The drug "Gentamicin" - instruction

The instructions for use give for the preparation ointment "Gentamycin" the definition is this: this drug is a typical representative of antibiotics of the group of aminoglycosides with a wide spectrum of action.

The drug is available in tubes and cans of fifteen grams with a concentration of active substance in one tenth of a percent.

The drug "Gentamicin" instruction: pharmacological properties

The action it performs is bactericidal. It is active against gram-negative bacteria-aerobes, Gram-positive cocci aerobes, are unreceptive to it anaerobic bacteria, as well as niserell and some of the strains of streptococcus.

The medicine "Gentamicin" (ointment). Instructions for use: pharmacokinetics

After intramuscular injection, the active substance is rapidly absorbed and reaches its maximum concentration in the blood in half an hour-hour. With plasma proteins, only up to ten percent of the drug binds. It is evenly distributed in all tissues of the body, is not metabolized, is able to penetrate the placental barrier. The half-life of the drug ranges from two to four hours, up to ninety-five percent of the substance is excreted in the urine, the rest with bile.

The drug "Gentamicin". Instruction: How to use

For external use it is used three to four times a day. The maximum permissible daily intake, for adults, as for children, is described only with intramuscular and intravenous administration and is up to five milligrams per kilogram of body weight.

Ointment "Gentamicin". Instruction: interaction with other medicinal substances

In the case of simultaneous use with vancomycin, aminoglycosides, cephalosporins, ethacrine acid, it is likely that toxic effects on the hearing and kidneys will increase. And the application together with indomethacin, furosemide, etakrinova acid leads to an increase in the concentration of gentamicin in the blood and increase its toxic effect on the body. If applied simultaneously with opioid analgesics and substances that are used to achieve inhalation anesthesia, then the risk of neuromuscular blockade increases, up to the occurrence of apnea.

"Gentamicin" instruction: application in lactation and pregnancy

This drug is absolutely contraindicated in pregnancy. If there was a need for its use in the lactation period, breastfeeding should be stopped immediately.

Side effects of ointment "Gentamicin" instructions for its use describes the following:

• From the gastrointestinal tract may develop vomiting, nausea, hyperbilirubinemia, the activity of hepatic transaminases may increase.
• From the hematopoietic organs may develop anemia, granulocytopenia, leukopenia, thrombocytopenia.
• The urinary system can also suffer through the development of proteinuria, oliguria, renal insufficiency and microhematuria.
• CNS and peripheral nervous system can give headache, hearing loss, vestibular apparatus disorders, irreversible deafness, disorders of neuromuscular conduction, drowsiness.
• There are also sometimes allergic reactions, such as itching, skin rashes, fever, urticaria and the rarest of them - Quincke's edema.

Indications for the use of ointment "Gentamicin"

For external use against infectious inflammatory pathologies that are caused by microorganisms sensitive to the drug, such as superficial folliculitis, pyoderma (even gangrenous), sycosis, furunculosis, seborrhoeic infected dermatitis, paronychia, acne infected, varicose infected ulcers, secondary bacterial infections in viral And fungal lesions of the skin, infected skin wounds of various etiologies (wounds, burns, ulcers that are difficult to heal, insect bites).