The drug "Depot-Provera"

Depo-provera is an injectable progestin (gestagen) of prolonged action. High dosages of the drug can have an antitumoral effect on hormone-sensitive malignant formations. This effect is presumably due to the effect on hormone receptors (steroid) and pituitary-gonadal axis. The medication also has a pyrogenic effect (the ability to raise the temperature), in significant doses has the activity of a corticosteroid. The drug has a progestin property, has no estrogenic and androgenic activity.

Depo-probe is slowly absorbed after intramuscular injection. In this regard, constant concentrations of medication are maintained for a long time. The maximum content in the blood (plasma) is noted on the fourth to the twentieth day after the injection. Residual concentrations can be detected even after seven to nine months after use.

Depo-probe penetrates into breast milk and through the blood-brain barrier. Metabolized medicine in the liver. It is excreted in urine and bile in unchanged form and in the form of metabolites.

Indications for the appointment of depot-prover in the form of palliative or additional treatment are hormone-dependent forms of breast (breast) tumors in menopause in women, metastases or recurrences of endometrial cancer or kidney.

The initial dosage for kidney or endometrial cancer is 500 mg or 1 g per week. With the improvement (stabilization) of the condition for several months or weeks, a maintenance treatment of 500 mg per week is prescribed.

Therapy of cancer in the mammary gland is carried out for twenty-eight days. Dosage at the same time - 500 mg per day. At the end of this period, maintenance therapy is recommended. Dosage with this - twice a week for 500 mg. The drug is used until the reaction to the treatment is noted. In some cases, the results after the treatment of cancer in the breast (breast) can be observed eight or ten weeks after the start of the drug. In case of detection of rapid progression on the background of therapy of pathology, the drug is canceled.

Adverse reactions: urticaria, anaphylactoid conditions, rash, thrombophlebitis, thromboembolism, insomnia, nervousness, weakness, drowsiness, dizziness, depression, headaches, nausea. Also, patients can note changes in the nature of vaginal discharge, galactorrhea, sensitivity in the chest. Against the background of the use of the drug, it is possible to form the Itzenko-Cushing syndrome.

Contraindicated drug during pregnancy and hypersensitivity to the components.

Depo-Provera 150 is used as a contraceptive medication. In this case, one injection is used in three months. Depot-test specialists are described as one of the safest contraceptives. The drug is allowed for use by nursing mothers (after delivery from the sixth week). In the opinion of specialists, the advantages of injection contraceptives are many times greater than the probability of occurrence of adverse reactions.

It is also important that the full restoration of the childbearing function in a woman occurs within six to eighteen months after the withdrawal of the drug.

The drug is used not only as a contraceptive. It is effective in anemia, endometriosis, climacteric syndrome, uterine bleeding (dysfunctional).

Use of the drug "Depot-Provera" reduces the likelihood of developing fibro-cystic mastopathy, endometrial cancer , pathologies in pelvic organs of an infectious-inflammatory nature, uterine myomas.