The drug 'Nitroxoline'. Instructions for use

The drug "Nitroxoline" is available in the form of round, orange-colored tablets, coated with a shell. Medication belongs to the pharmacotherapeutic group of antimicrobial agents. The active component of the drug is nitroxoline.

Antimicrobial and antiprotozoal properties of the drug allow it to be used in the treatment of infections of the genitourinary system. The drug "Nitroxoline" selectively suppresses the synthesis of bacterial DNA, forms complexes with metal-containing enzymes. Thus, the drug exhibits activity against bacteria, both gram-negative and gram-positive.

As a result of individual studies, the efficacy of the drug was established in the absence of therapeutic result from the use of other antimicrobial agents.

The drug "Nitroxoline". Instructions. Appointment

The drug is indicated for infections of the urinary tract and kidneys, provoked by bacteria sensitive to the active ingredient of the drug. They include prostatitis, epididymitis, urethritis, pyelonephritis, cystitis.

The medication Nitroxoline recommends the use as a prophylactic in the postoperative period after interventions in the genitourinary system, kidneys, as well as to prevent complications in medical and diagnostic manipulations (for cystoscopy, catheterization, for example).

Dosing regimen

The drug "Nitroxoline" instruction recommends taking after or during meals orally (orally). The recommended amount of medication per day for adults is 400 mg (four times at 100 mg). If necessary (as agreed with the doctor), the dosage per day may be increased to 600-800 mg, not more. Duration of use is from two to three weeks.

The drug "Nitroxoline" for children from three to five years a day is recommended in a dosage of 200 mg. Patients older than five years - 200-400 mg. The daily dosage is divided into four doses.

With infections of the genitourinary system of chronic course, the drug "Nitroxoline" allows the instruction to be prescribed by repeated two-week courses. In this case, a break is required - two weeks (between courses).

For the prevention of postoperative complications, the drug is recommended in a dose of 100 mg 4 times a day. Duration of application - two to three weeks.

Admission of the drug "Nitroxoline" can cause allergies (rashes on the skin), dyspeptic reactions (vomiting, nausea). In some cases, there may be a disorder of kidney function, polyneuropathy, headache, ataxia (impaired coordination), paresthesia (numbness), tachycardia. Prolonged use of the drug provokes defeat in the optic nerve, myelopathy, peripheral neuritis. Probable accumulation of the active substance can manifest itself in the form of general weakness, vomiting, nausea. As a rule, these phenomena are independently eliminated after stopping the medication.

Contraindications

The drug "Nitroxoline" is not recommended for hypersensitivity to its components and other means of quinoline group, polyneuritis, neuritis, cataracts. Contraindications include hepatic, renal failure, deficiency of glucose-6-phosphate dehydrogenase. The drug "Nitroxoline" during pregnancy and during lactation is also not prescribed.

special instructions

During the treatment, the color of urine may change.

The drug has no effect on the rate of reactions and the ability to concentrate attention.

In clinical practice cases of overdose are not described.

To prevent dyspeptic reactions (nausea, vomiting) is recommended taking with food.

The use of the drug "Nitroxoline" in young children is carried out only under the supervision of a doctor.

Before using the medication, you need to carefully study the annotation.