrofurantoin: instructions for use

The price of drugs with such an active substance is not very high. If they were released in the form of tablets, they are prescribed inside, with plenty of liquid. Typically, such drugs are prescribed to patients in a dosage of 50-150 mg to four times a day. The course of treatment with this drug should last 5-7 days.

The maximum single dose of the drug for an adult is 0.3 g. A day can be consumed up to 0.6 mg of the drug.

To children, this medication is prescribed for 5-8 mg per kilogram of weight. The daily dosage of the drug is divided into 4 divided doses.

If required, the treatment with this remedy can be extended to 10 days. However, this requires a control of the sterility of urine.

Occasional phenomena

After taking nitrofurantoin, the patient may experience:

• Diarrhea, hepatitis, cholestatic syndrome, pancreatitis, pseudomembranous enterocolitis;
• Vomiting, nausea, dizziness, headaches;
• Asthenia, arthralgia, nystagmus, myalgia, anaphylactic shock;
• Eosinophilia, lupus-like syndrome, rashes on the skin, chills;
• Cough, fever, drowsiness, bronchoobstructive syndrome, pain in the chest, interstitial changes in the lungs;
• Abdominal pain, peripheral neuropathy.

With prolonged use of the drug, the risk of developing a malignant tumor in the kidneys increases.

Special Recommendations

People with impaired electrolyte balance, anemia, kidney disease, and a deficiency of B vitamins have a high probability of developing peripheral neuropathy.

This substance is ineffective in the treatment of prostatitis, diseases of the cortical substance of the kidneys and purulent parainfrit.

This tool is not recommended to combine with drugs that have a bad effect on the kidneys.

Cost and Feedback

How much are drugs with such a substance as nitrofurantoin? The price of the most popular means - "Furadonin" - is about 120 rubles.

According to the patients' reviews, the component under consideration is well manifested in cystitis. However, it should be noted that taking drugs with nitrofurantoin quite often causes headaches, abdominal pain, vomiting and nausea.