Tablets "Pyrazinamide" have a bactericidal or bacteriostatic anti-tuberculosis effect depending on the concentration. The activity of the medicament is preserved only under acidic conditions (at a pH of 5.6 and below). On The development of resistance, the probability of which decreases with the use of a medicament with other antituberculous agents, is possible for the preparation of the drug. The drug "Pyrazinamide" (the instruction for use confirms this) is most effective in destructive tuberculosis, which was first discovered, in cases of caseous-pneumonic type, tuberculoma, caseous lymphadenitis. The drug lowers the transport of urate and uric acid, can provoke hyperglycemia. The drug from the digestive tract is almost completely and quickly absorbed. With plasma proteins, the drug binds to 10-20%. After an hour or two, the maximum concentration of the drug is observed. The medication is well distributed among the fluids and tissues, is deposited in organs, including the lungs, liver, kidneys, as well as encapsulated areas of tuberculous lesion. The product passes the BBB. Metabolism occurs in the liver.
Indications
The drug "Pyrazinamide" (experts' reviews confirm this) is the first choice in the treatment of tuberculosis.
Dosing regimen
It is established that monotherapy is not effective enough. In connection with this, the "Pyrazinamide" medication is recommended for use in combination with other drugs with anti-tuberculosis activity. For adults, the dosage is 30-35 mg / kg once a day. For patients whose weight does not exceed fifty kilograms, this dose is equal to three tablets (1.5 g). At a weight of more than 50 kg should take 4 tab. (2 g). For children, the maximum dosage is 2 grams. The drug is taken with food. It is recommended to drink the medicine during breakfast.
Means "Pyrazinamide". Instructions for use. special instructions
The medicine does not cause an overdose if the prescription of the doctor is observed. When taking a large amount of medicine, there are negative effects from the central nervous system - dizziness, headaches and others. There is a disorder Liver activity, dyspeptic phenomena are likely . Poisoning shows symptomatic treatment. Monthly monitoring of bilirubin, AST, uric acid and ALT levels is carried out before and during the course of antituberculous therapy in patients after 60 years of age. In disorders of liver function, drug withdrawal is necessary. Diabetic patients are more likely to develop hypoglycemia. When combined with medication "Rifampicin" can be noted hepatotoxicity. In complex application with the drug Probenecid, a decrease in excretion is likely and, as a result, an increase in toxicity. There may be cross-sensitivity with medicines "Isoniazid", "Ethionamide", acid of nicotine and other means having a similar chemical structure. The drug "Pyrazinamide" (instruction for use confirms this) is suitable for five years. Store the drug in closed containers, in places protected from light.