"Vazonit": reviews, analogs, instructions for use

Is it effective such a medicine as "Vazonit 600"? Reviews about this drug you can find a little further. Also, the materials of this article provide information on how to take this medication, when it is prescribed, and in what cases it is prohibited.

Composition and form

In what form do they produce Vazonit? The reviews say that this remedy can be purchased in the form of oblong white and biconvex tablets with a risk on both sides. They have a prolonged action, and are also coated with a film sheath and placed in blisters, which are in a cardboard package.

The composition of the drug in question is pentoxifylline (active substance) and such auxiliary elements as crospovidone, hypromellose 15000 cP, colloidal silicon dioxide, microcrystalline cellulose and magnesium stearate.

With regard to the coating of tablets (film), it consists of macrogol 6000, talc, titanium dioxide, hypromellose 5 cP and polyacrylic acid as a 30% dispersion.

Pharmacology

What is a preparation such as "Vazonit 600"? The opinion of the doctors states that the given agent is capable of the following actions:

• Protect the walls of the vessels from adverse effects (i.e., have an angioprotective effect);
• Improve microcirculation of blood in places of impaired blood circulation (due to improved rheological properties of blood, or so-called fluidity);
• Prevent thrombogenesis (that is, have anti-aggregation effect);
• To relax the smooth muscles of the walls of blood vessels (i.e., to exert a vasodilating effect);
• Supply tissues with oxygen.

Mechanism of action

What is the effectiveness of the drug "Vazonit 600"? The reviews say that the active ingredient of this medication is able to improve blood circulation in small vessels and in those places where it is disturbed. This process is due to the improvement in blood fluidity, as well as the expansion of small capillaries.

According to the experts, the fluidity of the blood is increased due to the restoration of the normal form of platelets and erythrocytes, as well as suppression of the adhesion process with the subsequent formation of a thrombus.

How does the Vasonitis drug work? The reviews say that after taking this medication, the level of fibrinogen protein in the blood decreases markedly. By the way, it is the last element that takes part in the process of formation of thrombi, and also enhances fibrinolysis, that is, resolves clotted clots. It should also be noted that the expansion of capillaries improves the circulation of all the tissues concerned.

Features of the drug

What is remarkable about the "Vazonit" (tablets)? The reviews report that by supplying tissues with oxygen, this drug contributes to a significant improvement in the cellular metabolism, as well as the restoration of normal functioning of all internal organs and systems.

As is well known, with lowering the patency of the arteries at the periphery, which arises, for example, in the development of atherosclerosis, improving blood circulation in the affected limbs helps to make the patient easier to walk. Also, the spasms of the calf muscles diminish or disappear altogether.

Kinetics

Is the drug "Vazonit" absorbed into the bloodstream? Instructions, reviews argue that after taking the pill inside its active element is gradually and almost completely absorbed from the digestive tract. In doing so, it provides long-term action of the drug.

After absorption, pentoxifylline undergoes a metabolism in the liver, resulting in the formation of pharmacologically active metabolic products. Their greatest concentration in the systemic circulation is achieved after 4 hours, and the curative effect persists for half a day.

This drug is excreted in the urine as exchange products. Also some part of the medicine can be allocated with mother's milk and feces.

In severe violations in the work of the kidney pentoxifylline is slower. This requires lowering the doses of the drug. If the liver function is impaired, the patient's bioavailability increases, which also requires a revision of the standard therapy regimen.

Indications

At what diseases is the most effective drug "Vazonit"? The patients' comments state that this remedy has helped them well under the following conditions:

• Disturbed blood circulation of the brain, associated with its insufficient supply of O ₂ , as well as changes in the patency of the vessels;
• Violations of the arterial blood circulation associated with atherosclerosis, inflammation of the walls of blood vessels, diabetes mellitus, Raynaud's disease, as well as against gangrene and frostbite;
• In the combined therapy of the consequences of ischemic stroke, which are accompanied by a violation of concentration and intelligence;
• Violations of venous circulation against thrombophlebitis, varicose veins and the formation of trophic ulcers;
• Metabolic-dystrophic disorders from the brain;
• Hearing and visual impairments associated with impaired blood circulation in these areas.

Prohibitions for admission

In what cases is it forbidden to take the medicine "Vazonit"? Reviews speak of the following contraindications:

• Myocardial infarction in an acute period;
• Disturbed vision, which is associated with hemorrhages;
• Hemorrhages in the brain (that is, with hemorrhagic stroke);
• Any significant bleeding;
• Pregnancy and lactation;
• Underage age;
• Individual intolerance to the components of the drug.

Careful appointment

With special care, these pills are prescribed for atherosclerosis of the blood vessels of the heart and brain, decreased blood pressure, impaired cardiac rhythm, circulatory, renal and hepatic disorders, postoperative period, gastric ulcer, increased bleeding, and also in old age.

Vazonit tablets: instructions for use

Experts say that this drug is highly effective only if it was taken on the advice of a doctor or by instructions. According to the latter, the medicine should be consumed 600 mg twice a day after meals, washed down with water and not chewed.

To individual patients, the dosage of the medication, as well as the duration of its administration, are selected individually.

Now you know how to take the medicine "Vazonit". How long should I drink with thrombangiite? Reviews say that the duration of therapy, as well as the dosing regimen for this disease is established by the doctor individually, depending on the clinic and the resulting therapeutic effect.

Side reactions

Does the drug "Vazonit" cause undesirable consequences? The reviews say that this medication contributes to the appearance of many side effects from internal organs and systems. Let's consider the most frequently manifested right now.

• Severe dizziness, headache, fainting, seizures, drowsiness, meningitis, insomnia;
• Increased heart rate, heart pain, heart rhythm disturbances, decreased blood pressure;
• Loss of fields of peripheral vision, violation of visual acuity;
• Pain in the right hypochondrium, transitory violations in the liver, exacerbation of chronic diseases of the gallbladder and ducts;
• Decreased appetite, nausea, dry mouth, constipation, stomach pain, vomiting, diarrhea;
• Increased bleeding, nasal bleeding, bleeding from the gums and internal organs, reducing the content of cellular elements in the blood, anemia;
• Blood rushes to the upper half of the trunk, fragility of the nail plates, swelling.

One can not help saying that the drug in question often causes an allergy, manifested as a Quincke edema, hives, itching and skin rashes. It is also possible to develop anaphylactic shock.

An overdose of the drug

Is an overdose possible with the drug "Vazonit"? Reviews (analogues of this medication are indicated below) state that if the medication is not taken correctly, the symptoms of an overdose appear quickly enough. The patient has a sharp drop in blood pressure, and also notes nausea, palpitations, shortness of breath, weakness, a sense of lack of air, redness of the half of the trunk and chills. In rare cases, this condition ends with seizures and loss of consciousness. If the patient has ulcerative lesions of the gastrointestinal tract or trophic ulcers, then bleeding is possible.

In case of an overdose, the agent should immediately call an ambulance. Prior to the arrival of a doctor, it is necessary to wash the stomach, and also to drink enterosorbents.

Interaction

The drug in question interacts with many drugs. In particular, it enhances the effect of the following drugs:

• Suppressing blood coagulability (ie, indirect and direct anticoagulants);
• Lowering blood pressure;
• Valproic acid (that is, drugs with an anticonvulsant effect);
• Antibiotic drugs belonging to the group of cephalosporins;
• Funds intended for the treatment of diabetes mellitus.

It should also be noted that with the simultaneous reception with "Theophylline" it is often an overdose of the latter.

In parallel with "Cimetidine", the risk of overdose of "Vazonite" increases.

Special Information

People with severe renal impairment when taking Vazonita should be under regular medical supervision.

In case of a hemorrhage in the retina, the eye should immediately stop treatment.

The therapy under consideration should be performed under the constant control of blood pressure. In patients with unstable and low blood pressure, the dosage should be reduced.

In people with diabetes who take hypoglycemic drugs, taking "Vazonite" in large doses can provoke hypoglycemia.

In the case of simultaneous use of this drug and anticoagulants, it is required to constantly monitor blood coagulability.

For patients who have recently undergone surgery, systematic monitoring of hematocrit and hemoglobin is necessary.

In elderly people, a dose reduction may be required.

Tobacco smoking reduces the therapeutic effectiveness of the drug in question.

During therapy, it is highly recommended not to drink alcohol.

Because of the possible occurrence of severe dizziness, patients are advised to take special care when driving vehicles.

Similar drugs

Analogues of drugs called drugs belonging to different groups, but used to treat the same diseases. The analogue of the drug "Vazonit" is "Xanthinal nicotinate, and also" Tiokol "and" Complamine ". These drugs improve peripheral circulation, including in the organs of vision and the brain area. They also increase the delivery and assimilation of O ₂ brain cells and reduce the aggregation of platelets.

As for the synonyms of the medicine in question, they are referred to as "Pentoxifylline", "Flexital", "Trental", "Agapurin", "Latren" and others.

Medicinal preparation "Vazonit": feedback from the host

There are a lot of reports about the medication in question. In their majority they are positive. According to those who took this medicine, "Vazonit" is ideally suited for the complex treatment of various diseases associated with impaired peripheral circulation. After taking such pills, the condition of the patients improves noticeably. However, experts argue that all vascular diseases can be treated with great difficulty. They require a long-term complex therapy under the constant supervision of a doctor.

The positive aspects of this drug include its relatively low cost. Patients claim that such an effective drug can be purchased for only 250-350 rubles.

There are also negative reviews about the medication in question. As a rule, they are associated with side effects that arise against the background of its reception. In addition, with improper administration of the medication, serious symptoms of overdose may appear in the patient. Therefore, the preparation "Vasonitis" should be prescribed only by an experienced doctor, taking into account all contraindications and indications.