"Menopur": instruction, price, reviews, description, doses

Why do I need the medicine "Menopur"? The instruction of the preparation, its methods of application and dosages will be described in this article. From it you will also learn about what indications there are for this medication, whether it has side effects and contraindications, what patients say about it, what its cost, etc.,

Composition, form of release of the medicinal product

In what form is the medicine "Menopur" sold? Instructions for use of the medication contain information that the preparation is available in the form of a lyophilizate, which is intended for the preparation of a solution for intravenous or subcutaneous injection.

The drug is a white or practical white briquette without any smell. Also, a colorless and transparent solvent is applied to it.

What does the medicine "Menopur" contain? The instruction says that the active substance of the medication is follicle-stimulating, as well as luteinizing hormones. It also includes auxiliary substances in the form of polysorbate 20, lactose monohydrate, sodium hydroxide and hydrochloric acid.

The solvent is a solution of sodium chloride (isotonic).

Packaging of the preparation

The drug is sold in 2 ml vials. Together with it comes the solvent (ampoule with 1 ml of substance). In one carton can be 5 or 10 sets.

Pharmacological action of the drug

What is the medicine "Menopur"? Instructions for use indicate that this drug is a means of a high degree of purification of human gonadotropin (menopause). It belongs to the group of menotoropines, and also contains LH and FSH in a ratio of 1 to 1. The medication is obtained from female urine in postmenopausal women.

In the fairer sex, this agent stimulates the proliferation of the endometrium, the maturation and growth of ovarian follicles, and also causes an increase in the level of estrogens in the blood.

As for the stronger sex, this drug leads to an increase in the concentration of testosterone. In addition, it stimulates spermatogenesis by affecting the cells of tubules (seminal).

Pharmacokinetics of the medicinal product

How long is the drug "Menopur" absorbed? The guideline states that the maximum concentration of FSH in the blood is reached approximately 7-24 hours after intramuscular injection. After that, its volume gradually decreases. The half-life of menotropins is 5-12 hours.

Indications for use of medicament

The instruction to the preparation "Menopur" says that it can be used not only for the representatives of the weak, but also for the representatives of the stronger sex.

So, let's consider the indications for use for women:

• For carrying out reproductive techniques (auxiliary) for the purpose of onset of conception (that is, to stimulate the growth of follicles);
• For the treatment of infertility, which is due to hypothalamic-pituitary disorders (to stimulate the growth of the 1st dominant follicle).

For what purposes do men prescribe the medicine "Menopur"? Instruction, reviews, application will be presented further. As for the testimony, they include the following:

• To stimulate spermatogenesis (it is recommended to combine with human chorionic gonadotropin medicines).

Are there any contraindications to the medication?

When can not prescribe the drug "Menopur" (lyophilizate)? Instructions for use include the following contraindications:

• Tumor of the hypothalamic-pituitary region;
• Abnormal development of genital organs, as well as the presence of uterine fibroids, which is incompatible with pregnancy;
• Adrenal and thyroid gland diseases;
• Hyperprolactinemia;
• Ovarian enlargement (persistent), the occurrence of cysts (if the disease is not associated with polycystic ovary syndrome);
• Cancer of the ovaries, uterus or mammary glands;
• Bleeding vaginal unclear origin;
• Primary failure of the ovaries;
• Time of pregnancy;
• Cancer of the prostate gland, as well as other tumors (androgen-dependent) in the stronger sex;
• Lactation time;
• Sensitivity (increased) to menotropins, as well as medications that contain FSH or LH.

Medicinal preparation "Menopur": instructions for use, summary

The description of this medicine was presented above. With regard to this section of the article, in it we will tell you about the dosage in which the drug should be taken.

The drug is administered intramuscularly. Injection solution is prepared only before use, using the solvent that is included in the kit.

In the event that the attending physician has not been prescribed other therapy, it is recommended to adhere to the following scheme.

Women

For the treatment of infertility, which is due to the presence of problems with the hypothalamic-pituitary region, in order to stimulate the growth of the first dominant follicle, the dose of the drug is set individually. The optimal volume of the drug, as well as the duration of therapy are selected based on the performed ovaries, clinical observation and estrogen level. By the way, it is on the last value judge the maturation of the follicle.

So how should you use the medicine "Menopur"? The method of administration and dose of the drug are always indicated in the attached instructions. The initial volume of the drug can be 75-150 IU (or 1-2 vials a day).

If there are no ovarian reactions, then the amount of the drug is gradually increased to the growth of follicles and an increase in the level of estrogens. This dose is left unchanged until the moment when the concentration in the blood of the latter reaches the preovulatory value. With a sharp increase in the level of estrogens at the beginning of stimulation, the dosage of the agent should be reduced.

After the last injection after 2 days, 5-10 thousand IU hCG are injected once. Do this with the aim of inducing ovulation.

Men

How should the representatives of the stronger sex use the drug "Menopur"? The instruction says that for the stimulation of spermatogenesis, men need to administer 1-3 thousand IU hCG three times a week. Do this until the testosterone level is normal . After that, for several months three times a week, the medication is administered at 75-150 IU (or 1-2 vials).

Side effects of the drug use field

Now you know in what volume the medicine "Menopur" should be administered. Instructions, application, reviews are presented in this article. However, I want to note that this drug can cause a number of side effects.

• Endocrine system: increase (sharp) excretion of estrogens together with urine, mastalgia, formation of ovarian cysts, moderately pronounced ovary enlargement, gynecomastia (in representatives of the stronger sex).
• The digestive tract: vomiting, colicky pain, nausea.
• Local reactions: redness, swelling, and also itching at the site of administration.
• Allergy: skin rash, fever, arthralgia, the formation of antibodies, which leads to a decrease in the effectiveness of the treatment.
• Others: oliguria, weight gain, lowering of pressure, multiple pregnancies.

It should also be noted that the use of the drug in question can cause the appearance of the ovarian hyperstimulation syndrome. Early signs of such a deviation include pain (expressed) at the bottom of the abdomen, vomiting, ascites, weight gain, nausea, hypovolemia, electrolyte imbalance, hydrothorax, increased erythrocyte count, hemoperitoneum and thromboembolic syndrome.

Special instructions for using the product

What do you need to know before using the drug "Menopur"? The instruction, the reviews say that before the appointment of this medication the patient needs to undergo appropriate treatment (if there is a deficiency of the adrenal cortex, concomitant hypothyroidism, a hypothalamic-pituitary region tumor, hyperprolactinaemia).

Before the induction of infertility therapy, it is required to assess the condition of the ovaries. To do this, perform an ultrasound, and also check the level of estradiol in the blood. During the course of the course, these studies should be performed every other day or every day.

It should be borne in mind that against the background of using hMG funds, there is a possibility of developing ovarian hyperstimulation. As a rule, it becomes clinically pronounced only after the administration of the drug for the purpose of ovulation and manifests itself in the form of the formation of large cysts. In such cases, patients may experience hydrothorax, ascites, thromboembolic syndrome, and arterial hypotension.

When the first symptoms of ovarian hyperstimulation appear, therapy with the drug should be stopped immediately.

When treated with hMG, very often a multiple pregnancy is formed.

In representatives of the stronger sex with a high level of FSH in the blood, this medication is ineffective.

What is the cost of the drug?

How much is the drug "Menopur"? The instruction, the price of this tool are presented in this article. The cost of this medication is very high. For 1 vial of the drug you will have to give about 1000-1400 Russian rubles. Given the average course of treatment in 5-10 days, such therapy costs the patient very expensive.

Reviews about the drug

There is a huge amount of positive feedback about the medicine "Menopur". According to them, this drug treats well of infertility, several times increasing the likelihood of conception. By the way, a large number of patients after the use of this drug develops a multiple pregnancy.

The only drawback of the medicine in question is its cost. Most patients can not afford such a drug. Although pharmacists claim that the price of this medication is fully justified. After all, after its correct use, there is a huge probability of long-awaited conception and, consequently, the birth of a long-awaited child. Therefore, most young couples who can not conceive a baby, without any hesitation, acquire this remedy.