IGH-study - this is what?

Oncological diseases are the most terrible reality for the vast majority of people. But in order to identify a serious problem in time and start to effectively get rid of it, it is necessary to conduct special surveys. исследование. One of them is the IHC study.

Genes, receptors and growth factors

The exact causes that cause cells to actively share, forming neoplasms, often having an oncological orientation, are still unknown to science. But here is how the growth of cells is already well enough studied. Cells of tissues have a complex structure. -рецепторы. On the cell surface there are so-called HE R-2 receptors. They serve as a kind of antenna, listening to the commands of the body. берет начало от английского словосочетания human epidermal growth factor receptor 2 , что в дословном переводе значит "рецептор человеческого эпидермального фактора роста". By the way, the abbreviation HE R-2 originates from the English word combination " human epidermal growth factor receptor 2" , which in literal translation means "human epidermal growth factor receptor". These and that receptors make the cell divide, grow or self-repair.

Active receptor activity and tumor

Unfortunately, not always the human body works as it should be ideally, without failures and illnesses. -рецепторы начинают активно получать команды "делиться и размножаться". While science does not know exactly why, but it happens that HE R-2 receptors begin to actively receive the "share and multiply" commands. And since these cellular elements are very executive, they force the cells to actively divide, forming a tumor. Only medical examinations, including IHH- investigation, allow to determine the status of neoplasm, as well as the prognosis for the treatment and life of the patient.

Gene status of tumor

Oncological formations of modern medicine are determined by the status of hormonal therapy. This status can be negative (negative) and positive (positive). Ihcho- study helps to specify the nature of the neoplasm . What does immunohistochemistry show? This study helps to establish the hormonal dependence of the neoplasm - herceptal status, and therefore, to choose the right treatment method to get an effective result.

Negative and positive

The fact that the hormonal herceptor-tumor status bears the name "positive" or "negative", will tell a lot to the competent doctor. But in and of itself these definitions do not refer to emotions, as a simple philistine who first heard about the ICG study might think. The revealed positive hercept status indicates that this type of cancer is more aggressive, it develops faster, spreading through the body through metastasis. But at the same time, such a malignant tumor with a high level of probability will respond to certain types of medications. Negative herceptus-neoplasm status will tell that the tumor develops slowly, but there is not adequate medication for it yet.

Immunohistochemistry - what is it?

One of the most common oncological diseases among women is breast cancer. IGH-study helps to determine the type of neoplasm and choose the treatment in accordance with the current situation. Immunohistochemistry is a laboratory study of a biopsy specimen (biomaterial taken in the process of biopsy) with the help of a special coloring substance. -рецепторы, и чем больше рецепторов, влияющих на появление и развитие "ненормальной" клетки, тем ярче будет окраска исследуемого биоматериала. This substance stains HE R-2 receptors, and the more receptors that influence the appearance and development of the "abnormal" cell, the brighter the color of the biomaterial being studied.

How is the neoplasm status determined?

The colored biomaterial undergoes a visual examination during the laboratory test for determining the hercept status. For this purpose, a special scale is applied, which has a gradient color from 0 to 3+. This method allows us to distinguish 4 main thresholds, depending on which it is supposed to lead the patient further. It seems - which is easier? Dye the test tissues with a special substance, place under a microscope, carefully examine, comparing the seen with the control color samples, and establish the herceptor-tumor status. But here a huge role is played by the human factor, the features of lighting and so on.

How is the IHC study conducted

If a suspected cancer is diagnosed, the breast is examined. The interpretation of the immunohistochemical examination contains only four thresholds. But the problem is that the average two values, and this will be 1+ and 2+ on the scale, suggest an unclear result that requires additional investigation by another method. That is, IHH- study is the most ambiguous method of revealing the hercept-status of a neoplasm. In addition, the human factor and external circumstances actively influence the result of the research, as already mentioned. The only thing that most accurately determines the two extreme outcomes - negative 0 (neoplasm has a negative hercept-status) and 3+ (hormonal status of the tumor is positive).

Female hormones and tumors

As modern medicine says, most tumors of the female sexual sphere are dependent on the hormonal level of the body. Their development is actively influenced by female sex hormones - progesterone and estrogen. Receptors to these hormones determine the formation and development of cancer. The established hormonal dependence allows to define the scheme of treatment with the subsequent vital prediction quite clearly. In addition, these receptors play a role not only in breast cancer, but also in such serious problems as female infertility, endometriosis and cancer of the genital area - the uterus, ovaries, cervix. The herceptor-status of the tumor, which is established during IHC- examination of the endometrium, for example, will make it possible to prescribe treatment with precisely those drugs that will help to achieve an adequate result without unnecessary experiments with the selection of medicines in each specific case.

If infertility

Infertility is a huge problem for many modern families. Studies conducted by scientific medical institutions showed that in a rather large number of cases infertility is due to a lack of hormonal endometrial background - the epithelial layer lining the uterine cavity. It is the hercept-status that allows one to identify the IHC- study of the receptivity of the endometrium. Female sex hormones are active parts of the process of egg formation, fertilization, implantation of the embryo into the uterine cavity, and subsequent gestation of pregnancy and childbirth. The endometrial ischemic endometrial examination, as we have said, makes it possible to identify the herceptive status of endometrial cells to estrogen and progesterone and, in accordance with the results obtained, to select the right treatment for a woman.

Diagnosis of lymphoma

Oncological diseases are the misfortune of mankind. Although modern pharmacology and technical developments can cure these diseases. But diagnostics are very important here, especially in the early stages of the disease. Lymph oncology is a common problem. IGH-examination with lymphoma is one of the ways to make an accurate diagnosis, then to prescribe adequate therapy. This study is conducted on a biopsy specimen of the lymphatic fluid or tissue of the hematopoiesis system. The material, taken for examination, undergoes staining with special substances that help determine oncomarkers. Unfortunately, this type of research is imperfect and in most cases supplemented by other diagnostic methods. In addition, often the lymphatic system itself does not cause the problem. This is what makes it possible to identify IHX-examination of lymph.

IHC analysis - timely knowledge

Health problems must be detected and identified on time. To do this, we need all kinds of methods for examinations, analyzes. исследование - один из наиболее распространенных методов диагностики новообразований или других проблем с тканями различных органов. IGH- study is one of the most common methods of diagnosing neoplasms or other problems with tissues of various organs. The IHC study is conducted on the material taken to determine the problem - the so-called biopsy. The material is stained with special substances for each specific purpose, and with the help of a visual comparison conducted by a doctor-histologist, oncomarkers are installed that show one or another problem. The imperfection of immunohistochemical research is that the material may not be sufficient, the human factor will play a role, or external causes will not allow to establish an accurate picture of the problem. исследование. In any case, for an adequate diagnosis of the disease, especially oncological, it is necessary to conduct a whole complex of surveys, where one of the steps will be the IHC study. какого-ибо органа, ткани? What is it with the cancer of some organ, tissue? The biopsy is examined for tumor markers, which allow to assess their presence in the sample. As assistance in diagnosing IHH-study is irreplaceable, it is also actively used in establishing the causes of female infertility.

Medicine, including diagnostics, is constantly evolving. Perhaps in the near future immunohistochemical research will be brought to perfection and will allow many people to put an adequate diagnosis with the least expenditure of time and effort.