"Ketorolac" injections: instruction manual, reviews, analogs

"Do not complain about pain - that's the best medicine." These words belong to Omar Khayyam. It is likely that this is the case when it comes to mental suffering. If we are talking about the diseases of the body, you do not need to complain, you need to help your body. One of the most effective painkillers at the moment are injections of Ketorolac. Instructions for use contain the most complete information about this medication.

Composition and pharmacodynamics

Medication belongs to non - steroidal anti - inflammatory drugs. It is a derivative of pyrrolizine-carboxylic acid. The main active ingredient is ketorolac tromethamine (1 ml of the solution contains 30 mg), as auxiliary substances such as disodium salt and sodium chloride, ethylenediaminetetraacetic acid, ethyl alcohol rectificate, tromethamine.

Anesthetic injections "Ketorolac" show a pronounced analgesic effect. Characteristic for this drug is also an anti-inflammatory effect and a moderate antipyretic effect.

The mechanism of action is based on the suppression of COX activity. This is the main enzyme of arachidonic acid, which in turn is a precursor of prostaglandins, playing the "main violin" in the pathogenesis of inflammatory processes, pain and fever.

"Ketorolac" (injections) reviews of medical workers on the strength of analgesic effects are considered comparable with morphine and significantly superior to other NSAIDs.

Indications for use

The main area of application of this drug is pain syndromes with moderate or severe severity. A medication for symptomatic therapy is used to reduce pain and inflammation at the time of admission. On the progression of the disease has no effect.

Assign this tool in cases of postpartum and postoperative pain. Effectively give in to treatment with these injections and joint pain, triggered by trauma and rupture of ligaments, toothache.

Also, the "Ketorolac" shots are recommended for use in the treatment of dislocations, sprains, muscle pains and back pain. Appoint this medicine for cancer, myalgia, arthralgia, neuralgia.

Contraindications for use

Do not use the drug to treat those patients who have a hypersensitivity to any of the components. The basis for refusal is also the presence of an "aspirin triad" and hypovolemia (the cause that provoked the disease is not important). Also, "Ketorolac" (injections and pills) are not prescribed to those who have any erosive and ulcerative gastrointestinal lesions in acute stage.

These injections should not be used to treat those who suffer from hemophilia, hypocoagulation and are subject to bleeding or a high risk of their development.

Also, the contraindication is the presence of severe forms of renal and hepatic insufficiency.

Do not prescribe Ketorolac immediately after aortocoronary shunting, during the 3rd trimester of pregnancy, during labor and lactation. Contraindicated to injections of children under 16 years.

Application and dosing

The dose for injection is selected individually, based on the severity of the pain syndrome. Injections "Ketorolac" instructions for use allow you to enter in / m and / in. With the intramuscular method, the single volume is 10 to 30 mg. The interval between the procedures should not be less than 4-6 hours. The maximum course of therapy is 5 days.

The daily dose at the / m introduction is 90 mg. However, for patients weighing up to 50 kg, for those with impaired renal function and for patients older than 65 years, the dosage should not exceed a volume of 60 mg.

To strengthen the analgesic effect, often prescribed for taking injections and tablets "Ketorolac" in the complex.

Pregnancy, childbirth and lactation: is it permissible to use Ketorolac?

Injections "Ketorolac" instructions for use prohibit the use for the treatment of pregnant women. The use of this medication is possible only for life indications, when the expected positive effect for the mother exceeds the potential risk for the baby.

If, for any reason, there is a need to be treated with Ketorolac during lactation, it is necessary to discuss with the doctor the question of the refusal of breastfeeding.

Medical specialists also do not recommend the use of Ketorolac for premedication, which supports anesthesia and anesthesia of labor, since this medicine can prolong the course of the first period of labor. In addition, "Ketorolac" can depressingly affect uterine contractility and blood circulation of the child.

Possible undesirable manifestations

Side effects on injections "Ketorolac", the use of which was described above, are also quite diverse and can follow from a variety of body systems. The gastrointestinal tract most often can react with the development of diarrhea and the appearance of symptoms of gastralgia. Less often you can hear about constipation, vomiting, flatulence, the development of ulcerative foci.

The urinary system reacts to Ketorolac quite rarely, but here one can also hear about hematuria, pain in the lower back, nephritis and edema of kidney genesis.

Respiratory organs (bronchospasm, rhinitis, pulmonary and laryngeal edema) and sensory organs (visual impairment, deterioration of auditory perception, ringing in the ears) also rarely enough in response to injections.

Often patients talk about the reaction of the central nervous system to "Ketorolac", manifested by drowsiness, dizziness, headaches. Less often you can hear about the symptoms of aseptic meningitis and hyperactivity, about the appearance of psychoses and hallucinations.

From time to time, there is information about unwanted manifestations of the cardiovascular system (increased blood pressure), hematopoiesis system (leukopenia, anemia), hemostasis systems (bleeding - nasal, rectal, postoperative).

Often patients talk about the appearance of edema of the face, shins, ankles, fingers, weight gain, increased sweating.

Exceeding the permissible dose

Symptomatic overdosage for the drug "Ketorolac" (a prick in a vein or intramuscularly made once) is most often expressed in pain in the abdomen, in nausea and vomiting. Also, patients and health workers talk about possible erosive and ulcerative lesions of the digestive tract, abnormalities in the functioning of the kidneys, metabolic acidosis (it develops due to the accumulation of acid products in the tissues, insufficient binding or destruction).

Therapy in such cases is symptomatic and is aimed at maintaining important body functions. Hemodialysis does not have a significant effect.

What should I look for?

Before starting treatment with Ketorolac, it is important to find out if there have been previously reported cases of allergic manifestations on medication or other NSAIDs. The first injection is desirable to be performed in the presence of a doctor (to avoid the manifestation of allergies).

If there is such a need, you can apply "Ketorolac" (injections) in combination with narcotic analgesics. Patients suffering from abnormalities in blood clotting, "Ketorolac" are prescribed for use only with the condition of constant monitoring of the number of platelets. This is a particularly urgent issue for people who have undergone surgical intervention and who require careful monitoring of hemostasis.

In people with chronic diseases and pain, an increase in the period of therapy can lead to the development of drug complications.

In the process of treatment with Ketorolac, it is important to be cautious when managing road transport and to avoid potentially dangerous types of work related to increased attention and increased speed of psychomotor reactions.

Interaction with other drugs

Parallel reception of "Ketorolac" with paracetamol increases the nephrotoxicity of the first. Often, patients are interested in the question of whether it is possible to combine injections of Diclobert and Ketorolac. The answer is negative: combining Ketorolac with any other NSAIDs increases the likelihood of ulceration of the gastrointestinal mucosa and may cause gastrointestinal bleeding.

Parallel use with anticoagulants, antiplatelet agents, valproic and acetylsalicylic acids, cephalosporins increases the likelihood of bleeding.

"Ketorolac" reduces the effectiveness of drugs that lower blood pressure, and diuretics. "Methotrexate" increases hepato- and nephrotoxicity of "Ketorolac". The same effect will be with parallel reception with any other nephrotoxic drugs. Medications blocking tubular secretion, reduce the clearance of "Ketorolac" and thereby increase its concentration in the plasma.

In addition, injections of "Ketorolac" increase the effectiveness of analgesics of narcotic type.

Medicaments - analogues and price range

A fairly large number of similar drugs on the human body is available for the drug Ketorolac (injections). Instructions for use analogues describes for each form of release, i.e. for injections, and for tablets. Among the most known and popular injectable solutions for injection, you can specify such medications as Ketanov, Ketalgin, Ketorol, Ketofril, Ketorolac-Exmo, Ketorolac-Tromethamine, Dolak, Dolomin, Toradol.

As for the price, the cost of a package of 10 ampoules with a dosage of 30 mg / ml varies from 63 to 144 rubles.

Customer Reviews

Most consumers are very satisfied with the effect. Positive results are observed in the majority of pain sensations in which the Ketorolac treatment regimen is recommended for use. The injections of female patients are characterized as very effective in menstrual pain. In general, injections were used for dental pains, and for anesthetizing the process of stone movement in the kidneys, and in the postoperative period, and in many other cases.

The positive effect of the drug significantly eased the patients' condition, however, side effects also occurred. So, a separate group of people speaks about the appearance of skin reactions and abdominal pains. However, this does not detract from its high effectiveness as an analgesic and anti-inflammatory agent.

In addition to all the above, patients are satisfied with the price of injections of Ketorolak, which is much lower than the cost of almost all of its analogues.

Opinion of specialists

The opinions of doctors about the drug "Ketorolac" also have both positive and negative sides. The bulk of specialists believe that if you follow all the recommendations that contain the instruction for the Ketorolak (nyxes) medication, then this NSAID will perform all its functions with the proper positive effect and will not cause side effects.

The drug does not penetrate into the cerebrospinal fluid, since it is a medicament of limited effect - only in the area of inflammation. The effect of addiction is also absent.

As for negative responses from specialists, it can be said that a separate group of doctors believes that "Ketorolac" has a weak anti-inflammatory effect. Also, doctors talk about the negative effects on the pancreas (provocation of diabetes) and on the functioning of the kidneys.

In general, it can be said that following the instructions and following the recommendations of the attending doctor will make it possible to get the most positive effect from the application of Ketorolac injections without the risk of serious side effects.