The medicine 'Azafen'. Reviews, indications, dosing regimen

The medicine "Azafen" is an antidepressant, sedative . The drug is available in the form of conventional tablets and with modified release. The active ingredient is pipethazine.

The instruction of "Azafen" tablets with modified release (MB) indicates that in them the active ingredient is enclosed in a special carrier matrix, which ensures a gradual release of pipophazine in the digestive tract. The active ingredient is absorbed quickly and almost completely in the digestive system. Pipofezin largely biotransformed in the liver with the formation of inactive metabolites. With the intake of (single) "Azafen MB" tablets, the maximum concentration in the blood is reached after three to four hours. The drug is present in the body on average a little over thirteen hours.

The medicine is excreted mainly with urine.

Medication "Azafen" (doctors' reviews confirm this) is effective in depressive disorders of moderate or mild severity (against the background of somatic pathologies of chronic course including).

The drug is contraindicated in disorders of kidney and liver activity of a pronounced nature, with hypersensitivity. Not prescribed medicine "Azafen" (reviews and comments of doctors confirm this) in pregnancy and lactation. It is not recommended to take the medication simultaneously with MAO inhibitors.

With caution, the "Azafen" remedy is prescribed (reviews of specialists are unambiguous in this regard) with IHD, chronic heart failure, myocardial infarction, infectious pathologies, conditions associated with cerebral blood flow disorders, as well as diabetes and childhood.

The medicine "Azafen" (patients' testimonials confirm this) is well tolerated. In rare cases, headaches, allergic reactions, dizziness may occur. Side effects include vomiting and nausea.

The drug "Azafen" instruction recommends taking inside at an initial dosage of twenty-five or fifty milligrams in two divided doses (in the morning and lunch hours). With good tolerability, the amount of the drug taken can be increased to 150-200 milligrams, divided into three or four doses during the day. Last reception is recommended before a dream. In some cases, the dosage may be four hundred milligrams per day. The optimal dosage is 150-200 mg. The maximum amount of a drug per day should not exceed four hundred to five hundred milligrams. After relieving the condition (achieving the desired result), the patient is transferred to maintenance therapy. Dosages in this case - from twenty-five to seventy-five milligrams a day. The duration of the drug is at least thirty to forty days. Duration of therapy can be a year.

The drug "Azafen MB" is prescribed in a dose of one hundred and fifty milligrams once or twice (in the evening and in the morning). In the appointment, the effectiveness of the medication and individual patient tolerance are taken into account. Modified-release tablets are administered after the optimal dosage is established using conventional Azafen tablets.

At the transition from MAO inhibitors to this drug is recommended to withstand a two-week interval.

Against the background of treatment, periodic monitoring of renal and hepatic function is carried out.

It is not recommended during the therapeutic course to engage in potentially hazardous activities, work with mechanisms or complex equipment, and manage transport.

During treatment should refrain from taking alcohol.

Before using the drug "Azafen" you need to consult a doctor and carefully study the annotation.