Instructions for use of "Azimed", reviews about the drug

Many people try to avoid antibiotic treatment because of side effects of this group of drugs. However, there are drugs that can be called relatively safe - these are macrolides. They have a minimum of negative impact on the body and at the same time are able to quickly eliminate pathogenic pathogens. "Azimed" is one of the representatives of such antibiotics. All the necessary information about the admission and features of treatment with medication contains instructions for use. "Azimed" is available in several forms, which makes it possible to use it for the treatment of patients of all age groups.

General description of the tool

The class of antibiotic-macrolides was replenished with "Azimed". It is a modern bactericidal drug, produced by several pharmaceutical companies - Kyivmedpreparat and Arterium (Ukraine). Compared with erythromycin, the drug is more stable in the acidic environment of the digestive tract, which provides it with higher bioavailability and significantly reduces the risk of side effects.

"Azimed" penetrates deeply into tissues and organs, where it begins to accumulate. This effect creates a high lipophilicity of the drug. High concentration of the drug in the focus of the disease persists for 36-50 hours. This allows you to reduce the daily dose and the frequency of medication, which is also a significant advantage. The antibiotic has a wide range of effects, as described in the instructions for use. "Azimed" passed the necessary clinical studies, during which the effectiveness and safety of the drug was proved.

What is included in the composition?

Antimicrobial action of the drug provides the main active substance - azithromycin. This is azalide having a 15-membered lactone ring with an additional nitrogen atom in the nucleus. The chemical composition and structure of the molecule secrete azithromycin among other representatives of macrolides. The substance shows great activity with respect to Gram-negative pathogens: the E. coli (Afanasieva-Pfeiffer), moraxella catarrhis, chlamydia trachomatis, mycoplasma pneumonia.

Sensitivity to azithromycin is manifested by causative agents of pertussis and diphtheria, Helicobacter pylori, ureplasma, spirochetes, anaerobes, listeria. Organisms resistant to erythromycin are absolutely not sensitive to Azimed.

Additional components, which are part of the chemical composition of the drug, enhance the therapeutic effect. These include calcium anhydrous hydrogen phosphate, magnesium stearate, corn starch, microcrystalline cellulose, titanium dioxide, lactose, macrogol, triacetin, hypromelose, sodium lauryl sulfate.

Types of Macrolides

Modern antibiotics-macrolides are divided into natural and semi-synthetic. The first group includes erythromycin, leucomycin, oleandomycin, josamycin, spiramycin. They are obtained from certain microorganisms. Natural macrolides are characterized by high efficiency, but pathogenic agents quickly develop resistance to them.

Semisynthetic macrolides are a newer group of antibacterial agents. They have a wide range of effects, high antimicrobial activity, are well tolerated by the body. The therapeutic effect of such drugs persists for a long time. This type includes azithromycin, clarithromycin, rookytamycin, flurithromycin, roxithromycin. A distinctive feature is the possibility of influencing gram-negative bacteria.

Mechanism of action

Macrolide "Azimed" has an antimicrobial effect due to the influence on the ribosomes of cells of microbes and disrupting protein synthesis. Infectious agents can not withstand such an attack and are destroyed. A distinctive feature is a moderate anti-inflammatory and immunomodulatory effect, which has an antibiotic. Unlike other antibiotics, Azimed can stay active for several days.

Forms of release

The preparation is available in the form of capsules (250 mg), tablets (500 mg) and powder for suspension (250 mg of active ingredient). The tablet form is intended for the treatment of adults and children weighing not less than 25 kg. The powder prepared from the powder has a pleasant fruity aroma. The volume of the bottle is 20 or 30 ml. In the kit there is a measuring spoon and a syringe.

Indication for appointment

Macrolide antibiotic "Azimed" is used to treat a variety of pathological conditions of infectious etiology. The drug is most often prescribed to patients with intolerance to cephalosporins and penicillins. In the presence of a disease caused by microorganisms susceptible to azithromycin, a specialist will calculate an individual therapy regimen for this medication.

Indications for the appointment of "Azimed" are the following ailments:

• Infection of ENT organs (otitis media, tonsillitis, pharyngitis, sinusitis, sinusitis);
• Infection of the lower respiratory tract (extrahospital pneumonia, bronchitis, exacerbation of chronic diseases);
• Diphtheria, pertussis;
• Sexually transmitted diseases (gonorrhea, chlamydia, chancroid, syphilis)
• Urethritis, cervicitis;
• Pathology of the oral cavity (periodontitis, periostitis);
• Infectious processes of soft tissues and skin (impetigo, chronic migratory erythema, secondary pyodermatosis, beshiha, severe acne);
• Peptic ulcer of the stomach or duodenum, caused Helicobacter pylori.

The drug may be prescribed as a prophylaxis for whooping cough after contact with an infected person. Antibiotics are used to sanitize the carriers of meningococcal infection. Azithromycin is used in dentistry to prevent the development of endocarditis.

Does "Azimed" designate children?

In pediatric practice, cases of respiratory infections of infectious etiology are most common. In infants, such ailments can provoke the development of serious complications. To avoid undesirable consequences, doctors prescribe antibacterial therapy. Most specialists prefer to use macrolides for treatment, for example, "Azimed" (suspension or tablets).

The drug has proven effective against both extracellular and intracellular pathogens. It is prescribed as starting therapy even for complex diseases of bacterial etiology. This is the safest antibacterial drug that practically does not cause side effects and is well tolerated by the body. Usually, experts prescribe to children a minimum dose of the drug "Azimed" (100). For children this concentration of the active substance is considered safe. This means that in 5 ml of the finished suspension contains 100 mg of azithromycin.

How to prepare a suspension?

It is important to follow the rules for the use of the drug. This directly affects its therapeutic effectiveness. How to grow Azimed to get a suspension? In the vial is a powder from which to prepare the drug. To do this, measure with a syringe 11 ml of cooled boiled water and add it to the bottle with the drug. After this, the resulting mixture should be shaken thoroughly until a homogeneous mass is obtained. As a result, 25 ml of the suspension should be obtained.

The finished product is stored only for 5 days, after which it is strictly forbidden to use it. Before each intake, the vial should be shaken. Measure the required amount of medication with a syringe or spoon. After taking Azimed, you should drink a small amount of liquid (tea, juice) to clean the mouth of the suspension residues. Syringe or spoon after use should be washed with running water and dried.

Dosage

The necessary dosage of the drug is calculated by the doctor individually. According to the instructions, with infectious pathologies of the upper and lower respiratory tract, it is recommended to give 10 mg of active ingredient per kilogram of the patient's weight. That is, for example, a child weighing 5 kg, you need to give 2.5 ml of suspension.

In the form of tablets (250 mg), the drug is indicated for children weighing more than 25 kg. Some experts recommend giving the drug in the form of a suspension if the weight of the child is less than 45 kg. In this case, you can buy powder for the preparation of an oral suspension of Azimed 200 mg (volume 30 ml). At weight of the child more than 45 kg the adult dosage is appointed. The scheme of treatment is selected at the discretion of a specialist.

Multiplicity of administration and daily dosage will depend on the diagnosis and the presence of concomitant diseases. Adult patients are usually prescribed "Azimed" 500 mg. This dosage is usually taken once a day. However, in pathologies that are sexually transmitted, chronic migratory erythema and ulcer caused by Helicobacter pylori, it is shown that 1 g of azithromycin is taken per dose per day.

When should I refrain from taking medication?

Contraindicated drug in case of intolerance, hypersensitivity to macrolides or components in the composition. Taking medication can cause serious complications. Also "Azimed" in the form of tablets is not prescribed for children weighing less than 25 kg, and for women during pregnancy.

The active ingredient is metabolized in the liver and is excreted from the body along with bile. Therefore, patients who have a history of serious impairment of liver function, it is not recommended to use an antibiotic based on azithromycin. In the presence of mild renal dysfunction, the dosage of the medication should not be changed, but the treatment of such patients should be under the supervision of specialists. Precautions are prescribed for elderly patients.

What side effects can Azimed cause?

The antibiotic in most cases is well tolerated. The reason lies in the fact that macrolides are non-toxic and the most safe among antimicrobial medicines. This is confirmed by the patients' feedback, and instructions for use. "Azimed" only in rare cases provokes the development of undesirable phenomena, which are most often expressed from the digestive tract. Diarrhea, nausea, vomiting, flatulence, abdominal pain are one of the most common signs of the negative effects of the drug on the body.

With prolonged use of an antibacterial agent, an allergic reaction may develop in the form of rashes on the skin, hives, itching. More serious consequences - Stevens-Johnson syndrome, toxic epidermal necrolysis - are extremely rare.

On the part of the hearing organs, side effects (ringing or tinnitus, deterioration of hearing) are reversible and occur rarely. The central nervous system can also react negatively to antibiotic therapy. This is expressed in such symptoms as dizziness, taste distortion, cramps, drowsiness, asthenia, insomnia.

Side effects also include cholestatic jaundice, necrotizing hepatitis, anaphylactic shock, arterial hypertension, aggressiveness, nervousness, thrombocytopenia. Suspension or Azimed tablets are discontinued when side effects develop.

Application Features

Antibiotic should be correctly combined with the use of other medications that can affect its bioavailability and effectiveness. Simultaneous reception of antacids will slow down the process of absorption of the drug, which warns patients instructions for use. "Azimed" should be taken no less than two hours after the antacid.

Macrolide is able to increase the concentration in the blood serum of indirect anticoagulants, valproic acid, cyclosporine, theophylline, ergot preparations. An antibiotic may increase the bioavailability of digoxin when administered orally.

To avoid undesirable consequences of antibiotic treatment, it is necessary to follow the recommendations of the doctor clearly, follow the dosage regimen, do not increase the dosage. It is important not to miss the time of taking the medication. In large dosages, "Azimed" (500 mg) can be used only for the treatment of adults.

Antibacterial drug is recommended to take an hour before meals or two hours after eating. Tablets are washed down with a lot of water, as well as a suspension. The child is allowed to drink the medicine (suspension) with juice or tea. In this form, "Azimed" store no more than 5 days in the refrigerator. After taking the last dose, you should get rid of the remainder of the suspension.

How to replace "Azimed"?

The price of the medicine is slightly higher than the cost of other antibacterial agents. The drug in the form of tablets and a dosage of 500 mg will cost the patient 160-200 rubles. The cost of the suspension is 140-170 rubles (dosage 100 mg / ml). However, the drug can not always be found in pharmacies and patients try to find a substitute for it. It should immediately be taken into account that it is better not to count on the help of a pharmacist in such a question. Prescribe antibiotics can only a doctor, given the patient's condition, age and the presence of concomitant diseases. Only after consulting a specialist you can replace "Azimed".

Analogues based on azithromycin, the original tool has the following:

1. "Ormax".
2. "Sumamed".
3. Zitroleks.
4. "Azivok".
5. "Asit".
6. "Hemomycin".
7. "Azithromycin".
8. "Ziomycin".
9. "Azitro".
10. "Azitral".
11. "Zomax".

Each of the medicines has its own indications and application features. The optimal antimicrobial preparation for the treatment of an infectious disease can be prescribed only by the attending physician. It is recommended to pre-pass laboratory tests to confirm the presence of a bacterial pathogen and determine its sensitivity to the drug "Azimed". The price of substitutes will depend on the dosage of the active substance and the manufacturer.

"Sumamed" or "Azimed"?

"Sumamed" is another antibiotic-azalide from the group of macrolides. In small concentrations, it has a pronounced bacteriostatic effect. It breaks the synthesis of protein in the cells of microbes, which provokes changes in the processes of metabolism, prevents reproduction. Currently, this antibacterial drug is often prescribed in pediatric practice. "Sumamed" is also suitable for the treatment of more adult patients.

Sumamed is produced by the Croatian pharmaceutical company, which affects not only the quality, but also the cost of the drug. The drug can be purchased in the form of tablets (125 and 500 mg), gelatin capsules (250 mg) and powder for oral suspension (100 and 200 mg). The analogue of "Azimed" also has immunomodulating properties unrelated to its antibacterial effect. Experts argue that this ability of the drug is due to the impact on cyclooxygenase and the formation of superoxide ions of oxygen.

Both antibacterial drugs have minimal negative impact on the intestinal microflora. This allows you to avoid unpleasant consequences from the gastrointestinal tract. With proper administration of the drug will not provoke the development of dysbiosis.

"Sumamed" can be used to treat the youngest patients. Good tolerability and minimal side effects made this tool particularly popular.

Patient Reviews

Treatment of many serious diseases can not be imagined without antibacterial drugs. Only by these means can the viability of pathogens be suppressed. One of the representatives of the last generation of safe antibiotic-macrolides is "Azimed".

The feedback from patients and doctors suggests that this is an effective medicine that exerts an immediate therapeutic effect and that does not cause any side effects from the internal organs and systems. Use the tablet or suspension should only be recommended by a specialist who will calculate the necessary dosage of the active ingredient and the duration of treatment. After treatment with an antimicrobial agent, many patients still recommend that they undergo restorative therapy and improve the intestinal microflora.