Kagocel - instructions for use.

Dosage form

The preparation is supplied in the form of round biconvex tablets, cream colored, containing kagocel. Instruction for use contains the following data on the composition of the drug:

Composition:

• Kagocel - 12 mg / tab.

Excipients - calcium stearate, potato starch, lupus, lactose monohydrate, povidone, crospovidone.

Pharmacological action of milgamma preparation

For this drug Kagocel instructions for use contains comprehensive data on the pharmacological effect. The drug causes the formation of late interferon, which is a combination of alpha and beta interferons, which have a sufficiently high activity in the fight against viruses. Kagocel can cause an increase in the synthesis of interferon in almost all types of cells that participate in the antiviral response - macrophages, fibroblasts, T and B lymphocytes, granulocytes, endothelial cells.

Its maximum values of interferon titer reaches after applying a single dose of the drug within 48 hours. In addition, after taking this medication, the increased interferon titer circulates in the blood long enough, up to 5 days in order to provide the necessary antiviral support to the body. Achieving the maximum concentrations of interferon in the gastrointestinal tract, in particular in the intestine, does not coincide with the values of reaching the maximum concentration of interferon in the blood, since in the first case the maximum is noted about four hours after the drug has entered the digestive tract, and in the second, only through two days.

Kagocel, which will be administered in therapeutic doses, does not pose a danger to the body, since it is non-toxic and practically not accumulated in it. In addition, the drug has no teratogenic and mutagenic properties, is not carcinogenic and has no embryotoxic effect.

Pharmacokinetics

Pharmacokinetics of the drug Kagocel. The instructions for use say that since the drug is taken orally, only about 20% of the drug enters the bloodstream from the entire administered dose. A day after the drug was taken, it begins to accumulate more in the liver, in less - in the thymus, lungs, kidneys, spleen and lymph nodes. A very low concentration of the drug is noted - in the heart, fat tissue, testes, blood plasma, brain. A fairly low concentration of the drug in the brain can be explained by the fact that it has a high molecular weight. In plasma, the drug is mostly in a bound form - associated with proteins about 37%, associated with lipids about 47%. Thus, only 16% remains in the free form.

The drug is mostly excreted through the intestines, after a week at 88% of the entire administered dose, and about 90% of them are excreted with feces, and 10% with urine. In the air, which is exhaled, the drug is not detected.

Indications for taking the drug

• Treatment of influenza and ARI in adult patients
• Prevention of influenza and ARI in adult patients
• Treatment of influenza and ARI in children from 6 years old
• Prevention of influenza and acute respiratory infections in children aged 6 years
• Treatment of herpes in older age groups

Side effects

The cause of individual allergic reactions may become Kagocel, the summary of the drug does not contain other side effects.

Contraindications

• Age to 6 years
• Pregnancy and lactemia
• Individual hypersensitivity

Kagocel dosage regimen, instructions for use

How to take Kagocel - a dosage regimen for adults and children is recommended to check with your doctor.

Overdose

In case of an overdose of a medicinal product, it is necessary to give the victim plenty of drink and necessarily cause vomiting in him.

Drug Interactions

There is an additive effect when using Kagocel and other antiviral drugs, antibiotics and modulators.