Pathology or norm - a common protein will tell

By the term total protein means a vast concept, which includes all the proteins that are contained in the blood, and there are really a huge number of them. All of them are different in structure, function and chemical-physical properties. Basically, the division occurs on albumins and globulins, but fibrinogen is also present.

Norm

Normally, the amount of total protein depends on the person's age. In a newborn who has not turned a month, this index is from 46.0 to 68.0 g / liter, in a premature baby this indicator can be reduced, the norm in this case ranges from 36 to 60 g / liter. Total protein in children - the norm of this indicator from one month to a year is 48.0-76.0, and from year to 16 years - 60.0-80.0 g / liter. In adults, the person gives the total protein in the range of 65.0 - 85.0 grams per liter, and after 60 years this indicator can be reduced by about 2 g / l.

This indicator helps to assess the indicators of hemostasis, thanks to it, blood acquires its basic properties, such as viscosity and fluidity. The concentration of protein in the blood depends on the ability of the elemental elements to be kept in a suspended state. Also due to proteins transport of various substances, protection of the body is carried out.

In the clinic is not uncommon disease, in which the change in the total protein of serum . A blood test will help to establish whether the pathology in this case or vice versa is the norm. A common protein will give the doctor a clearer idea. Increased its content is called hyperproteinemia, and decreased - hypoproteinemia.

Increase in total protein

The increase in the total protein can be both absolute and relative. There are a number of diseases in which the total protein is relatively elevated. The norm in men and women of this indicator is the same, but for burns, peritonitis, intestinal obstruction, vomiting or vice versa, diabetes, sugar or non-sugar, kidney disease or increased sweating, this indicator is increased relatively.

If there is an absolute increase, then this indicates that in the body there is a process that can harm him, and this is not the norm for him. The total protein in the blood at the same time increases due to pathological fractions, which are called paraproteins, as well as due to inflammation proteins. In this case, it is worthwhile to suspect myelomium disease, the protein at it rises to 120-160 g / l, Hodgkin's disease and polyarthritis, chronic or acute infectious process, active hepatitis, cirrhosis, sarcoidosis and autoimmune diseases.

Decrease in the total protein

Hypoproteinemia can also be absolute or relative, which is also not the norm. Total protein decreases with water load, absence or decrease in urine, cardiac decompensation, large intravenous infusion of glucose solution, when renal secretion is impaired, when an increased antidiuretic hormone that delays urinary excretion.

Absolute decrease is due to a decrease in albumins, which can also be characterized as not the norm. The total protein is lowered if there is insufficient protein intake with food or increased excretion of it - with starvation, enteritis, colitis. Its production decreases with hepatitis, cirrhosis, intoxication, congenital pathology - albuminemia, Wilson-Konovalov's disease. Increased disintegration can occur with oncology, burns, increased thyroid function, in trauma, after surgical treatment, with fever or prolonged treatment with corticosteroids. The index of the total protein in ascites or pleurisy decreases when it is lost along with the fluid, or in diseases of the kidneys. Physical activity, as well as the last months of pregnancy and lactation, contribute to hypoproteinemia in women.