Budesonide: instructions for use and analogues. Budesonide for inhalations: reviews, price

Bronchial asthma ranks first in the world among diseases associated with the hyperactivity of the immune system. For its treatment, a huge number of drugs are created. One such means is Budesonide. Analogues of this drug are also often used to treat bronchial obstructive syndrome. So what is this medicine?

What is Budesonide?

This drug belongs to the group of inhaled glucocorticoids. This remedy is a synthetic analogue of hormones synthesized in our body (in the adrenal cortex). What is the action of Budesonide?

Instruction for the use of the drug suggests that this drug helps increase the number of active beta-adrenergic receptors in the airways.

In addition, the drug blocks the action of inflammatory leukotrienes and prostaglandins, thereby preventing the development of the inflammatory process in the bronchial mucosa.

It has its effect after daily intake for several days (usually about 5-7 days).

It is one of the main drugs for the treatment of severe bronchial asthma and chronic obstructive pulmonary disease. At the initial stages of development of these diseases is not applied.

How does Budesonide affect target cells?

Pharmacodynamics

The drug, thanks to inhalation, is well absorbed from the surface of the lung (from the surface of the mucous membrane of the nose practically does not enter the systemic bloodstream).

The maximum concentration of the drug in the blood plasma is observed 45 minutes after its inhalation. 85 percent of the whole drug comes in contact with the blood albumin, the remainder is unchanged.

It is processed in the liver. It is excreted from the body through the gastrointestinal tract (with bile) and with urine.

In patients with pathology of these organs, there is a longer delay in the drug in the blood, which is associated with the development of most complications and overdose of glucocorticoid hormones.

You can use the drug in a tablet form for the treatment of systemic collagenoses (however, only 10 percent of the total amount of the drug in the digestive tract can have a therapeutic effect).

It is also used to treat non-inflammatory diseases of the nasal mucosa due to prolonged local action.

Indications for use

In what cases can I appoint Budesonide? Instructions for use lists the main diseases in which these drugs can be used:

• Bronchial asthma. The drug was spread due to its anti-inflammatory effect and the ability to inhibit the activity of inflammatory mediators.
• Crohn's disease. To treat this disease, a tablet form of the drug is used. The drug is prescribed for the purpose of inducing remission in light and moderate forms of the disease.
• Treatment of rhinitis. The appointment of an intranasal form of budesonide for relief of symptoms of hay fever and allergic rhinitis is indicated. An excellent tool for treating this disease is Budesonide formoterol.
• Prevention of recurrent development of polyposis of the nasal mucosa. The drug is used in the early postoperative period. Practically in 95 percent of cases prevents re-development of polyposis.

The listed diseases are the main processes under which "Budesonide" is appointed.

Sometimes this drug can be prescribed to prevent the development of obstructive pulmonary disease. To such cases it is possible to carry patients with occupational diseases or working in harmful working conditions. But it should be remembered that even using medicines for prevention, do not forget about careful dosing of the drug, because otherwise there is a high risk of getting problems with the adrenal glands and glucocorticoid cancellation syndrome .

In what cases is its use contraindicated?

Contraindications

Under what processes and diseases is it forbidden to use Budesonide? Instruction for the use of the drug indicates the following diseases:

• Hypersensitivity to the drug or its components. It is dangerous to develop angioedema.
• Active form of pulmonary tuberculosis.
• Diseases of the respiratory system of fungal nature.
• Acute infectious processes in the gastrointestinal tract.
• Severe hepatic insufficiency.
• Childhood.

For all these diseases, the use of glucocorticoids is prohibited. This is due to the fact that the drug either aggravates the process, or worsens its course. Children should not use this medication because the physiological production of glucocorticoid hormones can be impaired because of the insufficiency of the adrenal cortex.

There are also some limitations, in which extremely careful to appoint "Budesonide." Instructions for use warns that very carefully you should use the drug for people with arterial hypertension, diabetes, pheochromocytoma, callous ulcer of the stomach and duodenum.

Side effect

At the present time, there is no medication that does not develop any side effect. Unfortunately, Budesonide is also a drug with a rather large spectrum of side effects of its action.

If Budesonide is used for inhalations, the main side effects of its use will be speech disorders (dysphonia), hoarseness, dry mouth, cough, development of paradoxical bronchospasm.

With oral intake, it is possible to develop depression, dizziness, irritability.

The cardiovascular system can respond to the introduction of Budesonide with the development of vasculitis, increased systemic BP, tachycardia.

The medicine can cause and exacerbation of diseases of the digestive tract - ulcers, pancreatitis. In addition, it stimulates the development of dyspeptic disorders.

He has a negative influence on the musculoskeletal system. Possible the development of osteoporosis, myasthenia gravis, joint pain.

The most serious side effect is hypercorticoid syndrome. It develops due to the fact that during the period of taking glucocorticoids, the synthesis of its own hormones decreases. If corticoids have been used for quite a long time, the adrenal glands can simply stop synthesizing physiological substances, which will necessarily affect the patient's health. That is why it is important to carefully monitor the doses of incoming hormones, as well as to properly stop their intake.

Dosage of the drug

In what dosages should be prescribed "Budesonide? Instructions for prescribing the drug provides the following dosing regimen.

The use of the inhalation form of Budesonide is based on the severity of the disease. The optimal dose for an adult is 200-800 μg per day. The maximum daily dose should not exceed 1.5 mg. In children, the drug is contraindicated, and its analogues are prescribed according to the severity of the clinical case.

The oral form of the drug is used 30-60 minutes before meals. Use up to 3 mg 3 times a day. The course of treatment with an oral drug is about 2 months. The withdrawal of the drug is carried out gradually to prevent withdrawal syndrome.

Intranasally, Budesonide Ishihler is usually administered. Its dose is selected for each person individually, depending on the severity of the process. On average 2-3 drops of the drug are used in each nostril twice a day. In children this form of the drug is contraindicated. The course of treatment is designed for 2 weeks.

Interaction with other drugs

Some drugs, when used together with Budesonide, can degrade digestibility. These drugs include cytochrome P450 inhibitors. For example, if Budesonide (Pulmicort is used as an analogue) and preparations such as Ketoconazole and Erythromycin are simultaneously slowed, the glucocorticoid can be removed from the blood, which can lead to hormonal intoxication and the appearance of undesirable drug effects.

Parallel reception of Budesonide and some diuretics (Indap) promotes the development of hypokalemia in the patient's body, which will undoubtedly affect the work of the heart.

Some drugs (for example, antacids - "Almagel") with simultaneous use with "budesonide" exert antagonistic effect on each other, i.e. Do not give each other their therapeutic effect. Because of this, it is recommended to use these drugs with an interval of at least two hours (applicable only to the oral form of the drug).

Use of the drug for inhalation

Since this medicine was created primarily for the treatment of respiratory tract diseases, it is worthwhile to figure out how to prescribe them.

Inhalation forms of the drug have been created quite a lot, but their use usually converges in many ways.

First, these medications are usually administered with the help of a nebulizer. This device allows you to enter into the respiratory tract a strictly selected dose of medication. Usually, one dose of inhalation powder is enough to stop the symptoms of asthma or COPD.

For this purpose, Budesonide-native is usually used. This drug is patented by a Russian company. In its composition, the drug carries a suspension (or powder) of Budesonide. The nebulizer is loaded with a cassette with the drug, after which the inhalation agent enters the bronchi and lungs.

Some drugs are available in the form of an aerosol, which also contains Budesonide. Their trade name may differ from each other, but the active substance will be the same glucocorticoid. If you take this drug, remember that one dose of aerosol contains 0.05 ml of active budesonide (this is important to know so as not to cause an overdose of glucocorticoids).

Cost of preparation

Given the size of the current market of medications, it is not difficult to find Budesonide for inhalation. The price for it and its analogs may differ, but it should be remembered that all the same in their composition the main active substance will be budesonide. The cost of the drugs will depend only on who produces this medicine, and whether it is a patented drug or a generic.

The drug is purchased exclusively in pharmacies. How much will Budesonide cost? The price for it and its analogs averages from 300 to 2000 rubles. It all depends on who the manufacturer is, and what form of release the drug is. For example, a preparation such as "Benacort" is available in the form of capsules with powder for inhalation. On average, it costs 400 rubles. English drugs are much more expensive. For example, "Budesonide Formoterol" of British production costs within 2000 rubles, which not everyone can afford. It is easier to buy Slovenian drugs, which do not differ in efficiency, but are much cheaper.

In the conducted studies it was proved that the more expensive drugs are almost in no way inferior to their budget counterparts. Therefore, what drug to buy - the individual choice of each, depending on its needs and security.

Reviews about the drugs

Glucocorticoid drugs have been used for a long time by many patients with chronic obstruction or asthma syndrome. Virtually all patients with severe form of one of the listed diseases are assigned "Budesonide". Analogues of it occupy a rather wide cell in the register of medicines against these diseases, so they also often remain on hearing. These are such medications as, for example, "Apulein", "Benakap", "Buderin", already mentioned above "Pulmicort" and "Benacort", etc.

According to many patients, these drugs are the best in the treatment of respiratory tract diseases. Quite a few people who would not have been helped by the inhalation form of the glucocorticoid or its combination with beta-adrenomimetics.

With proper dosing of the drug, it was possible to achieve a significant improvement in the condition in such patients. Nowadays, many simply can not imagine life and normal life without using these medicines.

However, despite numerous positive reviews, there is also the dark side of such a drug as Budesonide - the price.

For a long time there was a tendency to free prescription of antiasthmatics to needy patients. All patients could come to the pharmacy and, upon presentation of an appropriate document, receive a free drug for their own needs.

At present, this is also practiced, however, the contingent to whom these drugs are prescribed for free has significantly narrowed. Now such medicines are given free of charge only to people with disabilities of 2 and 1 groups, as well as children; Others are forced to purchase medicine for their own money. Given that the drug requires quite a lot, not everyone can afford this treatment.