What is 5-alpha reductase? Preparations - enzyme inhibitors

All processes in the body occur with the participation of biologically active substances, in particular enzymes. It is to this group that the protein substance of 5-alpha-reductase belongs. Unfortunately, in some cases, a failure occurs in the synthesis of active substances, which leads to failures in the work of the whole organism. So what is this enzyme and in what cases do doctors use inhibitors of 5-alpha-reductase? What are the possible consequences of therapy? Are there any contraindications? Many of the readers are interested in answers to these questions.

5-alpha-reductase: what is it?

To begin with it is necessary to understand the basic functions of a substance. 5-alpha-reductase is a protein compound, the enzyme of which takes part in the processes of steroidogenesis. This substance stimulates the conversion of testosterone (male sex hormone) to dihydrotestosterone, which is more intense. In addition, the enzyme promotes the formation of allopregnanolone and some other neurosteroids.

5-alpha-reductase is produced mainly in the organs of the reproductive system, in particular in the tissues of the prostate and seminal vesicles. A small amount of the enzyme is also formed in skin cells, hair follicles and some parts of the nervous system.

Why do we need inhibitors?

5-alpha-reductase inhibitors are drugs that block the production of this enzyme and affect the amount of male sex hormones in the body. Today, these drugs are widely used. For example, they are often prescribed to patients suffering from acne. Preparations of this group help prevent alopecia (baldness).

There are many areas of use of drugs that inhibit the production of an enzyme such as 5-alpha-reductase. DGT blockers (dihydrotestosterone) are used to treat prostatic hypertrophy. Proper medication helps to reduce the volume of the prostate in inflammation.

The effectiveness of the therapy has been confirmed by numerous scientific studies conducted in laboratories with a worldwide reputation.

5-Alpha-Reducase inhibitors: synthetic preparations

To date, in the manufacture of drugs in this group, two main active components are used:

1. Dutasteride is a selective inhibitor and is widely used to treat benign prostatic hyperplasia. The most popular is Avodart.

2. Finasteride - a synthetic substance that causes a decrease in the level of enzymes, not only in the blood, but also directly in the tissues of the prostate. The effect lasts about 24 hours. Sometimes it is even used in the therapy of prostate cancer, although its 100% efficacy has not been proven. The choice of preparations in which finasteride is present is much larger: Alfinal, Urofin, Finast, Proscar, Zerlon, Penester and others.

Herbal medicines

Of course, synthetic drugs can provide a more pronounced effect. But quite often used drugs on a plant basis - they affect the body softer and almost harmless. By the way, such drugs are used not only for diseases of the prostate gland. They help fight against alopecia (including female alopecia) and acne.

To treat hyperplastic processes in the prostate, fruits of dwarf palm are widely used, which are rich in phytosterols and fatty acids. Isoflavones are another group of substances that have antiandrogenic properties. By the way, similar properties have and nettle dioecious. Herb plants are widely used to strengthen hair.

Are there any side effects?

It is necessary to take with caution the blockers-preparations of 5-alpha-reductase, especially if it is a question of synthetic agents. The fact is that these drugs act directly on the patient's hormonal background.

With long-term admission, many patients note changes in sexual activity. In particular, there is a violation of potency and a decrease in sexual desire. Sexual contacts are often accompanied by problems: a dull erection, a brief sexual intercourse, etc. Side effects include reducing the volume of ejaculate. Because of the decrease in the number of neurosteroids, patients develop depression, although this side effect is extremely rare.

Therapy must be carried out under the supervision of a doctor. If we are talking about preparations of plant origin, then the body quickly gets used to them, so the effect of the medicine is gradually reduced to a minimum. On the other hand, phytopreparations are relatively safe for health.

Contraindications to the use of inhibitors

Not in all cases, you can take drugs that inhibit the activity of the enzyme called "5-alpha-reductase." These drugs are not prescribed to patients with acute inflammatory diseases, including prostatitis.

Before drawing up the scheme of therapy it is necessary to undergo a complete diagnosis of the organism. If a suspected oncology is suspected, prostate biopsy is performed. The presence of malignant neoplasms is a contraindication to the use of the drug. Also, the drug is not prescribed to patients during the post-operation period and in the presence of kidney failure.