Paglyuferal tablets: instructions for use, analogues and reviews

People suffering from epilepsy should regularly take antiepileptic drugs. They help to prevent the development of seizures, and also improve the overall well-being and condition of the patient.

What exactly drugs should be used by patients with epilepsy should be determined only by an experienced doctor. The most effective and popular anticonvulsant drugs include the drug "Paglyuferal". Instructions for use of this medication will be described below. Also you will learn about the form in which this drug goes on sale, whether it is possible to give it to children, what properties it possesses and so on.

Description, packaging, composition and form

The preparation "Paglyuferal", the instruction for its use is contained in packs of cardboard, goes on sale in the form of white tablets with a facet and a risk.

This product contains active ingredients such as phenobarbital, caffeine sodium benzoate, bromide, calcium gluconate and papaverine hydrochloride. As for the auxiliary substances, they include potato starch and calcium stearate.

You can buy this medication in contour squares and packs of heavy paper, respectively.

It should immediately be noted that on the shelves of pharmacies such a drug can be found in the following names: "Paglyuferal-1", "Paglyuferal-2" and "Paglyuferal-3". Instruction for use informs that the difference between these means lies in the quantitative ratio of phenobarbital (25, 35 and 50 mg respectively).

Pharmacology

What is the drug "Paglyuferal"? Instructions for use (tablets should be prescribed only by an experienced professional) states that this is a combined antiepileptic agent.

According to specialists, phenobarbital is able to interact with the "barbiturate" site of the benzodiazepine-GABA-receptor complex. Due to this, this drug increases the sensitivity of GABA-receptors to GABA, and also opens neuronal channels for the transport of chloride ions, which contributes to an increase in their entry into cells.

Also, phenobarbital reduces the spread of nerve impulses and the excitability of neurons in the epileptogenic focus. He shows antagonism in relation to a number of exciting mediators.

What other properties are inherent in the pill "Paglyuferal"? The instruction says that they are able to suppress sensory areas of the cerebral cortex, reduce motor activity, inhibit cerebral functions, including the respiratory center. Also this medicine lowers the tone of the musculature of the digestive tract, it has an anticonvulsant, sedative, hypnotic and spasmolytic effect.

Features of the drug

In addition to phenobarbital, the composition of the agent under consideration includes other active components.

What is the role of caffeine in the preparation "Paglyuferal"? Instructions for use indicate that the substance is capable of increasing the reflex excitability of the spinal cord, excite the vasomotor and respiratory centers, stimulate metabolic processes in tissues and organs, including the musculature and the central nervous system.

Papaverine hydrochloride is an antispasmodic. It has an antihypertensive effect. This component in the drug reduces tone and relaxes the smooth muscles of blood vessels and internal organs.

Calcium gluconate is able to replenish the lack of calcium ions, which are extremely necessary for the transmission of nerve impulses.

As for bromizoval, it has a mild sedative and sedative effect.

Kinetic properties

Is the drug "Paglyuferal-1" absorbed into the total bloodstream? Instructions for use indicate that each active component of this drug has its own kinetic features.

• Phenobarbital is absorbed completely, but slowly (within 1-2 hours). Its metabolism is carried out in the liver. The half-life of this component is 2-5 days. It is excreted from the body by the kidneys.
• Caffeine is absorbed fairly well throughout the intestine. The maximum concentration of this substance is reached after a lapse of 50-75 minutes. It is metabolized in the liver, and is excreted through the kidneys.
• The average bioavailability of papaverine is 54%. With plasma proteins, it binds up to 90%. Metabolism occurs in the liver, and is excreted by the kidneys.
• About 1/5 of the dose of calcium gluconate absorbed is absorbed in the small intestine. Approximately 20% of this substance is excreted through the kidneys, and the rest - along with feces.

Indications

At what diseases are prescribed such a drug as "Paglyuferal-2"? Instruction for use states that this drug is intended for the treatment of epilepsy.

Contraindications

What are the contraindications for the drug "Paglyuferal"? Instructions for use (for newborns this tool is not prescribed) reports the following prohibitions:

• Hyperkinesis;
• Marked hepatic and renal insufficiency;
• Myasthenia gravis;
• Drug dependence;
• depression;
• Severe anemia;
• Hyperthyroidism;
• Porphyria;
• Active alcoholism;
• diabetes;
• pregnancy;
• Hypofunction of the adrenal glands ;
• Lactation period;
• Bronchial obstructive diseases;
• Hypersensitivity.

Anti-epileptic agent in tablets is prescribed for children from three years of age. With caution, it is recommended to people with a weakened condition (general).

The preparation "Paglyuferal": instructions for use

The medicament in question is taken orally after ingestion. Its dosage depends on the form of release.

Preparations "Paglyuferal-1" and "Paglyuferal-2" are taken twice a day ":

• In 3-4 years - 1 tablet;
• In five to six years -1.5 tablets;
• In seven-nine years - 2 pieces;
• In ten-fourteen years - 3 and 2.5 pcs. respectively;
• From fourteen years - 4 pcs.

The drug "Paglyuferal-3" is also taken twice a day:

• In seven to nine years - 1 tablet twice a day;
• In ten-fourteen years - 1,5 tablets;
• From fourteen years - 2 pcs.

Side effects

Taking this medication can cause:

• Hallucinations, weakness, dizziness, nystagmus, ataxia, dysarthria, sleep disorders, paradoxical reactions;
• Constipation, nausea, diarrhea, increased activity of hepatic transaminases, vomiting;
• Thrombocytopenia, agranulocytosis, megaloblastic anemia;
• Tachycardia, changes in blood pressure, extrasystole, arrhythmia, AV blockade;
• Systemic allergic reactions, drug dependence (with long-term admission).

Signs of an overdose

Elevated doses of the drug may cause an increase in adverse reactions. To eliminate such signs apply:

• Gastric lavage;
• Symptomatic therapy;
• Reception of activated carbon.

Drug Interactions

Treatment with valproate and "Phenytoin" increases the level of serum phenobarbital.

"Paglyuferal" is able to inhibit the effect of oral contraceptives and salicylates.

When combined with "Reserpine", the effect of phenobarbital increases, and when combined with "Amitriptyline", "Diazepam", "Chlordiazepoxide", "Nialamide" and "Acetazolamide" - decreases.

The drug "Paglyuferal" reduces the level of GCS in the blood, as well as indirect anticoagulants, "Doxycycline", "Griseofulvin", estrogens and other agents that are oxidized in the liver.

This drug inhibits the effect of sulfonamides, antibacterial activity and antifungal effects of Griseofulvin. In addition, it potentiates the effects of neuroleptics, ethanol, narcotic analgesics, muscle relaxants, hypnotics and sedatives.

Reviews and Analogues

According to specialists, the drug in question has no analogues, similar in composition. Therefore, to replace it, the patient should consult an experienced doctor.

Consumers claim that it will not be possible to purchase this medication without a medical prescription, although it is quite affordable.

People who have systematically taken this antiepileptic remedy note its positive effect. However, some of them still complain of the occurrence of a large number of side effects.