The drug 'Claforan'. Instructions for use

Characterizing the drug "Claforan", patients' reviews indicate the high effectiveness of the drug. This drug refers to the antibiotic cephalosporin series in the third generation. The drug is available in the form of a powder (lyophilized) for the preparation of a solution for injection (intramuscular and intravenous). The active substance is cefotaxime.

The drug "Claforan" instructions for use characterizes as a semi-synthetic antibiotic with a bactericidal effect.

After one intravenous injection of the drug at a dosage of 1 gram, the concentration of the active ingredient is 100 μg / ml in the blood. After intramuscular injection of the same amount of drug, the Cmax of the active substance is observed after half an hour and is 20-30 μg / ml.

Cefotaxime is able to overcome the placental barrier.

The drug "Claforan" is recommended for use in infectious and inflammatory pathologies due to the activity of microorganisms that exhibit sensitivity. Such diseases include, in particular, bacteremia, septicemia. In addition, the agent is effective for infections in the genitourinary and respiratory system, central nervous system, soft tissues, joints, skin, bones, as well as with intra-abdominal infections (with peritonitis, including). The drug "Claforan" instruction for use recommends use as a prophylaxis for complications after interventions in the gastrointestinal tract, as well as after obstetric-gynecological and urological operations.

Dosage

In acute gonorrhea of uncomplicated nature, adults are prescribed an antibiotic intramuscularly once. The dosage is 0,5-1 g.

In cases of moderate complications of uncomplicated nature, the Claforan drug recommends that you insert 1-2 grams every eight or twelve hours into the muscle or vein. The total dose per day with this - 1-6 grams.

In the treatment of severe infections, the drug is administered in a dose of two grams at intervals of six to eight hours. The total amount of the drug per day is from six to eight grams.

The duration of therapy is determined by a specialist individually.

In the treatment of pathologies provoked by strains that are not sensitive to the drug, a test is performed that determines the sensitivity and allows one to evaluate the effectiveness of the antibiotic.

To prevent the occurrence of postoperative complications, before the intervention against the background of the initial anesthesia, the drug "Claforan" instruction for use recommends injecting intravenously or intramuscularly in a dosage of 1 gram. Repeated injection is performed six or twelve hours after the operation.

The drug is contraindicated in hypersensitivity to drugs cephalosporin series or lidocaine and other local anesthetics of the amide type. Medication is not prescribed for severe heart failure. Intramuscular administration is contraindicated in children up to two and a half years. For lidocaine-containing forms of the drug, intravenous administration is not used .

Due to the fact that the safety of using the drug "Claforan" during pregnancy in women is not established, the use of the drug in this period is contraindicated. If necessary, use the medication during lactation, breastfeeding is discontinued.

The drug "Claforan" can provoke bronchospasm, angioedema, extremely rare - anaphylactic shock. The negative effects of the drug include also erythema multiforme, skin redness, rash, dyspepsia, pseudomembranous colitis, arrhythmias, inflammatory processes in the area of administration, fever.

The drug "Claforan" is intended for use under the supervision of a doctor.