"Z-factor": reviews, instructions for use, side effects

The drug "Zi-factor" instructions for use defines as a bacteriostatic antibiotic, belonging to the group of macrolides-azalides. The drug has a broad spectrum of antimicrobial effects. The mechanism of activity is associated with the suppression of protein synthesis in microbial cells, thereby slowing the growth and multiplication of bacteria. Antibiotic "Zi-factor", reviews of patients and specialists about which are often positive, effective against intra- and extracellular gram-negative and gram-positive, as well as some anaerobic organisms. Meanwhile, pathogens can initially be resistant to a medicine or acquire this stability during the use of a medicine.

Pharmacokinetic properties

The active ingredient of the drug "Zi-factor" instructions for use calls azithromycin. It is perfectly absorbed, in the body is distributed quickly. After a single intake of 500 milligrams of the drug, bioavailability is 37 percent, after two to three hours, the plasma produces the highest concentration, 0.4 milligrams per liter. The drug "Zi-factor" penetrates through the cell membranes and is transported by phagocytes to the site of infection, where in the presence of the pathogen is released. The drug easily passes the histohematological barriers. In tissues and cells, the concentration is ten to fifty times higher than that observed in plasma, at the same time in the foci of infection it is on average 24-34 percent higher than in healthy tissues. Getting into the liver, the drug is demethylated, while losing activity. After intake of azithromycin in the therapeutic concentration is maintained in the body for five to seven days, is excreted mostly unchanged in the intestine (50 percent) and kidneys (6 percent).

Indications for use

The drug is effective in infectious inflammatory diseases caused by microorganisms susceptible to the drug. So, apply the drug "Zi-factor" for sinusitis, sinusitis, tonsillitis, otitis media, pharyngitis and other pathologies of ENT organs and upper respiratory tract. Assign a medicine and for diseases of the lower respiratory tract: bronchitis, pneumonia, including caused by atypical pathogens. Use the medicine "Zi-factor" instruction for use recommends for infections of soft tissues, skin: dermatoses, erysipelas, impetigo; Infections of the genitourinary tract: cervicitis, urethritis.

Form of issue

The drug is produced in the form of tablets and capsules. Tablets "Zi-factor" biconvex, oblong, covered with a light pink coat. Packed in three-pack boxes. Capsules of white color, hard, gelatin; The contents are a mixture of powder and granules. Packed in 6 or 10 pieces in the cell blisters.

Composition

In one tablet, the active ingredient - azithromycin (in the form of dihydrate) - is present in an amount of 500 milligrams, and in one capsule - 250 milligrams. As auxiliary components, povidone, magnesium stearate, calcium phosphate dihydrate, sodium lauryl sulfate, crospovidone, talc, titanium dioxide, red acid dye, hydroxypropylmethylcellulose, polysorbate are used in the tablet formulation. Secondary substances in the capsules are cornstarch, sodium lauryl sulfate, methyl parahydroxybenzoate, lactic sugar, acetic acid, lactopress, aerosil, magnesium stearate, povidone, titanium dioxide, gelatin and propyl parahydroxybenzoate.

Application features, dosage

The medicine should be taken orally once a day, one hour before a meal or two hours after. When respiratory tract infections, ENT organs, soft tissues and skin are prescribed a daily dose of 500 mg, therapy lasts for three days. The course of treatment for migrating erythema is as follows: on the first day, take 1000 mg, from the second to the fifth day - 500 mg daily. In uncomplicated cervicitis or urethritis should be taken once 1000 mg of the drug. Patients with moderate impaired renal function are not required to adjust the dose.

Adverse events. Reviews

Concerning the occurrence of negative reactions after taking Zi-Factor medication, the reviews are different. Quite often, patients complain of diarrhea, nausea, vomiting, abdominal pain, digestive disorders, drowsiness. Some patients report such side effects as dizziness, convulsions, headaches. In rare cases, there is hyperactivity, nervousness, noise in the ears, hearing problems, impaired perception of smell and taste. In the instructions for use among possible side effects , such as paresthesia, asthenia, anorexia, pseudomembranous colitis, liver necrosis, arrhythmia, thrombocytopenia, nephritis, neutropenia, vaginitis, arthralgia, photosensitivity, angioedema, hepatitis, toxic epidermal necrolysis, erythema multiforme . Individual patients testify to the emergence of aggressiveness and anxiety after using the drug "Zi-factor." Reviews, among other things, contain information that the medicine is capable of provoking a discoloration of the tongue, constipation, skin rashes and itching.

Contraindications

It is forbidden to use medicines for people with hypersensitivity to macrolides, with severe impairment of kidney / liver. Zi-factor is not prescribed for children under the age of twelve. Also, you should not take the drug to women during the lactation period, along with dihydroergotamine and ergotamine, patients with lactase deficiency, genetic intolerance to galactose, glucosogalactose malabsorption. With caution, prescribe medication to people with moderate disorders of kidney / liver, arrhythmia or predisposition to it. In pregnancy, the drug is used only if the expected benefit for the mother is greater than the likely risk for the development of the fetus.

Overdose

Diarrhea, nausea, vomiting can develop if you take in excessive doses of the drug "Zi-factor." Individual testimonials indicate the appearance of a symptom such as temporary hearing loss. In case of an overdose, symptomatic therapy is prescribed.

Interaction with other drugs

Antacids reduce the concentration of azithromycin by 30% in plasma, so the Zi-factor medication should be taken at least one hour before or two hours after using these drugs and food. The concentration in the plasma didanosine, methylprednisolone, carbamazepine, rifabutin in a joint application of azithromycin does not affect. However, its effect on the concentration of cimetidine, indinavir, triazolam, fluconazole, midazolam, efavirenz, trimethoprim can not be ruled out. If you need to use the drug "Zi-factor" at the same time as cyclosporine or digoxin, you should monitor the blood plasma levels of the latter, and when combined with warfarin it is recommended to carefully monitor prothrombin time. Simultaneous administration of azithromycin and terfenadine can lead to arrhythmia, as well as to the prolongation of the QT interval.

special instructions

In case the patient forgot to drink the medicine, it is necessary to take the missed dose as soon as possible, and the subsequent ones - with an interval per day (24 hours). When treating azithromycin, as with any antibiotic therapy, there is a risk of joining superinfection, including fungal. To treat tonsillitis and pharyngitis caused by Streptococcus pyogenes, and for the prevention of rheumatic fever, penicillin is usually prescribed. It should be noted that azithromycin is effective against streptococcal infection, but it is not suitable for the prevention of rheumatic fever.

The medicine "Zi-factor". Analogues

At once it is necessary to say that the "Z-factor" remedy is not an original preparation. This is the domestic generic medicine "Sumamed", developed in 1980 by specialists of the Croatian pharmaceutical company "Pliva". To date, there are numerous analogues of Sumamed for sale: along with the drug Zi-Factor, they include such drugs as Azitrox, Hemomycin, Azitsid, Sumatrolide solutab, Zitrolide, Azivok "," Safotsid "," Azitral "," Sumamox "," Sumamechin "and others. So is there a difference in what to take: the generic "Zi-factor" or "Sumamed", which is the original drug? There is no single answer to this question. According to the pharmacological properties of these drugs are identical, the difference is only in the manufacturer and price. However, many patients believe that the analogue is by definition worse than the original, because it does not conduct clinical trials and trials. If you focus on the price, it is better to buy the "Z-factor": the price of six capsules averages 171-187 rubles, while for six capsules of "Sumamed" you have to pay 448-530 rubles.

Opinions of patients about the preparation "Zi-factor"

People's comments about the drug are mostly good. Most of those who have used the drug, among its merits, are noted for high efficiency at a relatively low price. Patients testify that the drug is especially good for angina. She feels much better the next day after taking the medication, has a sore throat, cough, joint aches. Also, the medicine effectively relieves sinusitis: on the second day of treatment, nasal congestion is eliminated, and headaches cease. Meanwhile, not all the reviews are so positive. Some people talk about the development of a strong digestive disorder against the background of taking Zi-factor. Individual patients note that after taking capsules / tablets, they began to feel bad: symptoms such as nervousness, lack of air, rapid heartbeat, anxiety, a sense of fear appeared. In such situations, you should stop taking the drug and seek help from a specialist.

Additional Information

The drug "Zi-factor" from pharmacies is released on prescription. The drug does not influence the ability to control mechanisms and vehicles. Shelf life from the date of release is two years, the medicine should be stored out of reach of children and protected from exposure to sunlight at a temperature not exceeding 25 degrees Celsius.