The agent "Simvastatin" instructions for use characterizes as a hypolipidemic drug, which is part of the statin group and is an inhibitor of reductase type HMG-CoA. This drug is a prodrug, because in its structure there is a closed, so-called lactone ring, which after being ingested into the human body is hydrolyzed. The use of the drug "Simvastatin" (instruction for use on this emphasizes special attention) helps to lower the blood levels of triglycerides and lipoproteins, as well as total cholesterol. At the same time, the therapeutic effect begins to appear, approximately 12 to 14 days after the start of use, and the maximum result is achieved by the fourth to sixth week.
This drug is produced mainly in the form of biconvex round tablets. The composition of each dragee as the main active ingredient is twenty milligrams of simvastatin. Additional components are milk sugar, polyvinylpyrrolidone, calcium stearate, citric acid, hypromellose, microcrystalline cellulose, butyl hydroxy anisole, ascorbic acid, corn starch, titanium dioxide, talc and macrogol 4000.
To prescribe the hypolipidemic drug "Simvastatin" the instruction for use advises, for example, for the therapy of people suffering from primary hypercholesterolemia. However, use this tool in this case should only be in case of ineffectiveness of diet therapy. For treatment of combined hypercholesterolemia, the preparation "Simvastatin" is also excellent. Indications for prescribing include a disease such as hypertriglyceridemia.
Take these tablets is strictly forbidden to people suffering from acute forms of violations in the liver, as well as severe kidney failure. In case of individual intolerance to simvastatin or any of the auxiliary components, experts recommend to refrain from taking the hypolipidemic drug "Simvastatin". The instructions for use do not permit prescribing this medication to patients who are under the age of eighteen, pregnant women, and young mothers who breastfeed. With great caution should use these pills patients with liver disease, arterial hypotension or epilepsy. With chronic alcoholism and serious kidney disease, the medicine "Simvastatin" should be taken only under the supervision of a doctor. In addition, the list of relative contraindications includes increased and decreased tone of skeletal muscles.
As for the possible side effects that can be provoked by the use of the drug "Simvastatin", first of all, here we should highlight the risk of developing pancreatitis, peripheral neuropathy, arterial hypotension, myopathy, lupus-like syndrome, rhabdomyolysis and thrombocytopenia. In addition, convulsions, dizziness, flatulence, loss of appetite, angioedema, skin rash, hyperemia, urticaria, eosinophilia, photosensitivity, vasculitis, fever, muscle paresthesia, anemia and alopecia can occur.