"Moxonidine": instructions for use, reviews

What is Moxonidine? Instructions for the use of this tool, reviews about it, contraindications and analogues will be described in detail in this article. In addition, we will tell you about what the intended means for us are, whether it has side effects and in what form it is produced.

Form and composition of medicament

In what form can I take medicine "Moxonidine"? This drug is sold only in the form of tablets. Their active element is a substance such as moxonidine. As for the additional components, they include microcrystalline cellulose, castor oil, aerosil A-380, hydroxypropylcellulose, magnesium stearate and tween-80.

Tablets are sold in a cardboard box. In one package can be 98, 60, 56, 42, 40, 30, 28, 20, 14 and 10 tablets.

Pharmacological properties of the medicinal product

What is the use of the drug "Moxonidine"? Instructions for use say that this drug is an antihypertensive drug. Its mechanism of action is that the active substance of the agent affects the central links of the regulation of blood pressure. In other words, moxonidine is an imidazoline receptor agonist (to a greater extent).

The drug depresses the activity of the vasomotor center, reducing the descending sympathetic effects on the cardiovascular system. At the same time, the pressure (both diastolic and systolic) decreases gradually.

The drug considered by us differs from other antihypertensive sympatholytic agents in that it has only a slight affinity with alpha-2-adrenergic receptor. This explains the low probability of dry mouth and sedative effect.

One can not help saying that moxonidine is able to increase the index of insulin sensitivity (by about 21 percent) in obese people.

Pharmacokinetics of the drug

Where is Moxonidine absorbed? Instructions for use say that after taking the medication instantly and almost completely absorbed in the upper parts of the digestive tract.

Bioavailability (absolute) of this remedy is 88 percent. The maximum concentration is achieved in sixty-five minutes. At the same time, the use of food has no effect on the pharmacokinetics of the active element.

The connection with blood proteins is about 7.3%. The main metabolite of moxonidine is moxonidine dehydrogenated, as well as derivatives of guanidine.

The half-life of moxonidine and its metabolites is 150 and 300 minutes, respectively.

After oral administration for twenty-four hours, the drug is excreted by the kidneys in a volume of 90%. Also, the active substance exits through the intestine.

Indications for use of a medical device

In what cases is a "Moxonidine" medication prescribed? The use of this drug is shown only with such pathology as arterial hypertension.

Contraindications to the use of a medical device

In what cases do doctors not prescribe to their patients the medicine "Moxonidine"? Instruction for the use of this drug contains a not very long list of contraindications. Consider it right now.

So, the following factors are contraindications to the use of the drug "Moxonidine":

• Expressed AV blockade of 2 and 3 degrees, SSSU;
• Pronounced bradycardia (less than 50 beats per minute);
• Adolescence and children's age (under 18 years);
• Chronic and acute heart failure;
• Period of feeding the baby;
• Hypersensitivity to the active element.

Medication "Moxonidine": instructions for use

Patients' comments about this medication will be presented at the very end of the article. Now I want to tell you about how to properly use the drug we are considering.

The drug "Moxonidine" is taken only by mouth. Dosage at the beginning of drug therapy should be 200 μg once a day. At a time you can take 400 mcg.

Individual adjustment of the daily amount of the drug is required depending on the tolerability of drug therapy. According to the instructions, the maximum dosage of the drug per day is 600 μg (divided into two doses).

For patients with renal failure (severe and moderate), as well as people on hemodialysis, the drug is prescribed in an amount of 200 μg once a day. If necessary (with good tolerability), then the indicated dosage can be increased to the maximum (that is, up to 400 μg).

Side effects after taking medication

Are side effects caused by Moxonidine? The patient's comments about him say that sometimes a medicine really becomes a cause of deterioration of well-being. Let us consider what list of side effects the instruction contains:

• Nervous system (central): headaches, fainting, dizziness and drowsiness.
• The digestive tract: vomiting, dry mouth, diarrhea, dyspepsia and nausea.
• System cardiovascular: aetiology, pronounced lowering of arterial pressure, orthostatic hypotension.
• Skin and subcutaneous tissue: angioedema, itching and skin rash.
• Mental disorders: nervousness and insomnia.
• Labyrinth disorders of the organ of hearing: ringing in the ears (it happens very rarely).
• Musculoskeletal system: back pain, neck pain.
• Common side effects: peripheral edema and asthenia.

As you can see, Moxonidine tablets can cause deterioration of the patient's condition. If the side effects are clearly pronounced, then the medication should be stopped.

Interaction of the drug with other medicinal products

To drugs "Moxonidine", "Moxonidine Sandoz" and other analogs of the medication helped the patient, and did not do him more harm, they should be taken only as prescribed by the doctor. Because the simultaneous use of this drug with other drugs can cause unwanted reactions. Which ones, we will consider right now.

A single use of the drug "Moxonidine" with similar antihypertensive drugs can lead to an additive effect.

Antidepressants (tricyclic) reduce the effectiveness of antihypertensive drugs of central action. In this regard, they are not recommended to be used in conjunction with a substance such as moxonidine.

The drug we are considering can easily enhance the effect of tranquilizers, tricyclic antidepressants, as well as ethanol, hypnotics and sedatives.

The active substance of the drug moderately improves the weakened cognitive functions of people who simultaneously receive lorazepam.

With the simultaneous administration of "Moxonidine" and "Benzodiazepine" preparations, the sedative effect of the derivatives of the latter may be enhanced.

Specialists say that moxonidine is excreted by tubular secretion. In this regard, it should not be used together with drugs that are also secreted through tubular secretion.

The period of gestation and breastfeeding (pregnancy and lactation)

Is it possible to take a medication "Moxonidine-LF" during the gestation period? The drug's instruction contains information that strictly controlled and adequate studies on the safety of the drug in question have not been carried out during pregnancy. That is why it is not recommended to apply this category of patients.

One can not help saying that the drug "Moxonidine" should not be used during breastfeeding. This is due to the fact that it is excreted together with the mother's milk. If the drug was still prescribed during lactation, then breastfeeding should be discontinued.

In the course of research (experimental) in animals, it was found that this medication acts embryotoxically.

Special instructions on the use of medicament

According to the attached instructions, during the use of the drug "Moxonidine" should be very careful. This is especially true for a particular category of patients. Which one, we will tell right now.

Particular care when using the drug "Moxonidine" should be observed patients with AV-blockade of the 1st degree. This is due to the fact that these people have a high risk of developing a bradycardia.

Also, the medication should be administered under the supervision of a doctor for severe coronary artery disease, kidney failure and unstable angina. This fact is due to the fact that the experience of using the drug with such deviations is insufficient.

If it is necessary to cancel the simultaneous use of "Moxonidine" and beta-blockers, then the last remedy is first canceled, and in a few days - the second.

To date, there is no information that the discontinuation of the drug "Moxonidine" leads to an increase in blood pressure. However, despite this, experts still recommend gradually canceling the medication. Dosage should be reduced for two weeks.

Does the drug affect the ability to drive cars?

During drug treatment with Moxonidine, people should be especially careful when practicing hazardous activities, as well as while driving motor vehicles. This is due to the fact that taking a medication can disrupt concentration and psychomotor reactions.

Analogues and cost of a medicinal product

You can buy the drug "Moxonidine" in the pharmacy without a doctor's prescription. The cost of this medication is relatively low. For the package, which contains 14 tablets, you will have to pay approximately 115-135 Russian rubles.

If the drug we are considering does not suit you, or you simply could not find it in the pharmacy, then after consulting a specialist, the latter is obligated to recommend you an analogue of the drug. Among these medicines I would like to highlight the following: "Physiotenses", "Moxonidine-S3", "Moxarel", "Moxonidine Canon", "Moxonitex", "Moxogamma", "Tenzotran" and so on.

Take these funds should be strictly according to the appointment of a specialist. Also, before using the medication, you should read the attached instructions.

Medication "Moxonidine": reviews of doctors and patients

According to experts, this drug is very effective in hypertension. The same opinion is shared by patients. However, some of them complain that after taking the pills after a while they have such side effects as headaches, dry mouth, nervousness and nausea. In this case, doctors recommend to cancel the drug and replace it with an analogue, which will be safer for health.