"Biprol": indications for use, instructions for use, reviews, analogues. What helps Biprol?

Cardiovascular diseases occupy a leading position among other diseases. They suffer thousands of Russians. This is what helps Biprol. It prevents the development of the disease, relieves heart attacks and is affordable.

Form of issue and composition

Diseases of the heart and blood vessels - that's what helps Biprol. The drug is produced in coated tablets. Active substance is bisoprolol fumarate in a dose of 5 and 10 mg.

As additional ingredients are: cornstarch, microcrystalline cellulose, aerosil, crospovidone, ludipress and magnesium stearate. The shell contains polyethylene glycol, hypromellose, talc, titanium dioxide, tropeoline O.

In a cardboard box there are 30 or 50 tablets.

Pharmacological properties

The drug belongs to selective beta1-adrenoblockers, does not have internal sympathomimetic activity and is not endowed with membrane-stabilizing properties.

Bisoprolol fumarate reduces the manifestation of plasma renin, reduces myocardial oxygen needs, and heart rate both at rest and during exercise. Has antihypertensive, antiarrhythmic and antianginal properties. In low concentrations, it counteracts β1-adrenoreceptors of the cardiac apparatus, reduces the catecholamine-activated formation of cAMP from ATP and the current of calcium ions inside the cells. Used in large doses, it exhibits beta2-adrenoblocking properties.

The general peripheral vascular resistance at the very beginning of the use of tablets, especially in the first day, increases, but after 1-3 days comes to the initial state, and with prolonged use - decreases.

The hypotensive property determines a decrease in the minute amount of blood, autonomic activation of peripheral vessels, reduces the activity of the renin-angiotensin-aldosterone complex. It is characterized by the reconstruction of the susceptibility to lowering blood pressure and affecting the central nervous system. With an increase in blood pressure, the primary result is observed on days 2-5, and the condition stabilizes after 30-60 days.

The antianginal property is manifested in the reduction of myocardial oxygen demand due to a decrease in the heart rate and muscle contractility, diastole increase and progression in myocardial perfusion, as well as an increase in the diastolic left ventricular pressure and the elasticity of the muscles of both ventricles.

Antiarrhythmic characteristics associated with the removal of arrhythmogenic causes, an increase in the number of cAMP, a decrease in excitation of sinus and ectopic pacemakers and inhibition of AV-conduction.

The use of the drug in average therapeutic doses does not have such a strong effect on organs with β2-adrenoreceptors. The drug in this amount does not affect the carbohydrate metabolism and does not stop the release of sodium ions from the body. High doses of the drug inhibit the subtypes of β-adrenergic receptors.

The above described characteristics of the properties of bisoprolol fumarate show in detail what helps Biprol.

Pharmacokinetics

The medicine "Biprol" dissolves in the gastrointestinal tract by 80-90%. Its absorption is not affected by eating. The greatest concentration of active substance in the blood is observed after 1-3 hours. The connection with blood proteins occurs by 30%. In small quantities, the active substance penetrates the blood-brain and placental barrier, a small part is excreted in the mother's breast milk.

Metabolised in the liver. The half-life is 10-12 hours. Half of the active substance goes unchanged in the urine, and 2% - with bile.

What helps Biprol

The drug is prescribed for arterial hypertension. In hypertensive disease, a steady increase in blood pressure is observed. "Biprol" indications for use also has with coronary heart disease, where it is most often used for preventive purposes in angina attacks.

Contraindications

It is necessary to take the drug "Biprol" strictly according to the prescription of the doctor. Indications for its use are described above, and now about contraindications. These include shock of various genesis, including cardiogenic. You can not drink tablets in case of collapse and swelling of the lungs. The prohibition is acute and chronic heart failure, and also II-III stages of AV blockade development. Contraindication is the diagnosis of weakness syndrome sinus node, cardiomegaly, bradycardia, hypotension arterial and angina Prinzmetal. Do not prescribe the drug for asthma bronchopulmonary apparatus, obstructive pulmonary disease in chronic form and with the intake of MAO inhibitors. You can not use it for patients with peripheral circulatory diseases, with pheochromocytoma, when there is metabolic acidosis, to persons under eighteen years old. It is forbidden to patients with hypersensitivity to the active substance and other components of the medicine.

With caution, prescribe "Biprol" to patients suffering from liver failure, as well as people with chronic renal failure in chronic form, patients with myasthenia and thyrotoxicosis. Caution should be exercised by individuals with diabetes mellitus, I degree of AV blockade and patients with depression. Only in special cases it is prescribed for psoriasis and patients of retirement age.

Instructions for use

It should be taken into account when using the drug "Biprol" indications for use. Tablets are taken on an empty stomach in the morning. They are not chewed and washed down with water.

The drug is consumed 5 ml once a day. If necessary, the dosage is increased to 10 mg, which is drunk once a day. A day can take a maximum of 20 mg.

For people with impaired renal function, as well as for patients with liver disease, the maximum dose is 10 mg per day.

Special conditions

Continuous medical supervision of patients using Biprol should be performed. What helps the medicine, it was described above, and now how to monitor the condition of the patient who drinks these pills. First of all, measurements of heart rate and pressure should be carried out, these indicators are very important at the very beginning of therapy. Patients are made an electrocardiogram, and people with diabetes take a blood test for glucose. Older people monitor the state of the kidney system.

The work of external respiration in patients with pulmonary diseases in history is under examination.

Patients should learn to count the frequency of their own heartbeats, and if the indicator is less than 50 beats per minute, then you should seek medical help.

In the process of therapy, the development of tear fluid may decrease, which should be taken into account by the owners of contact lenses. In people with diabetes, the drug can hide a tachycardia, provoked by hypoglycemia. The drug does not increase the hypoglycemia that occurs when insulin is used and does not inhibit the recovery of glucose concentration to normal levels in the blood.

Before the operation, the drug is canceled two days before the general anesthesia. If the patient still uses the pill before surgery, then the drug for anesthesia should have a minimum negative inotropic property.

People with bronchospastic diseases are prescribed cardioselective adrenoblockers when it is not appropriate to use other antihypertensive drugs. Overdose can provoke bronchospasm.

In elderly people with bradycardia and with a clear decrease in blood pressure, AV blockade, the concentration of the active ingredient should be reduced or completely discontinued with Biprol therapy. Stop treatment is also necessary if the patient has a depressive condition.

Do not stop therapy if there is a danger of progression of arrhythmia in severe form and myocardial infarction. The refusal to use the medication is carried out gradually, reducing the norm for 14 days. Tablets are canceled beforehand if laboratory tests of urine and blood are scheduled for the presence of normetanephrine, catecholamines, etc.

Side effects

It is necessary to use only under the prescription of the doctor the drug "Biprol". The use of tablets in doses exceeding the recommended levels, as well as in diseases where the use of this drug is prohibited, leads to the occurrence of side effects.

With prolonged therapy, fatigue, headache, weakness, sleep disturbance, depression, confusion of thoughts, hallucinations, anxiety, tremor, asthenia and myasthenia gravis occur. In patients, there is a disturbance of the visual apparatus, expressed in the reduction of tear fluid, excessive dryness of the eyes and their soreness. There is a conjunctivitis.

In the treatment of patients seen: sinus bradycardia, excessive palpitations and malfunctions in the conductivity of the myocardium, as well as AV-blockade, arrhythmia, aggravation of the condition of the patient suffering from heart failure in chronic form. Sometimes there is a weakening of myocardial contractility and lowering of arterial pressure, hypotension in orthostatic form, pain in the sternum, withdrawal syndrome, which was accompanied by stronger attacks of angina and an increase in the index of blood pressure.

Excessive dry mouth, diarrhea, nausea, abdominal pain, constipation, etc. were observed. In some cases, nasal congestion and difficulty breathing were recorded. Sometimes patients were allergic to rash, itching and urticaria. There was excessive sweating, hyperemia of the epidermis, exanthema, psoriasis.

Overdose

It is strongly recommended that the prescribed dosage be prescribed when administering Biprol. Reviews say that this drug is worthy of attention. It is effective and inexpensive, but if you use a dose that is higher than what is prescribed, you may experience overdose symptoms. They are expressed in the form of arrhythmia, extrasystole of ventricular nature, obvious bradycardia. Overdose can cause AV blockade, a marked decrease in blood pressure, heart failure, cyanosis of the nail plate, bronchospasm, convulsions, dizziness, difficulty breathing.

When an overdose is done rinsing the stomach and prescribing adsorbents. Conduct symptomatic treatment. If an AV blockade occurs, 1-2 mg of atropine, which can be replaced by epinephrine or a temporary pacemaker, is done. At a lowered arterial pressure, the person is placed in the Trendelenburg position and plasma-substituting solutions are injected intravenously. With heart failure recommend diuretics, glycosides or glucagon. When convulsions are administered "Diazepam", bronchospasm is removed by inhalation.

Storage conditions and shelf life

It advises not to apply after the expiry date of the drug "Biprol" instructions for use. Analogues are available at a price and they can be found at any pharmacy.

Shelf life of the medicine is three years from the date of manufacture. The drug should be stored in a cool dark place inaccessible to children at a temperature of no higher than +25 ° C.

Biprol: analogues

If the drug for some reason does not fit the body, then instead you can find a drug with similar properties. Replace "Biprol" (analogues are similar to it for the active component and action) can only after consulting a doctor with the following medications: Tyrise, Aritel, Niperten, Bidop, Coronal, Bisogamma, Cordinorm "," Bisoprol "," Concor ". The difference between the means is only in the price and the producer.

Cost

The price of the medicine is about 150 rubles for 30 tablets of 10 mg each. Dragee with 5 mg costs about 80 rubles for 30 pieces.

Patient Reviews

Almost in all situations can replace "Biprol" analogs. Reviews about this drug are mostly positive. Some people have chosen to replace the original, since it has many side effects. Those people who still decided to take "Biprol", well tolerated the medicine. They noted its high efficiency and good results. There are patients who replaced them with imported "Concor".

Experts about the medicine respond well. It is said that he takes off angina attacks and rarely causes side effects. Basically, this is a headache.

"Biprol" is one of the most popular and effective means. With the right appointment and strict observance of all prescriptions of the doctor, it gives a lasting and lasting effect.