"Gliclazide": analogues, indications, instructions for use

One of the most common pathologies of the endocrine nature is diabetes mellitus. Most patients with this diagnosis suffer from a second type of this disease. The ailment requires constant treatment and medication. Stimulate the production of insulin in the body is able to drug "Gliclazide". Analogues can have a similar mechanism of therapeutic action or the same composition. Select the substitute for the original medicine should be the attending physician.

Description of the drug "Gliclazide"

The drug "Glycolyazid" refers to the derivatives of sulfonylureas (second generation) and has a pronounced hypoglycemic effect. The drug can be used in the treatment of insulin-independent diabetes. The main goal of therapy with "Glycolyazide" is to reduce the level of glucose in the blood. Also carbohydrate and lipid metabolism is normalized . In the pharmacy you can buy the medicine under the name "Gliklazid-Akos", "Glidiab-MB".

The same active substance positively affects the condition of the vessels, restoring their permeability and preventing the development of atherosclerosis. Long-term use of the drug in diabetic nephropathy provides a significant reduction in proteinuria (the presence of protein in the urine). Against the background of treatment, the agent significantly reduces the risk of developing a parietal thrombosis.

The maximum concentration of the main active substance in the blood is fixed in 6-12 hours after taking the tablets "Gliclazide". Analogues of the drug are also well proven, but they should be selected by a doctor individually. As part of the original preparation, the active substance is glycazide with a modified release.

Indication for appointment

According to the annotation, "Gliclazide" is prescribed to persons who have a history of diabetes (sugar) type 2. Pathology differs from the first type in that in the second case the independent production of insulin by the body completely ceases. The main cause of development of the disease is aging aging. However, the presence of extra pounds and excessive consumption of carbohydrates can also trigger the development of diabetes.

Tablets "Gliklazid" instruction recommends the use of complex therapy for violations of microcirculation. For preventive purposes, the drug is prescribed to prevent the development of severe consequences of diabetes: stroke, heart attack, nephropathy, retinopathy.

Contraindications

It is forbidden to take "Gliclazide" (analogues of the drug, including) in the presence of the following diagnoses:

• Intestinal obstruction;
• Leukopenia;
• A severe stage of renal and hepatic insufficiency;
• Diabetes mellitus (type 1);
• Infectious diseases, in which there is a violation of the process of food intake;
• Paresis of the stomach;
• Lactation period;
• Age to 18 years;
• Ketoacidosis;
• Pathological conditions in which the use of insulin is required;
• pregnancy.

How to take "Gliclazide"?

Dosage of a hypoglycemic agent is selected by a specialist individually. The daily dose can vary between 30-120 mg of active ingredient, depending on the severity of the patient's condition and age. Take the pill once a day before meals (preferably on an empty stomach).

If you miss taking medication, it is not recommended to increase the dosage. In some cases, the maximum dosage may be up to 320 mg.

Features of the drug "Gliclazide"

Analogues of a hypoglycemic agent, like the original preparation itself, are used only in combination with a low-calorie diet, which implies the use of a minimum amount of carbohydrates. It is important to monitor the level of glucose in the blood serum before and after eating. Correct the dosage of the drug after emotional overstrain or physical exertion.

Drug remedy can be canceled with a fever caused by extensive burns, surgical interventions. With the simultaneous administration of "Gliclazide" and ethanol-containing medications, non-steroidal anti-inflammatory drugs, there is a risk of developing hypoglycemia. Ethanol can cause abdominal pain, vomiting, bouts of nausea.

Analogues

Drugs of sulfonylurea are considered to be the main drugs in the treatment of diabetes. To their essential disadvantages is the development of resistance. A similar situation occurs in 5% of patients who are subsequently transferred to insulin therapy.

The drug "Gliclazide", the price of which ranges from 130-160 rubles per package (30 tablets), can be replaced with a drug with a similar composition. On the basis of gliclazide, they also produce modified release medicines. The following analogues of the original medicine are considered effective:

• Glydiab.
• "Diabetes MB."
• "Vero-Gliklazid."
• "The Diatics".
• "Diabetolong."
• "Diabinax."
• "Glidiab MB".
• "Diabetes".

Preparations based on gliclazide have a positive effect on microcirculation, haematological parameters, hemostasis system. This is extremely important for patients with type 2 diabetes mellitus. Selecting medicines to stimulate the production of insulin should be the attending physician. It should be borne in mind that such a therapeutic effect entails an increase in body weight.

Diabetes Pharma: instructions for use

The hypoglycemic agent is available in tablet form. One tablet contains 80 mg of the main active substance gliclazide. As auxiliary components used milk sugar, magnesium stearate, povidone. The manufacturer - the Russian pharmaceutical company - produces the drug Diabefarm MV with a modified release. In these tablets, the dosage of the active ingredient is reduced to 30 mg. Release occurs within 24 hours.

The dose of the drug is selected individually. The doctor takes into account the level of glucose in the blood serum, the age of the patient and the symptomatology of the disease. The initial daily dose should not exceed 80 mg. Later it is increased to 160-320 mg of glycazide.

"Diabetes" instructions for use recommend appointing adults who are not effective diet and exercise. Modified-release tablets (CF) should be taken once a day. The doctor can increase the dosage after conducting blood tests for sugar.

Side effects and overdose

Specialists note that side effects on the background of taking the medication develop mainly with non-compliance with dosing and general recommendations for comprehensive treatment. Hypoglycemia - one of the frequent side effects - is accompanied by symptoms such as increased appetite, arrhythmia, palpitations, fatigue, drowsiness.

From the side of the digestive tract, the following disorders may occur:

• Constipation;
• Vomiting;
• nausea;
• hepatitis;
• diarrhea;
• Holistatic jaundice.

In rare cases, allergic reactions occur in the form of itching, hives, redness of the skin. Some signs of a side effect of the drug require its cancellation.

Overdosing often leads to the development of hypoglycemia, hypoglycemic coma, impaired consciousness. Restore the concentration of glucose can be by intravenous injection of dextrose (if the patient is unconscious). In the event that there are clear signs of hypoglycemia, but the patient remains conscious, he needs to take a small amount of sugar.

The drug "Glidiab"

Another hypoglycaemic agent with a pronounced therapeutic effect is Glioadab. Instructions for use indicate that one tablet contains 80 mg of the active substance gliclazide. One package contains 60 tablets. The cost of the drug is 110-140 rubles. "Glydiab MB", the price of which is 140-170 rubles, are assigned to patients more often.

The action of the drug is based on the activation of cells in the pancreas that produce insulin. "Glydiab" is able to restore the first peak of insulin secretion, which distinguishes it from some other drugs from the group of sulfonylurea derivatives.

After 4 hours after taking the medication, the maximum concentration of glycazide in serum is observed. Absorbed in the gastrointestinal tract almost completely.

Interaction with other medicines

"Glidiab" instruction manual Recommends taking with caution with simultaneous therapy with glucocorticoids, calcium antagonists, barbiturates, lithium salts. This will cause a decrease in the therapeutic efficacy of the hypoglycemic agent.

An increase in the activity of the active substance will be observed in the case of a combination of Glydiab with antifungal oral medications, fibrates, indirect anticoagulants, other hypoglycemic agents, anabolic steroids. Before starting therapy, the doctor should inform the patient about the features of taking the drug.

"Diabetes MB"

The agent "Diabeton" with modified release of the active substance belongs to the group of sulfonylurea derivatives of the second generation. A distinctive feature is the presence of a heterocyclic N-containing ring, which has an endocyclic bond. Specialists note that when taking medication for 2 years, resistance does not develop.

The drug is intended solely for the treatment of adult patients, as is the original preparation "Gliclazide." The price of the French medicine is 320-370 rubles per packing (30 pieces).

The maximum concentration of glycazide in the blood is observed 6-12 hours after taking the tablet. This allows you to reduce the number of medications per day. Usually doctors recommend taking 1-2 tablets a day. Specialists and patients leave extremely positive feedback about the treatment with this drug.

Patients should note that the drug includes lactose. Therefore, it is not recommended to take it with congenital intolerance to this substance or galactoseemia.

According to the reviews, "Diabeton MB" is considered one of the most effective means of the sulfonylurea derivatives. A significant advantage is the rare occurrence of side effects when taking medication. The only way to determine the dosage and the regimen of treatment is by a specialist. The patient must be examined beforehand. It is highly undesirable to take medication independently to reduce glucose levels.