Formethine: instructions for use, reviews

Currently, there are more and more people suffering from diabetes and obesity of a complicated type. A lot of drugs for the treatment of these ailments. One of them is the medicine Formetin. About its characteristic features will be told in this article.

Pharmaceutical category

Formethine, the instruction for use of which is given in this article, is a hypoglycemic agent of the biguanide group.

Description of the composition and form of release

One of his tablets contains:

The product "Formethin" is produced in blisters for 100, 60 or 30 tablets.
The color of the tablets is white, and the shape depends on the dosage of the basic substance. At 500 mg they have a flat-cylindrical round shape with a risk and a facet. Also, the dosage of 1000 mg and 850 mg is Formethine. Tablets in this case are convex and oval. They are with one-sided risk.

Pharmacodynamics

Metformin (Formethin) slows the gluconeogenesis that occurs in the liver, and there is a decrease in the glycogen reserve. This drug helps to make it difficult to absorb glucose from the intestine, to increase the excretion of sugar from the circulatory system. In this case, the response of tissues to insulin increases, without affecting the production of its endocrine part by the pancreas in B cells, bypassing the hypoglycemic reaction, since production of this substance is not activated.

The drug Formetin, reviews of which speak of its effectiveness, reduces the amount of "bad" cholesterol and triglycerides in the blood. The content of high-density lipoproteins increases by 20-30%. With an ineffective diet, the Formetin drug, the instruction for which is described in this article, helps to reduce and / or stabilize the patient's weight. This is due to oxidation of glucose by anoxic route, as well as a decrease in appetite. Also, the process of activation of tissue plasminogen is dulled by affecting its inhibitor, with a hemostatic effect.

Pharmacokinetics

The assimilation of metformin begins in the gastrointestinal tract. The maximum content of this substance in the blood is reached approximately 2.5 hours after application at a standard dose of 50-60%. The quality of absorption of the drug in the body affects the relationship between the active substance and proteins in the plasma. Forminate tablets do not have a connection with plasma proteins. This indicates its effectiveness. Since the lower the binding factor, the better the drug is absorbed. Deposit is in the kidneys, liver, muscle tissue, salivary glands. In the body, metformin does not undergo changes. It is subsequently excreted by the kidneys. Therefore, if their work is disrupted, cumulation is observed. The half-life of the biological is 1.5-4.5 h.

Purpose

The medicine "Formethin" is used to treat a certain category of diseases. Namely, in the presence of type 2 diabetes, in cases with complicated obesity, when the diet does not help to keep the sugar level in the norm, even in combination with sulfonylurea. Also effective is Formethin for weight loss.

How to use?

The dose of this remedy is chosen by the doctor, based on the amount of glucose in the blood. Oral reception should be performed after meals, washing with a lot of liquid and not subjecting the tablet to mechanical treatment. As already mentioned above, the dosage is given depending on the glucose level in the blood. It begins with a minimum of 0.5 g or 0.85 g per day. Two days after the start of treatment with this drug, there is a constant content of metformin in the blood. If necessary, you can gradually increase the dose to the maximum value. It is equivalent to 3 grams.

Since the lactoacidosis is often observed in elderly people, the maximum daily dose level is 1 g. Also, the amount of the drug is reduced when metabolism is disturbed, to prevent an allergic reaction manifested as a skin rash, and with other possible side effects that will be stipulated below.

Contraindications

In this regard, there are many nuances. The drug Formetin, the instruction for its use is given in this text, is contraindicated if:

• Diabetic ketoacidosis, precoma, coma.
• Expressed violations of the functionality of the kidneys.
• Heart and respiratory failure.
• The acute phase of myocardial infarction.
• Dehydration.
• Chronic alcoholism and other conditions that can contribute to the development of lactic acidosis.
• Acute circulatory disturbance of the brain.
• Pregnancy and breastfeeding.
• Increased sensitivity to this relationship.
• Serious surgical operations and injuries, when insulin therapy is prescribed.
• Severe infectious diseases.
• Violations of the functionality of the liver.
• Acute alcohol poisoning.
• Lactic acidosis (including in history).
• Diets hypocaloric (less than 1000 kcal per day).
• X-ray or adi-isotope studies with the introduction of an iodine-containing substance.

Also, Formethine is not recommended for people over sixty years of age who perform physical hard work. Since in this case they have an increased risk of developing lactic acidosis.

Side effect

The appearance of such unpleasant symptoms as "metallic" taste in the mouth, vomiting, nausea, diarrhea, gas formation, lack of appetite requires the cessation of the use of therapy and immediate treatment to a specialist. Prolonged use of the drug causes a violation or complete cessation of absorption of vitamin B ₁₂ , which leads to accumulation in the body of the latter, causing hypovitaminosis. In rare cases, the reverse develops - megaloblastic В _12- deficiency anemia. If the dose is incorrect, hypoglycemia is possible. Also, allergic reactions may occur in the form of skin rashes. Therefore, the drug "Formethine", whose reviews on its usefulness in application are different, should be appointed only by the attending physician.

special instructions

Important criteria are determined by the peculiarity of the accumulation of the main substance "Formethan" in the body and the consequence of this.

To prevent cumulation of metformin and prevention of lactic acidosis, it is necessary to monitor the indicators of kidney function and to submit tests for determining the content of lactic acid in the body at least 2 times a year. Also, if muscle pain occurs, a second examination should be performed.

The effect of this drug on the ability to control mechanisms and driving vehicles

In this case, there are also certain nuances. The influence of Formetin on the ability to control mechanisms and transport takes place only if it is used together with drugs that affect work processes, which require rapid response and increased concentration of attention. This is important to know.

Application in breastfeeding and pregnancy

The drug Formetin, the instructions for use of which is set out in this text, has a category of effects on the fetus "B" by the FDA. In pregnancy, you can take this medication. However, its use can be only in certain cases. Namely - when the expected result from this therapy will exceed the presence of a potential risk to the fetus. Certain and specific studies on the use of such a drug as Formethin were not performed during the gestation period. At the time of treatment should stop breastfeeding. In any case, you need to seek the advice of a qualified doctor.

Drug Interactions

Metformin increases the level of sugar in the blood. This is especially manifested with simultaneous administration with non-steroidal anti-inflammatory agents, sulfonylurea derivatives and clofibrate, monoamine oxidase inhibitors, acarbose, insulin, oxytetracycline, cyclophosphamide, inhibitors of adrenoblockers and an angiotensin-converting enzyme.

When used together with endocrine drugs (oral contraceptives, glucocorticosteroids, sympathomimetics, epinephrine, thyroid gland hormones, glucagon, thiazide and loop diuretics, phenothiazine derivatives, nicotinic acid derivatives), metformin inhibition of the hypoglycemic process is possible.

With a combination of such drugs as Formethin, with Tzimidine, Nifedipine, there is a risk of lactic acidosis, which inhibits the excretion of metformin from the body. This is observed when taking alcohol-containing products, including in the composition of medicines.

Cationic agents (quinidine, amiloride, digoxin, procainamide, morphine, quinine, vancomycin, ranitidine, triamterene) formed in tubules compete for transport systems and, with prolonged treatment, can increase the drug concentration to 60%.

Overdose

Overdose of Forminom was observed with the intake of 0.85 grams per day and provoked lactic acidosis. Also, the high content of metformin is due to improper functioning of the kidneys.

The earliest symptoms of lactic acidosis are weakness of the whole body, bloating, lowering of body temperature, pain in the stomach and muscles, lowering of arterial pressure, reflex bradyarrhythmia. In some cases, there are manifestations of frequent respiration, impaired consciousness, dizziness and, as a consequence, coma develops.

At the slightest appearance of symptoms of an overdose, it is necessary to stop using the drug and consult a doctor to confirm the diagnosis of lactic acidosis. To remove the active substance of this agent and lactic acid from the body will help hemodialysis with parallel symptomatic treatment.

Formethine: Analogues

There are many tools of this type. Analogues of Formetin are preparations containing in their composition as the main component of metformin hydrochloride. As an example, we can mention the medicines of Russian manufacturers: Vero-Metformin, Gli-formin, Metformin, Metformin-Richter, and foreign ones - Glucophage, Glucophage and Glucophage Long (France), Langerin "(Slovakia)," Metfogamma "with different dosages of the active substance 0.100, 0.500 and 0.850 g (Germany).

Terms and conditions of storage

In this regard, there are certain conditions. The drug Formetin is potent, so it is released only on prescription and requires storage at room temperature, in a place inaccessible to children and sunlight. She has a shelf life of 2 years.

Cost

The average price for the drug Formetin is set depending on the dosage: from 59 rubles. For blister 0,5 g, 133 rubles. For 0.85 g and 232 rubles. For 1 g.

Conclusion

All of the above contains a lot of useful information. After reading this article, everyone can find an answer to the question of how to take Formetin and what properties it has.