The drug 'Amikacin': instructions for use

Pharmacological action of the drug "Amikacin", the instruction for use describes as follows. This antibiotic has a wide range of effects, it is a semi-synthetic substance and belongs to the pharmacological group of aminoglycosides.

Composition of the preparation "Amikacin", form of release.

The drug "Amikacin" is manufactured by manufacturers in the form of a solution or a dry powder for injection. Vials or ampoules with medication are available in bulk from 0.05 to 0.5 grams, and the mass of powder for injection in vials is 0.1 or 0.5 grams. The main active substance of the drug is amikacin sulfate.

The international name of the medicinal product and its name on the INN registry is amikacin.

"Amikatsin" has a bacteriolytic effect. It is highly active against such gram-negative and Gram-positive microorganisms as Pseudomonas aeruginosa, salmonella, staphylococcus. In addition, this antibiotic is active against microorganisms that show resistance to penicillin and methicillin. "Amikatsin" suppresses the action of strains of some ostreptococci. The drug has the ability to form high concentrations in the urine, is excreted mainly by the kidneys.

For the use of Amicacin, the instructions for use establish the following indications. It is effective in treating such bacterial infections as sepsis and peritonitis, including severe disease. Apply a medicine for the treatment of meningitis, osteomyelitis, infectious diseases of the skin in a purulent form of their course, endocarditis. They are also used for pneumonia, treatment of various forms of burns, lung abscesses and other infectious diseases.

For the drug "Amikacin" the instruction for use establishes the following mode of application and dosage. First of all, it should be borne in mind that the appointment of the drug is performed by a doctor solely on the basis of an individual approach to the patient's condition. The main criteria here are the severity of the course of the disease, the degree of its localization, as well as the presence of hypersensitivity in the patient to the components of the drug. The most commonly used intramuscular injection, but in some cases, as prescribed by the doctor, can be used jet or drip intravenous drug administration .

Doses of drug administration are recommended as follows:

- with an average severity of the course of the infectious disease, adult patients and children, the daily dose equals 10 micrograms of active substance per kilogram of weight. The drug is administered two to three times a day;

- for newborn babies, or those born prematurely, the initial single dose of administration is 10 mg / kg, after which they inject 7.5 mg / kg every other half a day;

- in case of using a medicine for the treatment of diseases that are caused by the action of Pseudomonas aeruginosa, or in cases of a threat to the life of the patient, the dose is increased to 15 mg / kg with a triple intake.

When using the drug Amikacin, the instructions for use recommend a treatment time of three to seven days, with iv introduction, and seven to ten days, with an IM injection. If patients have violations related to renal dysfunction, then a correction of the drug regimen is necessary. The criterion for making a decision, in this case, is the creatinine clearance.

Use of the drug may be accompanied by a number of side effects: skin rash, itching, anemia, headaches. The more severe side effects are specified in the instructions.

Caution should be applied "Amikatsin-vial" for the treatment of elderly patients. It should refrain from taking the drug in the presence of hypersensitivity to its components, as well as in cases of diagnosis in patients with severe functional disorders of kidneys.

The instruction recommends the use of the drug in combination with carbenicillin, which significantly improves its effectiveness. But with simultaneous admission with diuretics - "Furosemide" or "Uregit," the risk of side reactions increases.