The drug "Aprotex": instructions for use, description, reviews

Hemostatic or so-called haemostatic agents are particularly often used in surgical practice. Thanks to such drugs, the doctor can stop the bleeding in time and thereby save the life of his patient.

Today among haemostatic drugs such a drug as "Aprotex" is especially popular. Instructions for use, analogs, as well as side effects and contraindications for this drug will be presented below.

Description, composition, packaging and form of release

The drug "Aprotex", the instruction of which is contained in a cardboard package, goes on sale as a white powder-lyophilizate, which is intended for preparation of an intravenous solution.

Active part of this medication is aprotinin. As for the additional ingredients, they use lactose and sodium hydroxide as their ingredients.

You can buy the agent in 50 ml or 10 ml vials. One pack of cardboard usually contains 5, 1 or 10 bottles.

Pharmacological properties

What is Aprotex? Instructions for use suggest that this is not only a hemostatic, but also an antifibrinolytic and anti-proteolytic agent.

The medicament in question is capable of inactivating proteinases of plasma of tissues and blood cells, which play a very important role during pathophysiological processes.

The effectiveness of this tool is due to its ability to block the activation of plasminogen and inactivate the proteolytic effect of plasmin.

The antiprotease effect of "Aprotex" has a positive effect on various pancreatic lesions. Also, this drug slows down fibrinolysis, reduces fibrinolytic activity of the blood and has a haemostatic effect in coagulopathies.

The ability of a drug to block a kallikrein-kinin system is particularly often used in angioedema, as well as in the therapy and prevention of shock conditions.

Kinetic features

What are the kinetic characteristics of the drug Aprotex? Instruction for use informs that after its intravenous administration, it is quickly distributed in the extracellular space, and also accumulates in the liver for a short time.

Inactivation of the drug occurs in the gastrointestinal tract. In this case, the drug is partially destroyed in the kidneys and liver. This process is carried out under the action of renal lysosomal enzymes.

The withdrawal of the active substance of the drug occurs within six hours.

Indication for the use of powder-lyophilizate

In what cases do you use the drug Aprotex? Instruction for use informs that this preparation is especially effective when:

• Pancreatic necrosis;
• Acute pancreatitis, the prevention of postoperative pancreatitis, exacerbation of chronic pancreatitis;
• Complications of thrombolytic therapy;
• Hyperfibrinolytic bleeding of posttraumatic or postoperative origin (including surgical intervention on the lung and prostate gland);
• Bleeding before, during and after labor (including amniotic fluid in embolism);
• Operations on the open heart, when there is a need for the use of devices of artificial circulation ;
• Polymeneure;
• Postoperative parotitis;
• Treatment and prevention of various forms of shock (eg, endotoxic, hemolytic, traumatic).

Contraindications to the use of the product

When should I not prescribe the lyophilizate "Aprotex"? The instruction for use says that there are not very many contraindications to this drug. It should not be used when:

• DIC-syndrome;
• Individual hypersensitivity to aprotinin;
• Pregnancy (in the first and third trimesters);
• Breastfeeding.

With caution, this medication should be used in cardiopulmonary bypass surgery, deep hypothermia, the presence of allergic reactions (in the anamnesis), the patient's presence on the artificial circulation.

It should also be noted that during pregnancy this drug is used only in the second trimester (according to vital indications).

If it is necessary to prescribe a medicament during the lactation period, then during the period of breastfeeding it should be stopped.

Aprotex powder: instructions for use

Before using the drug, the contents of the vial should be dissolved in 2 ml or 20 ml of isotonic sodium chloride solution (depending on the dosage).

So how should I use Aprotex? The instruction, the description of the medicine inform about the following schemes:

• In the prophylactic purposes of postoperative pancreatitis, the daily dosage of this drug is 200 thousand AtrE (jet, intravenously).
• In acute pancreatitis, the medication is first prescribed in the amount of 200-300 thousand ATPE (slowly struino, intravenously), and then drip intravenously - in the same dosage. Pour the drug should be before the normalization of laboratory indicators and clinic of the disease.
• With bleeding of various origins, the initial dosage of the drug is 300,000 ATPE, and the subsequent dosage is 140,000 ATRE. The medication is injected intravenously every 4 hours until the hemostasis normalizes.
• For the prevention of embolism (fat), the initial dose of the drug is 200 thousand ATPE, and then every day in the same amount slowly intravenously. Children with violations of hemostasis drug is prescribed in the amount of 15 thousand ATPE per 1 kg of body weight.
• The initial dose of the drug in shock states is 200-300 thousand ATPE. After this every 4 hours, maintenance doses (intravenous, jet) are used for 140 thousand ATPE.
• With topical application of the drug, when there is slight but prolonged bleeding, the usual napkin is impregnated with a solution of Aprotex in the amount of 75,000 ATPE, and then applied to the lesion focus.

How should I inject with Aprotex? Instructions for use (in ampoules the medication can be stored for two years) reports that the agent should be administered in the patient's reclining position, slowly intravenously striated or drip.

Adverse Reactions

After the administration of the medication, the following undesirable effects can be noted in the patient:

• Psychotic reactions, confusion or hallucinations;
• Urticaria, conjunctivitis, pruritus, anaphylactic reactions, or rhinitis;
• Tachycardia, lowering blood pressure;
• Nausea (eg, with rapid administration) or vomiting;
• Myalgia, bronchospasm;
• Thrombophlebitis at the injection site (especially with prolonged administration of the drug).

Cost and analogues of "Aprotex"

Replace the drug under consideration by means such as "Vero-narcup", "Gordoks", "Aeros", "Contrikal", "Ingitril", "Trasilol 500000", "Ingiprol", "Trascolan" and others.

You can buy this medicine at a price of 450-570 rubles per one packing No. 10.

Reviews

Many patients with chronic pancreatitis report that this medication is very effective. This tool quickly helps to stop the exacerbation and normalize the general condition of the patient.

Comparing this solution with Gordex, experts point out that Aprotex is more effective. They also report that this remedy is not intended for self-administration. Its introduction requires special skills, otherwise the patient may experience numerous undesirable effects.