The drug "Armadine": instructions for use (injections)

To date, in modern medical practice, the drug "Armadin" is increasingly found. Instructions for use (injections - the form we are considering) of this tool is quite difficult to master, and many prefer to look for more accessible data.

Next, we'll look at how this tool works, what are its advantages and disadvantages, and how to use it correctly.

Pharmacodynamics

"Armadine" is a specialized inhibitor of free-radical processes, it is a membrane protector. In the process of taking this drug is nootropic, antihypoxic, stress-protective and anxiolytic effects, the drug also significantly increases the body's resistance to the influence of various damaging factors and to pathological oxygen-dependent conditions.

To the preparation "Armadin" the instruction on the application (nyxes) marks the fact that with the help of it the blood supply of the brain and brain metabolism improve, the aggregation of thrombocytes decreases, the rheological properties of the blood improve, as well as its microcirculation. At the same time, doctors often supplement this list with the fact that the remedy is prescribed due to the stabilization of the membrane structures of blood cells during hemolysis, when it is taken, endogenous intoxication and enzymatic toxemia also decrease in case of acute pancreatitis.

How does he work?

The operation mechanism (injections), contra-indications and other aspects describe in detail the mechanism of action of the "Armadine" device. The work of this product is due to its membrane-protective and antioxidant effects. During the reception, the activity of superoxide dismutase increases, LPO is inhibited, the "lipid-protein" ratio increases, and the viscosity of the membrane decreases, hence its fluidity increases. In addition, the use of this drug allows the modulation of the activity of various membrane-bound enzymes and receptor complexes, which positively affects their ability to bind to ligands and allows preserving the structural and functional organization of biomembranes.

Separate attention should be paid to the fact that the instructions for use (nyxes) to the "Armadine" preparation describe the main features of its action, and also indicate normalization of metabolic processes in ischemic myocardium, reduction of the necrosis zone, recovery and subsequent improvement of electrical activity and myocardial contractility, and Also a significant increase in coronary blood flow in the ischemic zone. Admission of this agent contributes to the long-term preservation of retinal ganglion cells, as well as optic nerve fibers in the case of progressive neuropathy, which can result in hypoxia and chronic ischemia.

Among additional effects, special attention should be paid to improving the functional activity of the optic nerve and retina, which increases the visual acuity of a person.

Pharmacokinetics

When administered intramuscularly, the drug is determined in the blood plasma for four hours. The total time to reach C _max is from about 0.45 to 0.5 hours.

It is worth noting the fact that the drug quickly starts to move from the bloodstream into various tissues and organs, and then is excreted from the body. This happens in the urine, most of the time in the glucuron-conjugated form and in small amounts, and in an unchanged form. This is the peculiarity of how the drug "Armadine" is injected (injections). The composition of this agent includes ethylmethylhydroxypyridine succinate, which is rapidly absorbed into the gastrointestinal tract.

Ethyl methylhydroxypyridine succinate in the human body begins to be intensively metabolized with the further reduction of its glucuronoconjugate. In the majority of cases approximately 0.3% of the unchanged drug is excreted in about 12 hours with urine, while 50% is already in the form of glucuronoconjugate.

The maximum intensity of the eilmethylhydroxypyridine succinate together with its glucuronoconjugate is excreted during the first four hours after using this preparation. Quite often about the "Armadine" (injections) the doctors' reviews include the data that urinary excretion rates of this element and its metabolites differ in significant individual variability.

When is it taken?

As you know, this product is available in two forms: injections and standard tablets. Each option is used in different cases, so you need to understand correctly when and which one is best to choose. In the majority of cases, doctors who prescribe this remedy, independently indicate the form of its reception.

Injections

To the preparation "Armadine" (injections) the instruction indicates that in this form its use is shown in the following cases:

• Presence of acute disorders in the cerebral circulation;
• The consequences of various craniocerebral injuries;
• cardiopsychoneurosis;
• encephalopathy;
• Presence of any anxiety disorders during the course of neurotic-like and neurotic states;
• Small cognitive impairment in atherosclerotic origin;
• The emergence of primary open-angle glaucoma of various stages (in this case, to the preparation "Armadine" (injections) the instruction indicates that its use is shown as an element of complex therapy);
• Withdrawal of the withdrawal syndrome in case of alcoholism, if neurocirculatory and neurosis-like disorders prevail.

Pills

This form of medication has slightly different indications for use:

• Neurotic-like or neurotic states with various anxiety symptoms;
• Consequences of acute disturbance in the cerebral circulation;
• cardiopsychoneurosis;
• Encephalopathy of different genesis;
• Light cognitive disorders of different genesis;
• Memory impairment or the presence of intellectual insufficiency in people in old age;
• Small craniocerebral trauma and their consequences;
• Absinental syndrome in the process of alcoholism with the presence of vegetative-vascular or neurosis-like disorders;
• All kinds of asthenic conditions or the influence of extreme factors;
• The state of subsequently developed intoxication by various antipsychotropic agents;
• IHD;
• Cardiology in the complex of ongoing therapy;
• Dyslipoproteinemia of atherogenic type.

How do I make injections?

So, the doctor prescribed the drug "Armadine". Injections intramuscularly or intravenously can be administered by drip or jet. The doses in each case are selected exclusively using an individual approach, as a result of which qualified physicians should be engaged in this.

When using the infusion method of administration, this preparation should be diluted in a physiological solution of sodium chloride. It is recommended to begin treatment of adults with a dose of 50 to 100 mg, which is administered from one to three times a day. In the future, volumes may increase, as indicated by the instruction "Armadine" (injections). Ampoules contain the drug itself, which must be slowly injected for 5-7 minutes in a jet, while "Armadine" is dripped at a speed of about 40-60 drops every minute. The maximum possible daily dose of this medication is 800 mg.

In the presence of any acute disorders in the cerebral circulation, the drug is prescribed as part of complex therapy for 2-4 days intravenously drip adult 200-300 mg once every 24 hours, after which it is already used as intramuscular injections at doses of 100 mg per day Three times a day. In this case, the duration of treatment can be up to fourteen days.

If it is a question of craniocerebral trauma or their various consequences, this drug is used for 10-15 days by intravenous injection in a volume of 200 to 500 mg 2-4 times a day.

The drug "Armadine" (injections) is prescribed for discirculatory encephalopathy in the stage of decompensation, where it is used intravenously by dropwise administration in doses of 100 mg two or three times a day for 14 days, after which it is already used intramuscularly for two weeks for 100 Mg twice a day. In addition, the drug is used in the course of the course of prevention of dyscirculatory encephalopathy in adults by intramuscular injection of 100 mg twice a day for 10 to 14 days.

With myocardial infarction

If the patient underwent an acute myocardial infarction, then the drug "Armadine" (injections) intramuscularly or intravenously administered for 14 days against a background of standard therapy, including all kinds of thrombolytics, ACE inhibitors, sympomatic, antiaggregant and anticoagulant agents, as well as Nitrates. During the first five days it is used to achieve the maximum possible effect, while it is recommended to use the drug intravenously. Within the next nine days, the possibility of intramuscular injection is already envisaged.

Intravenous administration is carried out by means of drip infusion, and at the same time, the drug should be administered slowly in order to avoid the risk of side effects. The drug is used in a 0.9% solution of sodium chloride or in a 5% solution of dextrose in a volume of about 100-150 ml. Introduction is carried out for 30-90 minutes. If necessary, the drug "Armadine" (injections) is prescribed by means of a slow blasting for at least 5 minutes.

The agent should be administered three times a day every 8 hours. The daily therapeutic dose in this case is from 6 to 9 mg per kilogram of body weight of the patient, and a single dose is, respectively, 2-3 mg / kg of body weight. The maximum possible daily dose is 800 mg, while one-time recommended to enter no more than 250 mg.

Other diseases

In the presence of absent alcoholic syndrome, the drug is administered in a dose of 100-200 mg intramuscularly from two to three times a day, or it can be dripped intravenously 1-2 times a day for 5-7 days, as indicated in the Armadine tool Application (nyxes). The doctors' comments also suggest that if there is acute intoxication with antipsychotic drugs, the medication should be administered exclusively intravenously at doses of 50 to 300 mg daily for 7-14 days.

In the presence of any purulent-inflammatory processes in the abdominal cavity, the agent is prescribed on the first day as a preoperative, and then - as a post-operative therapy. In this case, the dosage will directly depend on the severity and form of the disease, the clinical course and the prevalence of the process. It should be noted that if it is necessary to cancel this drug, it should be carried out gradually, and only after a stable positive clinical and laboratory effect is achieved.

If acute edematous pancreatitis occurs, the medication is used in doses of 100 mg three times a day intravenously drip or intramuscularly, depending on the doctor's indications.

special instructions

Special attention should be paid to the prescription of the drug to patients with a history of allergic history. In certain cases, in people with asthma, if there is excessive sensitivity to sulfates, development of severe hypersensitivity reactions can occur. After the parenteral administration has been completed , it is recommended to continue using this medication in the form of tablets to maintain the effect achieved.

There are no strictly controlled clinical trials regarding the safety of this drug when taken during breastfeeding or pregnancy, and therefore doctors are not recommended for its use during this period. Similarly, studies have not been conducted on the safety of the medication in the course of its use for the treatment of children, and for this reason it is also not recommended for their use, even if the above diseases occur.

Among other things, it is worth noting that in the process of treatment, extreme care must be taken when driving vehicles or various mechanisms, as indicated in the instruction manual for the Armadin tool (injections). Analogues of this drug are often characterized by similar side effects. These, for example, such as "Mexidol", "Mexicor", "Mexican", "Neurox".

Against the background of prolonged use of the described medication, a number of side effects may appear, including weakness, flatulence or peripheral edema. With intravenous administration (especially for jet), a metallic taste in the mouth, a sore throat, a sensation of fever throughout the body, palpitations, tachycardia, facial hyperemia, and a number of other effects may appear, due to the too high rate of administration of the drug "Armadine" ( Injections). Reviews say that these consequences are of a short-term nature.