"Berlion" - analogs. "Dialipon": instructions, reviews of doctors

Disturbance of body metabolism is a very common disease. A huge number of diseases is accompanied by the development of metabolic syndrome. One of these diseases is diabetes mellitus. The main therapy of this pathological condition is aimed at reducing the occurring metabolic disorders and a qualitative increase in the functional state of the nervous system. A highly effective drug that is used to treat such disorders is the drug "Berlition" and its analogue "Dialipon".

Let's look at how the main component of these drugs works: lipoic acid, its application in various situations.

Pharmacodynamic features

The main active ingredient in the preparation "Berlion", analogues of this drug, alpha-lipoic acid, is a coenzyme synthesized by virtually all cells of our body. The main function of this enzyme is the oxidative decarboxylation of alpha-keto acids, which determines its active role in maintaining the energy balance of the cell. Taking active part in metabolic reactions of cells, lipoic acid promotes optimal reduction of blood sugar level (due to increased utilization of this energy substrate), as well as enhancement of glycogen synthesis in hepatocytes. Since this coenzyme takes an active part in the reactions of the tricarboxylic acid cycle, its lack (for example, associated with an increase in the level of ketones) leads to a decrease in the intensity of the processes of aerobic decay of glucose.

Due to pharmacological similarity with the preparations of vitamins of group B, lipoic acid is able not only to exert antitoxic and antioxidant effects, but also to influence the exchange of cholesterol in the body, lipid metabolism and to provide hepatoprotective action. The latter effects are due to the ability of the drug to affect the so-called SH-groups of proteins.

Pharmacological characteristics

After entering the body, lipoic acid undergoes significant changes due to primary metabolism in hepatocytes. The structure changes mainly due to the oxidation of the side chains and the formation of conjugates. Systemic availability varies in different groups of patients, which is due to the individual characteristics of the organism and the effect of the disease. Excretion of lipoic acid and its metabolites is carried out mainly by the kidneys, but also partially the drug is secreted with bile. The half-life of plasma from the blood ranges from 10 to 20 minutes.

Lipoic acid: use

Lipoic acid is indicated for use in patients with diabetes mellitus to improve sensitivity in developing diabetic polyneuropathy. There are data on the effectiveness of thioctic acid in the complex treatment of atherosclerosis of the coronary arteries and diseases of the hepato-biliary system. The drug is also effective in treating poisoning with salts of heavy metals (due to the ability to restore SH-groups).

Contraindications for use

For lipoic acid, "Berlion" or its analogue, the preparation "Dialipon", the instruction for use informs that they are contraindicated in case of hypersensitivity to the components, with acute cardiac and respiratory insufficiency. Also they are forbidden to take with chronic alcoholism and violation of cerebral hemodynamics, during lactation.

"Berlition" and "Dialipon": instructions for use

Preparations are administered intravenously, from the bottle, without prior dilution. The daily dosage of these medicines for adults is 600 mg. Dropper "Berlion" or "Dialipon" is put and drips for at least half an hour. The approximate course of treatment is two to four weeks. If necessary, continue taking the drug can be in the form of capsules in a similar dosage.

Tablets "Berlition" are used for adults at the rate of 25-50 mg two or three times a day, for children, dosage of 12 or 24 mg is possible.

Side effects

Side effects arising from the nervous system and analyzers, manifested in the form of double vision, a violation of taste. Low probability is the appearance of a convulsive syndrome. In this case, the latter occurs in the form of small attacks or the type of absences.

On the part of the blood system, hemorrhagic eruptions may appear as a thrombocytopenic purpura, thrombosis in the veins of the lower limbs.

Allergic reactions to the administration of the drug are manifested in the form of redness, eczema at the injection site. Perhaps the development of allergic reactions at the organism level, proceeding according to the type of anaphylactic shock.

On the part of the whole organism, it is possible to reduce the level of glucose in the blood plasma, violations from the vestibular analyzer, headaches and dizziness.

Patients who receive injections for the first time need to be informed that there may be contracting pain in the head and heart area that are self-healing and do not require additional therapy.

Do not think that the manufacturer and the name determine the frequency of adverse reactions. "Berlion", analogs of this drug are equally capable of causing side effects depending on the characteristics of the body and the course of the disease.

Special instructions for the use of the drug

In view of the high instability of the drug under exposure to sunlight, it is recommended to cover the vials with the drug with a black opaque material or a cover. In the conditions of separation, it is convenient to use special light-protective covers.

In view of the hypoglycemic effect occurring after the administration of the drug, special attention should be paid to monitoring the glucose level in the blood plasma of patients with diabetes mellitus.

In the process of treatment with the drug "Dialipon" it is necessary to refrain from drinking alcohol, as this can lead to a decrease in the therapeutic effectiveness of this drug.

It must be remembered that the drug interacts with sugars and metal ions, so it is counter-indicative to combine alpha-lipoic acid with solutions of Ringer, glucose, fructose. Also, the drug can not be shared with drugs containing magnesium and iron ions.

"Dialipon" is not used in the period of breastfeeding and lactation. Due to the lack of data on the effectiveness of this drug in children, the use of the latter is contraindicated.

Data on the effect of the drug on the reaction rate and the ability to control the mechanisms there.

Drug Interactions

Lipoic acid enhances the therapeutic effect of insulin and hypoglycemic drugs. This should be taken into account in patients with diabetes mellitus.

Overdose

Symptoms of overdose are nausea, dizziness and headaches, vomiting, psychomotor agitation up to the development of generalized convulsive syndrome. In the case of taking high doses of the drug, it is possible to develop such conditions as hypoglycemic shock, necrosis of the striated skeletal muscle, oppression of the central nervous system and disruption of the internal organs until the development of multiple organ failure.

Therapy for poisoning is symptomatic, based on the rules of emergency medical care. There is no specific antidote. The effectiveness of dialysis methods has not been proven.

Reviews of doctors

Due to the high effectiveness of the drug, doctors recommend it for use, especially when treating complications of diabetes. In turn, patients taking the "Berlion", the analogues of this drug, do not note a special difference in the effectiveness of the action between them.

Depending on the mark-up, the cost of this type of preparations may differ materially. On average, from 650 to 950 rubles is the drug "Berlition" (analogs). The price depends on the dosage (smaller dose - less cost), and also from the manufacturer.

Conclusion

The drug "Berlion", analogues in the form of "Dialipon" or "Dialipona Turbo" are effective drugs in the fight against complications of diabetes in patients of different age groups. Due to its high therapeutic efficacy, alpha-lipoic acid can also be used for the symptomatic treatment of alcoholism.