The drug 'Antistene'. Instructions for use

The drug "Antisten" (pills) is a very common remedy for violations in the cardiovascular system. As a rule, the medicine is included in the complex therapy. According to experts, the drug "Antistain" is an excellent supporting, auxiliary drug.

The active component of the drug is trimetazidine. Characterizing the actions of the drug "Anti-Sten", the instruction for use draws attention to the properties of the active substance. In particular, trimetazidine is able to directly affect cardiomyocytes and neurons of the brain, optimizing their function and metabolism. The cytoprotective effect of the drug is associated with an increase in the energy potential. This activates oxidative decarboxylation (cleavage of carboxylic acid molecules ) and rationalization of oxygen consumption.

The active component is able to maintain myocardial contractility, preventing a decrease in the intracellular concentration of ATP (adenosine triphosphate) and phosphocreatinine. Trimetazidine normalizes the activity of membrane ion channels, preventing the accumulation of sodium ions, calcium in cardiomyocytes, stabilizes the content of potassium ions inside the cell.

The active substance prevents the damaging effect of free radicals, ensures the integrity of the cell membranes, prevents the activation of neutrophils in the ischemic zones, increases the duration of the electrical potential.

The drug "Anti-Sten" reduces the incidence of angina attacks, reduces the need for nitrates. After two weeks from the beginning of treatment, there was an increase in tolerance to the load, a decrease in sharp fluctuations in blood pressure. There is also a decrease in noise in the ears, dizziness of ischemic nature. In the presence of vascular eye disease, the drug "Anti-Sten" helps restore the functional activity of the retina.

The drug is prescribed for IHD, as part of complex therapy to prevent the development of angina attacks. Medication "Antisten" instructions for use recommends for cochleovestibular disorders of an ischemic nature: hearing loss, noise in the ears, dizziness. Chorioretinal vascular lesions are also referred to indications.

The drug "Anti-Sten" instructions for use are not recommended for renal failure, expressed disorders of the liver, hypersensitivity to the drug, at the age of eighteen.

During animal studies, there was no teratogenic effect on the fetus or reproductive function. However, there are no clinical data on the safety of the use of "Antistain" in pregnant women. In this regard, the drug is contraindicated in the period of gestation.

The ability of the active ingredient to excrete in breast milk has not been clarified. When prescribing a medicine to a nursing woman, it is necessary to warn her about the need to stop breastfeeding.

The drug "Antistain" instruction for use recommends taking with meals. The duration of therapy is determined by the doctor. Dosage for adults - a pill twice a day.

Taking medication can cause some negative reactions. The most common side effects of the drug "Anti-Sten" instruction refers to vomiting, abdominal pain, diarrhea, nausea and other dyspeptic symptoms. In some cases, orthostatic hypotension, dizziness, tremor and other extrapyramidal disorders can occur, usually after the termination of therapy. There are also allergic reactions in the form of rash, itching or urticaria.

In the course of the studies, there was no significant effect of the drug on the ability to drive, concentrate attention, and exhibit a psychomotor reaction.

Before using the drug "Antistain" you need to consult a doctor and study the annotation.