The drug "Papaverin". The instruction will help in applying

Among the many drugs that have been trusted for many years in patients, there is such a medicine as "Papaverin." The instruction describes in detail all the indications and doses of the use of this alkaloid. In nature, this substance is contained in opium. Recently, it is most often produced synthetically. This substance is a crystalline powder, sparingly soluble in alcohol, slowly soluble in water. The powder has a slightly bitter taste. The aqueous solution of the substance is sterilized for 0.5 hours at a temperature of 100 ° C.

The drug "Papaverin" refers to myotropic antispasmodics. It reduces contractile activity and reduces the tone of smooth muscles, has an antispasmodic and vasodilating action. This drug is used as an antispasmodic agent in case of spasms of smooth muscles (with cholecystitis, pilorospasm, spastic colitis, spasms of the urinary tract), peripheral vessels, bronchi, cerebral vessels. Until recently, the remedy was often used to prevent attacks of angina pectoris. Taking the medicine "Papaverin", the instruction to which contains information about its positive properties, it should be remembered that in high doses it inhibits intracardiac conduction, reduces the excitability of the heart muscle. The drug lowers blood pressure.

Although doctors often prescribe the drug "Papaverin" to patients, the instruction does not say that the mechanism of its action on the human body is not yet fully understood. This substance is an inhibitor of phosphodiesterase, an enzyme that causes intracellular accumulation of cyclic adenosine monophosphate. Its accumulation leads to a decrease in the contractility of the musculature and its relaxation in spastic conditions.

Often, in conjunction with promedolom appoint a drug "Papaverin", the instruction to which allows you to use it in combination with other antispasmodic and analgesic drugs. Such therapy is performed to eliminate attacks of angina pectoris. It is also often prescribed this drug in combination with platyphylline, phenobarbital and other substances.

The drug "Papaverin" is released in tablets (0.04 g) in packages of 10 pcs., In ampoules with 1 and 2% solution of 2 ml, in rectal suppositories of 0.2 g. The active substance in tablets, easily penetrating through the histogematic Barriers, quickly absorbed into the digestive tract. The drug is excreted by the kidneys. The half-life is from half an hour to 2 hours. Up to 60% of the solution of this substance is released in the form of various compounds (with glucuronic acid, phenolic).

The drug "Papaverin", the instruction to which clearly describes in which doses to take the drug to patients of different ages, requires strict observance of these norms. Excessive dosage often leads to serious consequences. Adults per day are usually prescribed 3-4 times a drug intake of 1 tablet (0.04 g). Assign pills to children, depending on the number of years, for a 3-4-time intake in such dosages:

- 0,5-2 years: 0,25-0,5 tablets;

- 3-4: 0.5-1 table;

- 5-6: 1 table;

- 7-9: 1.5 tablets;

- 10-14: 1,5-2 tab.

Intramuscularly and under the skin solution injected to 1-2 ml (1; 2%). Cautiously and very slowly injected 2% solution inside the vein (1-2 ml), since the drug can cause the onset of atrioventricular block, ventricular fibrillation and ventricular extrasystoles. In the form of suppositories, the agent uses 0.003-0.03 g per dose (dosage depends on age). Candles are used after enema or bowel movement.

Contraindicated take the drug with hypersensitivity to it, arterial hypotension, violation of atrioventricular conductivity. Do not take the drug without consulting a doctor. Efficacy or safety of it during lactation and pregnancy is not established. Therefore, the medicine "Papaverin", the indications for the use of which during this period are not vital, it is better not to use it. During treatment, alcohol is not allowed.