"Passage": instructions for use. "Passage": indications for use, reviews, analogues

Vomiting refers to a reflex eruption through the mouth (sometimes through the nose) of the contents of the stomach or duodenum. This phenomenon is due to the contraction of the musculature of the press.

In the process of vomiting, the output part of the stomach is closed, and his body is completely relaxed. At the same time, the entrance to it opens, as well as the esophagus and the oral cavity.

The entire described reflex act is controlled by the vomiting center, which is located in the medulla oblongata. Such a person's condition can be observed with infectious diseases, poisoning, accumulation of toxins in the blood, irritation of the peritoneum, peptic ulcer, gastritis, pregnant women, etc.

Episodic vomiting is not accompanied by bleeding, nor does it endanger the patient's life. But if such a process is repeated very often, it can lead to serious consequences. These include dehydration and electrolyte imbalance, which can lead to death. This is why when you get periodic vomiting, you should always contact the doctor. It is also required to take special drugs that help suppress the reflex.

The most popular antiemetics include such a drug as "Passage". Indications for use and instructions for this medication will be provided below.

Form of release, packaging and composition

In what form is the medicament "Passagex" produced? Consumer feedback reports that such a product is sold in the form of chewable tablets. They are packed in contour squares and cardboard pack, respectively.

The active ingredient of the medicine in question is domperidone. As auxiliary substances, aspartame, xylitol, lactitol, magnesium stearate and menthol are used.

Pharmacological characteristics

Instructions for use ("Passazyks" should be used only on indications) informs that the agent under consideration is an antiemetic drug. It is the central antagonist of dopamine receptors.

This medication is able to increase the duration of peristaltic contractions in the antral part of the stomach and duodenum. It also speeds up the emptying of the contents of the digestive tract (with the slowing of this process), eliminates nausea and vomiting, increases the tone of the esophageal sphincter (in the lower part).

It should also be noted that domperidone weakly penetrates the blood-brain barrier. This is why the use of this drug is rarely accompanied by extrapyramidal reactions.

It should also be noted that domperidone is able to stimulate the release of prolactin from the pituitary gland.

The action (antiemetic) of the drug in question is due to a combination of gastrokinetic influence and antagonism to dopamine in the chemoreceptor trigger zone. It should also be said that this substance does not have a detrimental effect on gastric secretion.

Kinetic properties

What are the kinetic characteristics of the drug "Passagex"? Instructions for use indicate that after taking a chewable tablet, its active ingredient is quickly absorbed into the blood.

Domperidone has a low bioavailability (about 15%). Its maximum concentration is observed after 65 minutes.

Reduced acidity of gastric juice can reduce the absorption of the drug.

According to experts, domperidone is well distributed in various tissues. As for the brain, the concentration of the drug in it is small. The connection with plasma proteins is about 92-93%.

It should also be noted that the drug "Passagex" (tablets) is metabolized in the walls of the liver and intestines. It is excreted through the intestine (about 66%) and kidneys (about 33%).

The half-life of the drug is 7-8 hours. With severe renal failure this interval is longer.

Indications

This medication is prescribed for vomiting and nausea of various origins, including organic and functional diseases, radiation therapy and infections. Also, this remedy can be prescribed for toxemia, morphine intake, diet disorders, the use of "Levodopa", "Apomorphine" and "Bromocriptine."

In what other cases can the medicament "Passagex" be used? Instructions for use indicate that this medication is often prescribed for atony of the gastrointestinal tract (including post-operative), hiccups, radiopaque and endoscopic examinations of the digestive tract. Also, the drug in question is needed to accelerate peristalsis in diagnostic procedures, dyspeptic disorders resulting from delayed gastric emptying, esophagitis and gastroesophageal reflux.

The "Passagex" tablets, the indications for use of which are discussed above, are well manifested in a feeling of overcrowding in the stomach, flatulence, sensation of bloating, gastralgia, heartburn and belching.

Contraindications

When should you not take Passex tablets? Instructions for use, reviews report the following contraindications for the drug in question:

• Hypersensitivity;
• Children under the age of 5 years, as well as babies with a body weight of up to 20 kg;
• Prolactinoma;
• Phenylketonuria.

It should also be noted that this remedy is not prescribed if stimulation of gastric motility can be dangerous (with gastrointestinal bleeding, perforation or mechanical obstruction).

With caution, this drug can be used for renal or hepatic insufficiency, during pregnancy and during lactation.

"Passagex" tablets: instructions for use

Chewable tablets "Passaziks" are recommended to be taken for ¼ hours before eating.

For chronic dyspepsia, adults are prescribed 10 mg of the drug (1 tablet) three times a day. If necessary, the medication can be taken before bedtime.

Children older than 5 years of this drug give 2.5 mg for every 10 kg of weight three times a day and, if necessary, before going to bed.

In subacute and acute conditions (with nausea and vomiting), adult patients are prescribed 20 mg of the drug four times a day and at bedtime. Children older than 5 years are recommended to take 5 mg of medication for every 10 kg of weight four times a day and at bedtime.

In case of renal insufficiency, correction of the dose with a reception frequency of no more than 1-2 times is required throughout the day.

The maximum dosage of medication per day for adults is 80 mg (ie 8 tablets). As for children, it should not be higher than 10 mg for every 10 kg of the child's weight.

Adverse events

Are the side effects of the chewing tablets "Passagex"? Experts say that this tool can cause unwanted effects in the form of:

• Transient spasms of the intestine;
• Extrapyramidal phenomena;
• Increasing the concentration of prolactin in plasma;
• Galactorrhea, dysmenorrhea and gynecomastia;
• Rash and hives.

Signs of an overdose

What are the symptoms of overdose can cause drug "Passage"? The instruction says that such phenomena include drowsiness, disorientation and extrapyramidal reactions.

To treat such conditions it is recommended to take activated charcoal and consult a doctor.

Interaction with other drugs

Simultaneous reception of the medicine "Passagex" with anticholinergics can neutralize the effect of the former.

Combination with antacids reduces its bioavailability.

When a combination of domperidone and drugs inhibiting the isoenzyme CYP3A4 (for example, antibiotics of the macrolide group, antifungal agents of the azole group, antidepressant Nefazodone, HIV protease inhibitors), the patient may have an increase in the concentration of the active substance in the blood.

The medicament in question does not affect the concentration of digoxin and paracetamol in plasma. It can not be ruled out that it can influence the absorption of drugs (simultaneously administered orally) with sustained release of the active ingredient or coated with an enteric coating.

Breastfeeding and pregnancy

The drug "Passazyks" is forbidden to be taken during pregnancy.

In women, the concentration of domperidone in milk is four times lower than in plasma. It is not known whether this has a negative effect on babies. Therefore, if you need to use the medication during breastfeeding, lactation should be discontinued.

"Passagex" tablets: analogues and cost

The cost of the funds in question is about 220-360 rubles. If required, the anti-emetic drug can be replaced by one of such medications as Motilium, Domstal, Kinidril, Avioplant, Doprokin-C, Diskkineton, Emeset, Motinol, E.

It should be recalled that all of the listed facilities may have their own characteristics. Therefore, to use them instead of "Passazaksa" follows only after consulting with the doctor.

Reviews about the drug

Most patients who used the drug in question, speak of its high efficiency. According to consumers, this remedy quickly eliminates the feeling of nausea and prevents the appearance of vomiting.

It should also be noted that this medicine can be taken with other symptoms. For example, it is often used for heaviness in the stomach or bloating. In this case, tablets for chewing are recommended to take one piece three times a day for five days.

The main drawbacks of the drug "Passagex" include side effects that occur against the background of its administration, as well as the presence of various contraindications.