Ademethionin: instructions for use, analogues, reviews

What is ademethionin? Instructions for the use of the preparation containing this component will be described later. Also we will tell you about how much a similar tool costs, what users are saying about it, and so on.

Form of the drug, its description

In what form is produced the preparation "Geptral" (INN "Ademetionin")? Instructions for use asserts that this tool can be purchased in two different forms:

• Lyophilizate, intended for the preparation of intramuscular or intravenous solution. This form is a lyophilized mass of white color, without foreign inclusions. Also in the cardboard pack contains a special solvent, which has the appearance of a colorless and transparent liquid.
• "Ademetionin" - tablets in a shell of white color, biconvex and oval. In addition to the active substance of the same name, it also contains auxiliary elements such as MCC, Na-carboxymethyl starch, silicon dioxide and Mg stearate.

Pharmacodynamic features

What are the properties of ademethionin? The instruction for use states that the said ingredient exhibits choleretic, cholekinetic, detoxifying, neuro- and hepatoprotective, as well as antidepressant and antioxidant effects.

Thus, it can be safely noted that the considered drug element is capable of enhancing bile secretion, as well as provoking its secretion into the intestine.

It should also be noted that the drug "Ademethionine", the analogues of which are indicated below, makes up for the shortage of SAM, and also stimulates its formation in the liver. In addition, this agent increases the plasma concentration of cysteine, taurine, glutamine in the liver, thereby normalizing all metabolic processes in the liver and decreasing the level of methionine in the serum.

What are the most effective conditions for Ademethionine? Instructions for use indicate that this drug is well manifested in the protocol and hepatic tubular cholestasis. It carries out conjugation and sulfation of the LC in the liver cells, and then reduces their toxicity.

According to reports of specialists, choleretic and hepatoprotective effects after the termination of therapy by "Heptral" are kept up to 3 months.

When administered to people with opium addiction accompanied by liver damage, it improves the function of this organ, the processes of monooxygenase oxidation, and also contributes to the regression of clinical symptoms of drug abstinence.

The antidepressant effect after the application of the drug in question develops gradually. At the same time, it stabilizes for two weeks.

Kinetic capacity of the agent

Is the drug Ademethionin absorbed? Instruction for use informs that when taken orally, its bioavailability is 5%, and when using the injection solution - 100%.

The peak concentration of this drug in the blood with a single intake of one tablet is observed for 2-6 hours.

In the state associated with plasma proteins, this agent is only in a small amount. It should also be noted that this drug penetrates well through GEB, and in high concentrations it is easily detected even in CSF.

Biotransformation this medicine is exposed in the liver. Its half-elimination time is 1.5 hours. The medication is mainly kidneyed.

Indications for prescribing

What is the drug "Ademetionin" (the price of the drug is indicated below)? This remedy is very often prescribed when:

• Symptoms of depression;
• Intrahepatic cholestasis with cirrhotic and precirculatory conditions, including fatty liver dystrophy;
• Cholecystitis chronic besskamennom;
• Chronic hepatitis;
• Cholangitis;
• Toxic liver damage of various origins, including viral, alcoholic and medicinal (tricyclic antidepressants, antibiotics, antiviral drugs, antitumor and antituberculosis drugs, oral contraceptives);
• Cirrhosis of the liver;
• Intrahepatic cholestasis in pregnant women;
• Encephalopathy, including those associated with hepatic insufficiency (alcoholic).

Prohibitions to use

Under what conditions can not prescribe the drug "Ademetionin" or "Heptral"? This remedy is prohibited for use in genetic disorders affecting the methionine cycle, as well as causing hyperhomocysteinemia or homocystinuria. Also, it is contraindicated for admission in childhood and adolescence and with high sensitivity to ademetionin.

Method of application of tablets "Ademethionine"

Experts say that the drug should be taken orally between meals in the morning, without crushing or chewing. In this case, the tablet must be removed from the package right before use.

The daily dosage of this drug is 2-4 tablets, and the duration of therapy depends on the available indications.

Instructions for use of the solution

How should I use Ademethionin injection solution, analogues of which can be found in any pharmacy? This drug, released in ampoules, is administered intramuscularly or intravenously. In this case, intravenous injection is very slow.

The medicinal solution is prepared right before the injection, using for dilution of lyophilized powder the solvent, which is in a cardboard bundle.

After the injection, the remaining drug should be disposed of.

It should be especially noted that the injection form of "Ademetionine" is incompatible with alkaline solutions and preparations containing Ca ions.

The daily dosage of the drug with VPC is 1-2 ampoules. Treatment with this medication lasts for two weeks.

With a depressive condition, the drug in question is used in a similar dose. In this case, the injections are carried out for 15-18 days.

If the patient requires supportive treatment, then he is transferred to the tablet form of "Heptral."

Adverse events

What negative reactions can the drug "Ademethionin" (400 mg) cause? Most often in the background of treatment with this drug, patients experience diarrhea, abdominal pain and nausea.

In rare cases, the use of a solution of "Heptral", as well as its tablet form can cause development:

• UTI (i.e., urinary tract infections);
• Edema of the larynx, hypersensitivity reactions;
• Paresthesia, anxiety, headache, insomnia, dizziness, confusion;
• Itching, skin manifestations of allergies, rash, swelling of Quincke, sweating;
• Inflammation of the superficial walls of the veins, disruption of the work of the heart and blood vessels, tides;
• Bloating, dry mouth, vomiting, esophagitis, nausea, abdominal pain, diarrhea, dyspepsia, functional disorders of the digestive tract, meteorism, hepatic colic, liver cirrhosis, bleeding from various parts of the gastrointestinal tract;
• Joint pain, muscle spasm;
• Malaise, flu-like syndrome, fever, chills, peripheral edema, asthenia.

The cost of the medicine, its analogs and reviews

How much is a medication such as Ademethionin? The price of this drug is about 1500 rubles per tablet form and about 1900 rubles per injection.

If desired, the medication in question can be replaced by such drugs as Glutamic Acid, Carnithen, Histidine, Carnitine, Epilaptone, Elcar.

What do users say about this drug? According to reports of patients who have experienced liver disease, the drug "Ademetionin" is the only real hepatoprotector. Patients with a diagnosis of "cirrhosis" argue that the best results of treatment can be achieved only if the drug is taken 2 times a year by 3-month courses.

As for doctors, they report that the drug "Ademetionine" does indeed have a pronounced and rapid effect on inflammatory liver diseases, accompanied by stasis of bile in the tissues of this organ.