Zokor drug, instructions for use, medical research data

"Zokor" is a medicine that belongs to the clinico-pharmacological group of lipid-lowering drugs. The active substance of the preparation Zokor is simvastin, 10,20 and 40 mg, as well as auxiliary ones: ascorbic and citric acid, butyl hydroxy anisole, talc, magnesium stearate and some others can be contained in one tablet.

"Zokor" is a highly effective agent that provokes a general decrease in cholesterol in the body. This is especially important with mixed hyperlipidemia, because with this diagnosis, its elevated content is considered a risk factor. During the period of 2 weeks you can achieve a noticeable positive dynamics, the therapeutic effect is kept at the maximum level for 4-6 weeks. The cholesterol level returns to its initial values when Zocor is discontinued, the instructions for use contain some research data on the drug.

The monitoring of patients in the number of about 4.5 thousand people was carried out for 5.4 years. All patients had a cholesterol level (mg / dl), 212-309. Zokor's intake reduced the risk of death by 30%, the number of myocardial infarctions by 37% (cases confirmed in the clinic), 42% - death from IHD. In 37 patients out of 100, there was no need for surgical intervention to normalize coronary blood flow.

In the UK, 5.5 years, a study of patients (20536 people) was conducted in which CHD was observed or predicted. In the third part of the study, the risk of strokes and heart attacks was reduced to a minimum. At what, the initial level of cholesterol, parallel therapeutic treatment, sex and age of patients did not affect the effectiveness of taking Zocor. The instructions for use describe in detail its pharmacokinetics, before it enters the blood it is absorbed from the digestive tract. The high accumulation of simvastin in the liver was experimentally demonstrated, in other organs its concentration was found in much smaller quantities, the active substance with bile is excreted.

Ischemic heart disease is the main indication for the appointment of the drug "Zokor", the instruction for use calls several purposes for its use:

- preventive measure against myocardial infarction;

- slowing down the process of coronary atherosclerosis;

- Stabilization of cerebral circulation, reduced risk of stroke.

With an increased level of cholesterol, taking Zocor helps reduce it, and if the diets are ineffective, as well as other non-pharmacological activities, when hypercholesterolemia has developed into a risk factor, it is advisable to prescribe this drug.

At the stage of exacerbation, liver failure refers to contraindications for taking Zocor. Instructions for use also do not recommend the use of the drug during pregnancy or breastfeeding, as well as when there is an increased sensitivity to the components of the drug.

"Zokor" causes some side effects on the part of the digestive system. When taking Zocor, the instruction indicates possible constipation, abdominal pain, information about cases of hepatitis, pancreatitis, jaundice.

Side effects are observed in relation to the central nervous system, these are muscle cramps, dizziness, peripheral neuropathy.

Rarely, but allergic reactions occur in the form of angioedema, vasculitis, lupus-like syndrome, arthritis, increased ESR, fever, dyspnea, eosinophilia.

In cases of overdose, no adverse adverse events were found, the maximum accepted dose is 450 mg.

Store the drug "Zocor" is recommended at t maximum of 30 degrees, even temporary exposure t of about 50 degrees should be avoided.