The preparation "Kalimin": instructions for use, reviews

Myasthenia gravis is a common disease. It manifests as asthenic bulbar paralysis. It is characterized by pronounced weakness and fast fatigue of the muscles. In the process of the disease, any part of the body can be affected, but the lips, tongue, pharynx and neck are more vulnerable. Such pathology requires professional treatment. One of the claimed and high-quality drugs for the treatment of myasthenia gravis is the medicine "Kalimin". Instructions for use are in the package with tablets.

Structure of the medicine

The agent "Kalimin" is considered an inhibitor of cholinesterase. Tablets are white, slightly convex. They have an oblong shape with small roughnesses. In the middle of the tablet is divided by a strip. The main substance in the composition is pyridostigmine bromide in a dosage of 60 mg. Auxiliary components of the drug are microcrystalline cellulose, corn starch, silicon dioxide, polyvidone, glutamic acid hydrochloride, purified water, magnesium stearate.

The drug is produced in dark vials, 100 tablets each. Despite the fact that the pill "Kalimin" is dispensed without a prescription, the instructions for use must be studied before starting therapy.

The action of "Kalimin" tablets

The drug improves nerve and muscle transmission, increases the motility of the gastrointestinal tract, increases the tone of the bladder, bronchus, the secretion of the endocrine glands. Causes a bradycardia, a weak miosis, a spasm of accommodation. Achievements of the greatest effect in the body should be expected in 2 hours. Bioavailability of the drug is 20%.

Taking the medicine along with the food does not lower the bioavailability, but lengthens the time to achieve the effect by 1.5 hours. The agent does not penetrate the blood-brain barrier. The drug is not primarily connected to plasma. In a certain amount, it is metabolized in the liver, forms non-active metabolites after cleavage. The medicine "Kalimin" is excreted by the kidneys unchanged. Testimonials, evidence, the correct dosage - with all this you should read before starting treatment.

Indications and contraindications

Indication for the use of the drug is myasthenia gravis. Do not prescribe the drug for bronchial asthma and chronic obstructive bronchitis. Obstructive disease of the biliary and urinary tract is also a contraindication. Do not drink tablets during mechanical intestinal obstruction, myotonia. Contraindications to the use of the drug are pregnancy and lactation, age to 18 years. With increased sensitivity to the components of tablets, they should not be taken.

With caution, it is worth using a remedy for people who are prone to allergic reactions. It is necessary to know that under reduced pressure, kidney and heart failure, the drug is prescribed under close supervision of a doctor. During the period of therapy, it is necessary to monitor blood pressure. With caution apply tablets for diabetes, ulcer of the stomach and duodenum, with hyperthyroidism, after surgery on the stomach.

Before the beginning of treatment it is worth to carefully read the contraindications to the use of the "Kalimin". Instructions for use, feedback - all this is important information for patients.

Dosage of the drug

The tablet is taken orally. It is recommended to drink with plenty of liquid. To achieve a quick effect, it is worth using an agent on an empty stomach. At the beginning of the disease you need to drink half or whole pill once or twice a day. In more severe cases of myasthenia gravis, it is prescribed to take one to three tablets two or four times a day. The maximum allowable dose for taking a day is 12 tablets. The daily rate and duration of treatment are determined by the doctor on an individual basis. The peculiarities of the organism and the progression of the disease are taken into account.

Patients suffering from kidney pathologies should take medication in a reduced dosage. It should be borne in mind that Kalimin can cause side effects. The instructions for use contain information about concomitant therapy of adverse reactions.

Overdose

When an overdose of the drug increases salivary, sweat, tear glands. The patient becomes red, weakness appears, vision is impaired. Unintentional urination and defecation may occur. The patient complains of nausea, vomiting, pressure decreases, bronchospasm increases. In severe cases of overdose, cardiac arrest may occur, leading to death. This condition requires immediate assistance. The antipode for "Kalimin" tablets is "Atropine". It must be administered intravenously in a dose of 2 ml.

Further, depending on the condition of the patient, you can repeat the administration of the drug after three hours. It is recommended to wash the stomach and give an absorbent. The patient should be supervised by medical personnel so that the breathing stops. According to the indications, it is necessary to carry out resuscitation measures. Such severe consequences of an overdose can have a medicine called "Kalimin". Reviews show that bad consequences should be expected only if the medication is used incorrectly.

Interaction with other drug groups

"Atropine" reduces the effect of the drug "Kalimin", but does not affect the skeletal muscles. Pyridostigmine bromide, which is part of the tablets, enhances the action of "Morphine" and barbiturates. The drug is completely incompatible with ethanol. Reduce the pronounced effect of the drug "Quinidine", ganglion blockers, antidepressants, antiepileptic and anti-Parkinsonics.

When pregnancy and breast-feeding is not recommended to prescribe the drug. In the last months of pregnancy, he can cause early birth. When feeding, the substance penetrates into the milk, which can cause poisoning in the newborn with the drug "Kalimin". Instructions for use must be studied in order to avoid unpleasant consequences of therapy.

Reviews about the drug

Patients who suffer from myasthenia graver, respond positively about the drug "Kalimin." Instruction for use will acquaint the patient with contraindications and indications in an accessible form. Tablets in a short time have a positive therapeutic effect, the patients note. The drug has an affordable price and good quality.

The drug is not addictive and is most often tolerated fairly well. However, cases of severe adverse events are known.