"Reaferon-Lipint": reviews, instructions, analogs, application, price

The agent "Reaferon-Lipint" is an antiviral drug that was created on the basis of interferon. The composition of this drug includes dried recombinant alpha-2-beta human interferon. Medication, like other medicines, which also includes this compound, helps to strengthen one's own immunity. The use of these drugs is carried out with various infectious lesions, when our own health is weakened. For example, in the process of immunotherapy, with systemic diseases.

"Reaferon-Lipint" is applied:

• When conducting during the epidemic of ARVI prophylaxis.
• In the case of systemic ailments, such as atopic dermatitis, asthma, etc.
• With viral hepatitis B - in both acute and chronic form.

"Reaferon-EU-Lipint" is available in the form of a powder. Distilled or boiled water is added to the bottle immediately before use , and then everything is vigorously shaken. According to the instruction, this preparation is recommended to be taken half an hour before a meal. However, a doctor must write down his own scheme of application specifically for each patient. As a rule, the general course of treatment is not more than one month.

Existing forms of output, price

• Powder lyophilized 500 000 IU / ml (for oral administration) - the price is about 700 rubles.
• For the preparation of the suspension, the powder lyophilized 1 000 000 IU (for oral administration) - the price is approximately 1000 rubles.
• To prepare the suspension, the powder is lyophilized 250,000 IU (for oral administration) - the price is approximately 410 rubles.

«Reaferon-Lipint»: analogues

This medication has the following analogues:

• "Infagel".
• "Viferon-ointment."
• "Viferon."

Indications for use

Powder lyophilized 1 000 000 IU and 250 000 IU for internal use is recommended to use in the following cases:

• Treatment and prevention of acute viral respiratory infection and influenza.
• Multiple sclerosis.
• Kaposi's Sarcoma AIDS-related.
• Reticulosarcoma.
• Mushroomed mycosis.
• Kidney cancer.
• Multiple myeloma.
• Transitional form of granulocyte chronic leukemia and myelofibrosis.
• Primary and secondary thrombocytosis.
• Active viral hepatitis C.
• Myeloleukemia in chronic form.
• Hairy cell leukemia.

Powder lyophilized 500000 IU / ml "Reaferon-Lipint" in the form of an ointment is used for viral damage of mucous membranes and skin of various locations.

In the form of a suppository, this drug is used in complex therapy for such ailments as:

• Infectious-inflammatory childhood diseases, including in premature and newborn children.
• Meningitis.
• Sepsis.
• Influenza, ARVI, including complications of bacterial infection.
• Chlamydial, viral and bacterial pneumonia.
• Intrauterine infection - enterovirus infection, CMV infection, herpes, chlamydia, candidiasis, including visceral mycoplasmosis.
• Viral chronic hepatitis B, C, D in adults and children, including combined hemosorption and plasmapheresis of viral chronic hepatitis with cirrhosis of the liver and a pronounced degree of activity.

As interferon-correcting agent "Reaferon-Lipint" (the price is resulted above) is applied in case of presence of following diseases:

• Urogenital infection (papillomavirus infection, mycoplasmosis, vaginal recurrent candidiasis, gardnerellez, trichomoniasis, ureaplasmosis, bacterial vaginosis, CMV infection, chlamydia).
• Recurrent or primary infection of mucous membranes and skin.
• Influenza and other ARI and ODS, including those complicated by adults with a bacterial infection.

Contraindications

The drug "Reaferon-Lipint" (the price depends on the form of release) has the following contraindications:

• Disrupted kidney, liver, or circulatory system.
• Hypersensitivity.
• Chronic hepatitis in patients who received shortly before this therapy with immunosuppressants (the exception is a short-term preliminary treatment with steroids).
• Myocardial infarction.
• Chronic hepatitis caused by decompensated cirrhosis of the liver.
• Severe heart disease (including history).
• Epilepsy or other disorders of the central nervous system.

In addition, the "Reaferon-Lipint" (reviews about the drug see below) has some limitations to the application:

• High sensitivity to the constituents of the preparation.
• Lactation.
• Pregnancy.

Side effects

Powder lyophilized for ingestion of 1 000 000 IU and 250 000 IU "Reaferon-EU-Lipint" (the price depends on the form of release) has the following side effects:

• Skin allergic reactions (eg, itching or rash).
• Sleep disturbance.
• Nervousness.
• Violation of consciousness.
• Drowsiness.
• Depression.
• Ischemic retinopathy.
• Visual disturbance.
• Dizziness.
• Hepatitis.
• Violation of the function of the liver.
• Heartburn.
• Increased peristalsis.
• Flatulence.
• Constipation.
• Stomach ache.
• Chills and fever
• Diarrhea.
• Decreased body weight.
• Dryness in the mouth.
• Change in taste.
• Vomiting and nausea.
• Sweating.
• Pain in the joints.
• Headache or muscle pain.
• Poor appetite.
• Lethargy.

"Reaferon-Lipint" for children powder lyophilized 500 000 IU / ml:

• Ointment - side effects are not noted.
• Suppositories - allergic reactions (eg, itching or rash) are rare.

Interaction

Interferon alfa reduces the activity of P-450 cytochromes, which affects the metabolism of warfarin, propranolol, diazepam, theophylline, curantyl, phenytoin, cimetidine and some cytostatics. And it can also increase the cardiotoxic, neurotoxic or myelotoxic effect of drugs that began to be taken concurrently with it or earlier.

In addition, it is necessary to avoid the co-administration of Reaferon-EU-Lipint (price mentioned above) with CNS suppressants, as well as immunosuppressive drugs (including parenteral and oral forms of corticosteroids).

It is strictly forbidden to take alcohol during treatment.

Possible doses

The drug is taken half an hour before meals inside. For prevention of acute respiratory infections and influenza - 1 capsule (500 000 IU) per day, for a month 2 times a week. When treating ARVI and influenza - 1 capsule (500 000 IU) daily for 5 days 2 times a day. If swallowing is difficult, it is allowed to open the capsule gently and take the contents with a little water.

Dosing and Administration

This medication is used orally. Before its immediate application, the contents of the vial are added chilled boiled or distilled water (1-2 ml). As a result of shaking about 1-5 minutes, a homogeneous mass should appear.

1. In the case of acute hepatitis, the drug is taken 30 minutes before meals as follows:

• Children from 3 to 7 years - the drug is taken 10 days once a day for 500 000 IU. After biochemical control studies of blood "Reaferon-Lipint" for children (the price depends on the form of release) is applied for a longer time - until the onset of complete clinical recovery.
• Children over 7 years and adults - 10 days 2 times a day for 1 000 000 IU.

2. In the case of chronic hepatitis B in replicative forms (active or inactive), including chronic hepatitis B associated with glomerulonephritis, this drug should be taken 30 minutes before meals as follows:

• Children from 3 to 7 years should take this drug 10 days 2 times a day for 500 000 IU, then - for 1 month once a day (preferably at night) every other day for 500 000 IU.
• Children older than 7 years and adults - 10 days 2 times a day for 1 000 000 IU, after which for 1 month 1 time per day (at night) every other day.

3. In case of specific therapy, "Reaferon-Lipint" (reviews below) should be applied 30 minutes after eating in the morning hours according to the following scheme:

• In the case of atopic bronchial asthma, adults - for 10 days daily 500 000 IU. Then, within 20 days every other day, 500,000 IU. The total duration is 30 days.
• In the case of allergic rhinoconjunctivitis - for 10 days daily for 500 000 IU.

4. For the purpose of prevention and treatment of acute respiratory disease and influenza, this drug is taken half an hour before a meal. "Reaferon-Lipint", the instruction for use confirms this, it is necessary to drink as follows:

• When treating ARI and the flu - for 3 days daily 2 times a day for 500 000 IU.
• For the prevention of acute respiratory disease or influenza - when the incidence rate increases, the drug is taken for 1 month 2 times a week once a day for 500 000 IU.

Overdose

Cases of exceeding the dosage of this drug were not observed. It is only possible to increase the dose-dependent side effects. When overdosed, symptomatic treatment is provided.

Similar titles

"Eberon Alfa R", "Reaferon-EU-Lipint" for children, "Realdiron", "Alfarona", "Layfferon", "Intron-A."

Storage of the drug

It is desirable to store the drug out of reach of small children, protected from sunlight. The storage temperature should not exceed 8 ° C.

Special Recommendations

The drug has no effect on the ability to manage potentially dangerous mechanisms and vehicles. If allergic reactions occur, seek medical help immediately.

How is it released

"Reaferon-Lipint" for children (reviews below) is only released with a prescription from a doctor.

Expert Reviews

This drug simultaneously possesses not only antitumor and antiviral activity, but also the ability to restore the immune system. It has been widely used due to the treatment of viral hepatitis B, like other antiviral drugs, the earlier it was prescribed, so, accordingly, there is more hope for an antiviral effect. After 5 days after the disease, jaundice is no longer prescribed.

In addition, this drug is used in the case of viral meningoencephalitis, but only in the first four days of the disease. More "Reaferon-Lipint" is actively used in keratitis and viral conjunctivitis. Antitumor activity allows us to prescribe this drug for certain types of cancer, especially in cancerous blood diseases. Excellent results were obtained in the treatment of multiple sclerosis.

It was noted that some categories of patients are severely affected by the use of this drug: fatigue, weakness, fever, chills. However, despite this, the treatment course, in most cases, needs to be continued.

Sometimes during treatment there is a sharp decrease in the blood of platelets and white blood cells, which requires a control blood test and medical supervision (approximately 2-3 times a week). Despite the side effects, as a rule, immediate withdrawal of the drug is excluded, since the decision to cancel it should be taken exclusively with a specialist who appointed Reaferon-EU-Lipint. This is due to the fact that the expected benefit is so great that the decision on cancellation requires a deliberate and maximally balanced approach.

Benefits

• The basis of this drug is scientific development, which is awarded the RF Government Prize.
• Compared with other drugs, "Reaferon" should be taken orally (orally). This factor is especially relevant in pediatrics.
• Liposomal interferon is great for emergency prevention of ARVI and influenza, when there was a contact with the virus, but there are no symptoms of the disease or they are only barely noticeable.
• Liposomes promote long circulation in the blood of interferon.
• "Reaferon" acts as an inductor, that is, it contributes to the development of its own interferon.

The composition of the drug includes recombinant interferon, which was developed by the genetic engineering method in the laboratory. In other words, this drug is not a product of natural blood and it can not contain dangerous infections.

special instructions

As it was said earlier, in the process of taking this medication it is necessary to avoid its combination with immunosuppressants, as well as medical preparations that are capable of exerting any influence on the central nervous system. Throughout the course, it is very important to monitor the function of the liver and the blood content of the elements. To somewhat alleviate influenza-like symptoms (side effects), it is desirable to simultaneously appoint paracetamol while taking this medication.