"Cordynik": instructions for use, analogues and reviews

Antianginal drugs are called drugs that increase the flow of blood to the heart, as well as reduce its need for oxygen. Such medications are very often used to stop or prevent attacks of angina pectoris.

Angina pectoris is a disease characterized by painful sensations or a feeling of discomfort behind the sternum. Typically, the pain with such a disease manifests suddenly in emotional stress or physical exertion, as well as after eating. Usually, it gives to the neck, left shoulder, between the scapula, the lower jaw and the left sub-flap area. Such discomfort disappears in ¼ hours. Also, the pain disappears after stopping physical exertion or after taking an antianginal drug. As the last very often used medicament "Cordynyk." The instructions for use, the description of the preparation and its properties are presented below.

Description of the medicinal product, its form, composition and packaging

What form is inherent in the Cordynik medicine? Instructions for use indicate that this drug can be purchased in the form of tablets. They have a flat-cylindrical shape, have a white or weak grayish-yellowish color.

The composition of the drug in question is nicorandil. As auxiliary components, potato starch, calcium stearate and microcrystalline cellulose are used.

In the sale of medicines "Cordynyk", the instruction for use of which is packed in a pack of cardboard, enters the contour cells.

Pharmacology of a medicinal product

What is remarkable about the medication "Cordynic" (pills)? Instructions for use indicate that nicorandil has an antianginal effect. It is based on a combination of nitrate-like properties, as well as the ability to open potassium channels. Due to the latter property, this preparation causes hyperpolarization of the cell membrane.

The nitrate-like effect of this drug is to increase the content of cyclic guanylmonophosphate inside the cells. Such pharmacological effects contribute to the relaxation of smooth muscle muscles, as well as the protection of the myocardium in ischemia.

With regard to hemodynamic effects, they are expressed in a balanced decrease in post-preload. Given the vasodilation (selective) coronary arteries, the burden on the ischemic myocardium is minimized.

Nicorandil does not affect the contractility of the myocardium. In addition, this substance does not change the heart rate. However, it reduces systemic blood pressure, and also has a beneficial effect on the blood circulation of the brain in people with ischemic stroke.

What other properties are inherent in the drug Cordynic? Instructions for use (analogues of the drug are listed below) states that nicorandil does not have any effect on glucose metabolism and lipid metabolism. It stops the attack of angina, and also reduces the pain syndrome within seven minutes after receiving under the tongue. Complete elimination of discomfort is observed after ¼ hours.

Kinetics of the agent

Where does the Cordynik drug come from? Instructions for use indicate that the absorption of the drug in question occurs from the gastrointestinal tract. It reaches its peak concentration in plasma after 35-60 minutes.

Nicorandil only slightly binds to plasma proteins. Its free fraction in the blood is 75%.

This medication is not subjected to intensive metabolism in the liver. It is excreted by the kidneys for 50 minutes.

Indications for admission

When should I take Cordini tablets? The instruction states that this remedy shows itself well when:

• Prevention of attacks of angina pectoris (stable) in combination with other antianginal agents;
• Relief of angina attacks;
• Monotherapy with intolerance of BCCC and beta-blockers.

Contraindications to admission

When should you not prescribe the pill "Cordynyk"? Instructions for use (synonyms of the drug mentioned below) speaks of such contraindications as:

• Collapse, cardiogenic shock;
• AV blockade of the third and second degree;
• Myocardial infarction is acute, and also within 90 days after it;
• Unstable angina ;
• Heart failure is chronic (third or fourth functional class according to the NYHA classification);
• Hypotension arterial;
• Period of pregnancy;
• Pronounced bradycardia;
• Lactation period;
• Left ventricular failure with low filling pressure;
• Underage age;
• Simultaneous use of phosphodiesterase-5 inhibitors (for example, Sildenafil, Vardenafil or Tadalafil);
• Hypersensitivity to the drug.

With caution, such pills are prescribed with a broken heart rhythm, prinzmetal angina, AV-blockade of the first degree, arterial hypotension, impaired liver and hypovolaemia kidney function, pulmonary edema, hyperkalemia, occlusive glaucoma and anemia.

The drug "Cordynik": the way of application and dose

Tablets "Cordynyk" should be taken inside, regardless of the meal.

The dosage of this drug is selected individually. As a rule, it depends on the duration and severity of the disease.

To stop an attack of angina, the medication should be used at the first signs of the disease. In this case, it is prescribed in a dosage of 20 mg. The tablet is placed under the tongue and held until it dissolves.

For the prevention of angina attacks stable (including long-term therapy), the drug is usually prescribed at a dosage of 10-20 mg three times a day.

The maximum dosage of this drug per day is 80 mg. With headaches, the initial dose may be reduced.

Adverse events

What you need to know before taking the pill "Cordynyk"? The instruction for use states that this product can cause such undesirable reactions as:

• Weakness, palpitations, headache, decreased blood pressure, dizziness;
• Tachycardia, noise in the ears, "tides" of blood to the skin of the face, insomnia;
• Allergic reactions, peripheral edema, nausea;
• Feeling of overflow in the stomach, vomiting, increased activity of "liver" transaminases, unpleasant sensations in the abdomen, stomatitis.

Overdose with pills

When a large number of tablets are taken, the patient has symptoms such as tachycardia and marked decrease in blood pressure. In this case, the affected person is washed with a stomach and activated charcoal. Also support the work of the cardiovascular system.

Interaction with other means

The antianginal effect of the drug in question is enhanced with simultaneous use of antidepressants, vasodilators, phosphodiesterase-5 inhibitors, antihypertensives and tricyclic antidepressants. The same applies to diuretics, MAO inhibitors, beta-blockers and ethanol.

Special Recommendations

Cancel the drug should be gradual. During therapy, it is necessary to monitor the parameters of ECG and blood pressure, as well as the content of sodium and potassium ions in the blood. Also, against the background of taking this medication, it is possible to intensify heart rhythm disturbances.

Analogues and synonyms of the drug, its cost

Now you know how the "Cordynic" medication works. Instructions for use, photos and properties of this medication were presented above.

How much does the drug in question cost? As a rule, the price of this drug for 60 tablets (10 mg) is 450 rubles. Although in some regions of our country this figure may be increased or, conversely, reduced.

In case of acute necessity, this medication can be replaced by such analogs as "Dilasidom", "Corvamin", "Carbocroman", "Corvaton", "Sidnofarm", "Oxicardin", "Reassanz" and others.

As for the synonyms, they include only the drug "Coronel".

Reviews about the drug

About the drug "Cordynyk" there are many positive reviews. Consumers argue that such an antianginal means completely copes with the task. The intake of the pills under consideration effectively stops angina attacks, and also eliminates the pain and discomfort of the sternum.

In addition, the merits of this drug include its availability and the ability to replace with analogs, and to the disadvantages - a high price and a large number of adverse reactions.