Cream for acne "Tretinoin": reviews. "Tretinoin" how effective?

Skin problems worry many people. They not only spoil the appearance of a person, but can lead to more serious diseases and complications. To effectively combat them, you need to find the right medicine. Means for acne on the face are unequally effective for everyone. Only a dermatologist's examination will help to choose the right treatment.

"Tretinoin" from acne has already helped many. This tool has the necessary properties that allow you to cope with lesions of the skin. Before starting the use of the drug it is worth consulting with a specialist about possible negative consequences and to consider in detail the action of "Tretinoin", release forms and analogues.

Forms of release "Tretinoin"

Means for acne on the face are of several types. Many of them are produced under the same name, which helps to choose the most convenient to use tool. Not an exception and "Tretinoin". The price of the drug may also depend on its form.

"Tretinoin" comes in the form of a cream, lotion, gel, solution and capsules. "Tretinoin" -lion is designed to cleanse the skin of contaminants, relieve inflammation and get rid of acne and other types of acne. This form is ideal for caring for young skin, normalizes the work of the sebaceous glands, which helps get rid of fatty shine.

"Tretinoin" -cream is more suitable for older people, with signs of aging of the skin. The cream has a fatty basis, due to which it helps to smooth out age wrinkles. This cream is an anti-inflammatory drug that effectively fights most skin and subcutaneous tissue problems.

The gel has a lighter structure in comparison with the cream and is suitable for oily and combination skin types. Like the cream, has an anti-seborrheic effect. Capsules "Tretinoin" are used to induce remission in acute promyelocytic leukemia and should be administered exclusively after an accurate diagnosis. Treatment with capsules "Tretinoin" should be under the supervision of an oncologist and hematologist.

The solution has the same pharmacological effect that the cream and lotion. It is used not only to solve visible skin problems, but also can draw out hidden acne. It is used in the complex treatment of various types of acne.

Structure of the preparation

"Tretinoin" -cream has in its composition an active substance - transretinic acid (tretinoin) in an amount of 0.05% or 0.1%. The higher the mass part of the active substance, the more effective the effect of the drug. Tretinoin is a powdery substance of a yellow or light orange hue, so the cream contains auxiliary products that create a water-oil and oil-water base.

Gel "Tretinoin" has in its composition the active substance in an amount of 0.1%, 0.025% or 0.05% of the total mass. In addition to tretinoin, the gel also contains propylene glycol, carbomer, isopropyl alcohol, triethanolamine, butylated hydroxytoluene and some other substances in a small amount.

"Tretinoin" -zone with zinc is released with an active substance concentration of 0.05%, and a solution with 0.1%. Also in the lotion are propylene glycol and ethyl alcohol, which have a bactericidal effect.

Each capsule of "Tretinoin" contains 10 mg of active substance and such auxiliary substances as beeswax, soybean oil. The gelatin capsule shell contains glycerol, carion-83, titanium dioxide and colorants.

Indications for use

The drug belongs to the group of retinoids, in structure close to vitamin A. It is obtained as a result of metabolism of retinol. Tretinoin has anti-seborrheic, antitumoric, keratolytic and comedogenic effects. In addition, it stimulates the regeneration of tissues, strengthens the immune system, and also has a local anti-inflammatory effect. It is used to treat draining and vulgar acne. In the form of capsules, the drug is effectively used for remission of myeloleukemia.

"Tretinoin" -cream is used to suppress cutaneous inflammatory processes and has a general beneficial effect on the upper layer of the epidermis. Can be used to treat certain types of dermatitis and other skin diseases.

Acting Action

"Tretinoin" -cream (from acne) allows to remove inflammatory processes in different layers of the epidermis, it is applied externally, but it has a deeper effect. The active substance influences the formation of skin cells by elastin, which increases the elasticity of the skin and helps to reduce the appearance of wrinkles and other age-related changes.

Tretinoin affects the production of melanin, suppressing the process of its formation in large quantities, which leads to a reduction in the risk of malignant tumors. It also stimulates the growth of epithelial cells and activates the processes of their division, which contributes to the restoration of skin.

In the treatment of open acne, the remedy balances the upper layer of the epidermis without leaving scars and other signs of tissue damage. On closed eels, the drug has a pulling action that leads to their opening and further removal, while reducing inflammation and preventing tissue scarring. Also prevents new occurrences of acne.

Anti-seborrheic effect of the drug "Tretinoin" -cream is to prevent the growth of epithelial cells, the normalization of the sebaceous glands, the reduction of inflammatory processes in the locations of sebaceous ducts.

The effect of using the drug manifests itself after one and a half to two months. After one to two weeks of use, there may be an increase in the number of acne. This occurs in the process of bringing out and opening the hidden eels.

Capsules "Tretinoin" are intended for oral administration. They are prescribed only to those patients who have an abnormal level of formation and accumulation of promyelocytes, which leads to myeloid leukemia. Tretinoin inhibits the process of accumulation of myeloid cells, which leads to remission, which can last from two to four months.

Contraindications

Sensitivity to the active substance of the drug is a sufficient reason for its inability to use. You can not also use "Tretinoin" during pregnancy, as this can lead to embryonic developmental disorders. During the period of breastfeeding, you should not use the drug orally.

The agent is not assigned to patients with acute inflammatory processes on the skin, the presence of cutaneous injuries in the form of wounds or burns. It is also unacceptable to prescribe the drug to patients with skin epithelioma or having a family predisposition to it. You can not use the drug for various types of eczema, pancreatitis, diabetes mellitus and increased intracranial pressure.

The drug has age limits. It is not administered orally to children under one year of age, externally to the age of twelve, and in any form to patients older than fifty.

Side effects

When taking the drug orally, a "retinoic acid syndrome" can develop, which can lead to serious consequences.

When the first symptoms appear, you should immediately appoint the appropriate treatment. Symptoms of the syndrome are the appearance of dyspnea, hyperleukocytosis, hypotension, fever, renal and hepatic polyorganism insufficiency.

When using the forms of "Tretinoin" for external use, there may be various skin reactions (ecdysis and dryness), rashes, itching, subcutaneous hemorrhages. Also, reactions such as dry mouth, increased sweating, sensitivity to ultraviolet rays, alopecia, hyper- and hypopigmentation may occur.

In some cases, there are abnormalities in the digestive tract (nausea, vomiting, diarrhea), central nervous system (depression, dizziness, hearing and vision disorders, increased intracranial pressure).

Disturbances in metabolic processes due to taking the drug are expressed in a change in body weight and the appearance of cellulite, as evidenced by the reviews. "Tretinoin" can also lead to the emergence of respiratory tract infections, accompanied by coughing, shortness of breath, swelling of the mucosa and larynx, wheezing in the lungs.

Some patients, after taking the drug, observed arrhythmia, pain in the muscles, chest and back, general weakness of the body and drowsiness. With the development of several side effects or the emergence of a threat of complications from taking the drug, the patient may be assigned full refusal of treatment or reduction of the initially recommended dosages. There is a possibility of replacing "Tretinoin" with analogs.

Instructions for use

"Tretinoin" (cream or gel) should be applied with a thin layer of rubbing movements only on the affected skin areas once a day and leave for six hours. After this time, it is recommended to rinse the product with water. It should be remembered that exceeding the dose will not lead to a more rapid result.

Owners of light skin or dry skin are recommended to start leaving the drug for only half an hour. With a normal skin reaction, time can be gradually increased. Aging pustules and comedones can be removed during treatment. The course of treatment varies from two weeks to three months and depends on the degree of skin damage and the susceptibility of the body to treatment.

The daily dose of the drug "Tretinoin" in capsules should not exceed 45 mg per square meter of skin. The course of treatment is three months. Dosage is the same for all ages not indicated in contraindications. When diagnosing a patient for renal or hepatic insufficiency, the dose should be reduced to 25 mg.

The maximum permissible daily intake for an adult is 195 mg of drug per square meter of skin and 60 mg for a child. With extensive tumors, the daily dose can be increased to a third of the maximum allowable.

When using drugs containing tretinoin, avoid prolonged exposure to direct sunlight. In case of tanning, the patient should postpone the treatment until the skin is naturally brightened.

Interaction with medicinal products

Drugs that affect the activity of hepatic enzyme production, significantly reduce the effectiveness of the drug "Tretinoin Retin A." Stimulants for the production of liver enzyme activity include glucocorticosteroids, rifampicin, pentobarbetal, and phenobarbital. Suppress the activity of hepatic enzymes Verapamil, Erythromycin, Ketoconazole, etc. Experts say that "Tretinoin" does not affect the effectiveness of these drugs, as evidenced by research and their reviews. "Tretinoin" reduces the effectiveness of contraceptives in tablets based on Progesterone (mili-drank).

Caution should be exercised with the simultaneous use of "Tretinoin" and the use of antifibrinolytic drugs, as some patients experienced thrombotic complications with a fatal outcome.

A special feature of the action of "Tretinoid" is a possible increase in intracranial pressure. The same effect is observed in tetracycline drugs, so do not use these drugs at the same time.

"Tretinoin": analogues

To solve problems with the skin there are several similar tools that also do a good job of their task. "Tretinoin," whose price is high enough, for some reason may not be suitable (individual sensitivity and other contraindications) for a particular person.

"Retinoic ointment" is a cheaper analogue of "Tretinoin" and in its composition has vitamin A and isotretinoin. If you misuse the ointment and disobey the instructions, you can get a skin burn. Initially, the remedy was intended to combat acne and other eruptions, but during use it was found that the ointment, with a short-term effect, activates the production of collagen and thereby smoothes out shallow wrinkles.

"Differin" in its composition has the active substance adapalene, which is a synthetically derived analogue of retinoic acid. Has a softer effect in comparison with "Tretinoin". Also available in the form of a gel for oily skin and as a cream for dry skin type. The drug is not intended for getting rid of neoplasms and seborrheic dermatitis. The presence of these diseases is a contraindication to the use of "Differin", since it requires more powerful means.

Price of the preparation

"Tretinoin" -cream, the price of which depends on the form of release of the drug and its manufacturer, is quite popular for solving skin problems. Drugs are supplied to Russia. This is evidenced by numerous reviews. "Tretinoin" in the form of a cream or lotion with zinc of Italian production is called "Airol". It has a more affordable price compared to other manufacturers, an average of 2500 rubles per 50 ml lotion or 30 mg cream.

"Lokatsid" - it contains tretinoin cream, the price of which is only 1500 rubles. Under this name, one can also find a solution for external use with tretinoin. But, according to the patients, has less effective effect or requires more cream.

Under the name "Retin-A" you can find "Tretinoin" -maz and gel of Indian manufacture. "Vesanoid" - capsules with tretinoin of Swiss origin. Their cost per package of 100 pcs. Is more than 10 000 rubles, but one package is enough for the course of therapy.

Feedback on application

"Tretinoin" is considered one of the best solutions for getting rid of many skin problems. In the absence of contraindications, one can expect excellent results and smooth skin after a few weeks of using the drug. The agent may not be recommended by specialists due to a wide range of side effects and contraindications, as evidenced by numerous reviews. "Tretinoin" should only be used under the supervision of a doctor. Self-application can be fraught with consequences.

"Tretinoin" against wrinkles also has its contraindications to use, unlike cosmetic products it can not be used without consulting a specialist who will choose the optimal dosage and duration of the course of use.

Those patients who used the drug to get rid of acne and acne, note its beneficial effect on the skin of the face and body. Patients testify to a healthier skin appearance within a couple of weeks after the start of the use of the drug. Also, a long-lasting effect was noted, which makes it rare to use the drug and minimize the side effects of the drug. In comparison with other similar drugs, "Tretinoin" has a fairly rapid effect and allows you to quickly get rid of the problem or make it less visible.

Many other drugs that can be purchased at the pharmacy, is designed to get rid of pimples, wrinkles and the solution of various skin problems. They are much easier to buy, because they are much cheaper, but they do not have such an effect as "Tretinoin". This drug has proved to be one of the best in the fight against skin problems.