For what and in what dosage is the preparation "Monosan" prescribed? Instructions for the use of this vasodilator are described in detail in the materials of this article. Also in it are analogues of the drug, its composition, pharmacological action, contraindications, adverse reactions, etc.
Form, packaging, composition
What substances are included in the drug "Monosan"? The instruction says that the active element of this drug is isosorbide-5-mononitrate. The medicament also includes such auxiliary components as talc granular lactose, magnesium stearate, microcrystalline cellulose and corn starch.
In what form do manufacturers produce the drug "Monosan"? Instructions for use say that such a medicine can only be bought in the form of tablets. They are white in color and round in shape. On one side of the pill there is a risk.
The drug is packed in blisters, which are in a pack of cardboard.
How does the "Monosan" drug work? Instructions for use indicate that this drug is a peripheral vasodilator, which affects mainly the venous vessels.
The medication is capable of stimulating the production of such a relaxing endothelial factor as nitric oxide in the vascular endothelium. As a result of this influence, activation of guanylate cyclase (intracellular enzyme) occurs, which by itself leads to an increase in the vasodilating mediator - cyclic guanosine monophosphate.
After taking the drug, the need for myocardial cells in oxygen decreases. This is due to a decrease in post-and pre-load indicators.
Also, a pronounced coronary dilating action of the drug was recorded by specialists.
Effects of the drug
What other properties does the "Monosan" medication have? The use of this drug helps to reduce the flow of blood to the right atrium, which significantly reduces the pressure in a small circle of circulation and reduces the severity of negative symptoms in pulmonary edema.
It should also be noted that under the influence of "Monosan" in areas with deteriorated blood circulation there is a redistribution of coronary blood flow
Against the background of taking the drug in people suffering from angina and ischemic heart disease, resistance to any physical stresses increases significantly. In addition, the agent under consideration is capable of lowering the indices of intra-platelet synthesis of Tx and inhibiting platelet aggregation.
Where is the drug "Monosan" absorbed, distributed and metabolized? Instruction for use states that the active substance of the drug is quickly and completely absorbed from the digestive tract. After taking the pill, the antianginal effect is observed after about 30-45 minutes and lasts for 10 hours.
According to experts, the drug "Monosan" has a fairly high rates of bioavailability (about 99-100%). This is due to the lack of a first pass of the drug through the hepatic system.
The half-life of the drug is 60 minutes. The concentration of the drug in the blood varies insignificantly and depends on the individual characteristics of the organism.
The metabolism of the active substance of the drug is carried out in the liver. As a result of metabolic processes, three components are formed: isosorbide and two glucuronides of isosorbide-5-mononitrate.
The half-life of the drug is 4-5 hours. At the same time, 2.2% is excreted through the renal system, and 97.8% - in the form of glucuronic metabolites.
Indications for use
Under what conditions is Monosan appointed? The use of this drug is most effective in the following cases:
- Pulmonary hypertension, pulmonary heart;
- Heart failure of chronic form;
- Prevention of angina attacks in people with ischemic heart disease.
Contraindications for use
Under what conditions can not use "Monosan"? Analogues and the aforementioned means are forbidden to take at:
- Cardiovascular collapse;
- Shock state;
- Arterial hypovolemia and arterial hypotension;
- Cardiac tamponade ;
- Left ventricular failure and low diastolic blood pressure;
- Toxic pulmonary edema;
- Acute stage of myocardial infarction (with pronounced hypotension);
- The closed-angle form of glaucoma;
- Diseases that cause a rise in intracranial pressure;
- Individual hypersensitivity;
- In childhood and adolescence (before adulthood).
It should also be noted that the agent in question has relative contraindications. These include the following states:
- Mitral stenosis ;
- Constrictive pericarditis;
- elderly age;
- Orthostatic disorders of vascular regulation;
- Failure of the renal system;
- Hypertrophic cardiomyopathy;
- Hepatic insufficiency ;
- Aortic stenosis;
- Severe anemia.
"Monosan" preparation: instructions for use
The INN (international nonproprietary name) of this drug sounds like "isosorbide mononitrate". This drug is prescribed only orally. According to the instructions, it should be swallowed whole and washed down with water.
Prescribe the pill should only a doctor. At the same time, he must assess the severity of the underlying disease of his patient.
Treatment "Monosan" begins with taking 10-20 mg of the drug 1-3 times a day. With 3-4 days of therapy, the dosage regimen should be adjusted. If necessary, the amount of the drug is increased to 20-40 mg and taken twice a day.
What signs of an overdose may occur in a patient with an incorrect intake of Monosan? Instructions for use indicate the following symptoms: collapse, syncope, diarrhea syndrome, dizziness, hyperpnoea, reddening of the skin, methemoglobinemia, dyspnoea, tachycardia of reflex origin, headaches, hyperthermia, inhibition, weakness, increased intracranial pressure, visual disorders, seizures, Paralysis, nausea, coma, increased sweating, vomiting.
As treatment for such conditions, manipulations for gastric lavage are used, and enterosorbent agents are also prescribed.
Does the drug Monosan cause unwanted reactions? Instructions for use (analogs of this medication are indicated below) states that such a drug can cause many side effects. Let's mention some of them:
- Burning sensation in the tongue;
- Dry mouth;
- Feeling of heat;
- Nitrate headaches;
- Hyperemia of the skin ;
- Marked decrease in blood pressure;
- Increased frequency of anginal attacks;
- Orthostatic collapse ;
- Increased drowsiness;
- Slowing of mental and motor reactions;
- Blurred vision;
- Establishment of tolerance;
- Specific skin rashes;
- Exfoliative dermatitis.
Analogues of the drug and its price
What means can I replace the "Monosan" medication? There are analogues of this medicine in every pharmacy. Among the most effective are Monochinkwe, Isoket, Kardiket, Efoks, Pektrol.
As for the price of the drug, it is not very high. You can buy medicine in Russian cities for only 100 rubles (30 tablets).
The preparation we are considering has many positive reviews. Patients claim that it manifests itself as a very effective remedy for pulmonary hypertension and chronic heart failure. However, it should be noted that to obtain a high therapeutic result, this drug must be combined with other drugs. To do this, you should always contact your doctor.
I also want to note that many patients are pleased with the price of the medication presented. As it was said above, for 30 tablets you will have to give only 100 Russian rubles.
One can not help saying that this drug is often left with negative feedback. In most cases, they are associated with a variety of side effects. By the way, when they arise from taking the drug, it is better to refuse and replace it with a safer means. How, you can tell only an experienced specialist.