Propranolol: analogues, instructions for use, description and reviews

"Propranolol" is a drug that is part of a group of selective adrenoblockers. The drug has antianginal action, antiarrhythmic and hypotensive. The drug is prescribed for the purpose of the treatment of IHD, thyrotoxicosis, hypertension. The medication is effective in neurocirculatory dystonia, migraine. It is used in the implementation of therapy for heart failure, angina pectoris. The drug benefits the body with myocardial infarction. They treat arrhythmia and cardiomyopathy hypertrophic. When Propranolol is not suitable for a patient, analogues are considered by a specialist, a medication is prescribed, which is optimal for the patient.

Form of issue

You can buy a drug of two types - the drug "Propranolol" and the drug "Propranolol Nycomed". These are the same drugs that are produced by different manufacturers in tablets.

Components of the medicine

The drug is made on the basis of the active substance propranolol. The dose of the main component can be different - 10, 40, 80, 160 mg in each tablet.

Auxiliary ingredients in the production of tablets are used different and depend on the manufacturers. To know exactly what the medicine consists of, you must always read the instructions before using it.

Therapeutic effect of the drug

Displays the ability to block beta-adrenergic receptors of the drug "Propranolol" instructions for use. Analogues have on the body a similar action. Tablets affect the receptors of the walls of the vessels beta 1 and 2. The inhibitory effect on these receptors leads to the relaxation of the walls of the vessels, thereby eliminating many problems - high blood pressure, increased heart need for oxygen, poor supply of nutrients and oxygen to tissues and organs.

Antiarrhythmic effect of the drug contributes to the appearance of positive changes in the body, such as normalization of the automatism of the sinus node, a decrease in the conductivity of the atrioventricular node, the elimination of increased excitability of the cells that make up the myocardium. Thanks to "Propranolol" normal heart work is restored, there is no reaction to external stimuli, which can negatively affect its rhythm.

"Propranolol" analogs contribute to the development of an antianginal effect, which is manifested by an improvement in the state of the heart muscle, a decrease in the amount of oxygen necessary for its work. This means that the heart requires less oxygen to reduce, and the frequency of these reductions also decreases.

The hypotensive effect is based on increasing the lumen of the vessels and relaxing their walls. The use of a single dose of tablets leads to a decrease in blood pressure, the effect is preserved for at least 20 hours, about a day. A persistent hypotensive effect occurs after two weeks of regular use of the tablets. The drug is not suitable for arresting conditions accompanied by a sharp increase in pressure, it is indicated for prolonged therapy in hypertension.

Long-term use of the drug leads to the development of cardioprotective action. Evidence of a decrease in the likelihood of recurrence of myocardial infarction after such therapy with the drug "Propranolol" reviews, instruction. Significantly reduced and the risk of sudden death. It is known that the drug has a positive effect with increased intraocular pressure.

Pharmacokinetics

After entering the body, the absorption of the main part of the drug (about 90%) takes place, while the bioavailability index is insignificant. The connection with proteins corresponds to 93%. From the body, the medicine is removed with urine, into which metabolites enter. Invariable species has not more than one percent of the drug.

Indications

Propranolol, an analogous instruction allows you to prescribe for the treatment of certain conditions and diseases. They treat hypertension portal and arterial, myocardial dystrophy, thyrotoxicosis. The medication helps to alleviate the condition with narrowed aortic lumen, essential tremor, panic attacks, can be used as a remedy for prophylactic purposes with migraine. Tablets are suitable for therapy in neurocirculatory dystonia, myocardial infarction, extrasystole. The drug is prescribed to patients with mitral valve prolapse. Indications include supraventricular tachycardia and sinus. The purpose of the remedy is with abstinence syndrome, angina pectoris, akathisia due to the use of neuroleptics. The medication is prescribed to patients with pheochromocytoma for complex therapy. The drug is used in case of weakness of labor activity, after the onset of menopause for elimination of its negative manifestations.

Contraindications

There are some contraindications for the drug "Propranolol". Analogues can be selected in cases where this medicine is not suitable. Contraindications include:

• Intolerance of the components of the agent;
• Cardiogenic shock;
• Bradycardia, in which the number of cardiac contractions per minute is 55 bpm;
• Metabolic acidosis;
• Heart failure of a chronic or acute form;
• Vasomotor rhinitis;
• Sinoatrial block, atrioventricular (2nd, 3rd degree);
• Angina of Prinzmetal ;
• Decreased blood pressure;
• Use of insulin;
• Syndrome, accompanied by weakness of the sinus node;
• The presence of a period during which prolonged fasting was present;
• Problems with peripheral circulation (stage of decompensation);
• Previously transmitted instructive diseases in which the respiratory tract, asthma, bronchospasm are affected.

There are also such conditions in which caution is required. In the following cases, you can choose analogues, synonyms instead of the preparation "Propranolol":

• Myasthenia gravis;
• Diabetes mellitus (stages of decompensation, subcompensation);
• Insufficiency of the heart muscle (decompensated), liver, kidneys;
• Colitis spastic;
• Depressive conditions;
• Atrioventricular block (first degree);
• psoriasis;
• Increased thyroid function;
• Chronic bronchitis;
• Low blood sugar;
• emphysema;
• elderly age;
• Period of pregnancy, breast-feeding.

Treatment with drug

Patients with hypertension should take a drug twice a day in a dose of 40 mg per dose. Its increase is possible within 14-28 days. If necessary, you can drink tablets daily at a dosage of 80 to 160 mg. The frequency of the medication is the same.

With tachyarrhythmias, adult patients drink three or four times daily from 10 to 30 mg per each dose of Propranolol. Analogues can be used if this drug is not suitable. For small patients with the same problem, a drug is prescribed in the amount of 0.2 to 0.4 mg per kilogram of body weight. The frequency of application of the remedy is also three to four times a day.

For preventive purposes, patients who have had angina pectoris are prescribed four daily doses of this medication. A single dose is 20 mg. Its increase is possible for seven days. 40 mg of the drug is taken with the same frequency, 80 mg - a little less often (twice).

After myocardial infarction, prevention is required. It can be performed with the medication Propranolol. The size of a suitable single dose is 40 mg, the drug intake per day should be three. Increase the dose of the drug to a maximum of 80 mg.

When migraine requires the implementation of preventive measures using 40 mg of medicines twice a day. It is required to increase the dose to 80 mg, the medications per day can be two or three, and in children - three or four. Calculation of the dose for small patients is performed taking into account their weight, for each kilogram - from 1.5 to 2 mg.

Thyrotoxicosis is a disease in which the drug is prescribed from 10 mg, but not more than 40 for taking three or four times a day.

If you plan to perform pheochromocytoma therapy, the drug is combined with alpha-blockers.

Adverse events

It is necessary to pay attention to the instructions for use which determine the side effects of the Propranolol medication. Analogues, reviews are also no less important information that influences the choice of medications for treatment. In order to minimize the risk of developing negative reactions of the body, we must carefully read the instructions, it will be useful to review the reviews.

Medication with improper use can harm the cardiovascular system, cause disruption in the work of the central nervous system, the endocrine system. Possible negative manifestations of the digestive tract, the condition of mucous membranes and skin can be disturbed. Among the side effects indicated in the manual are problems with the respiratory system. There may be other side effects.

Analogues, price

Before purchasing the drug "Propranolol", analogues, the price is often studied by patients. You can buy tablets for 16-75 rubles. The price is determined by the number of tablets in the package. You can replace the drug with "Propranolobene", with medications "Obsidan" or "Anaprilin". It is also possible to make treatment with Inderal LA, Inderal.

When familiarized with the drug "Propranolol" instructions for use, price, analogs give important information that allows you to make the most correct decision when choosing medicines and the way of treatment.

Reviews

Reviews are mostly positive. They report that treatment with the drug is often effective. In addition, many are satisfied with the low price of the medicine. "Propranolol" can maintain blood pressure at a normal level, quickly get rid of rapid heart rate. The medication reduces the manifestations of heart diseases, relieves a person of excitement. Negative responses people usually leave because of serious side effects that may occur during therapy. Sometimes there is a strong weakness, problems with sleep, dreams are nightmares.