Description of the drug "Vikeira Pak". Reviews of the treated, the use of Viekira Pak

The drug of the new generation from hepatitis C "Wikeyra Pak" reviews treated in most positive cases. This is due primarily to the high efficacy of the drug.

The action of the drug "Vikeira Pak"

The action of the drug is based on three preparations of the antiviral type. These are Dasabuvir, Ombitasvir, and ritonavir-boosted Paritaprevir. Like the world-famous drug called "Harvoni", "Viqueira Pak" has a high efficiency of treatment - an interval of 97 to 99%. The drug from hepatitis is the fourth approved in America. Prior to it, clinical tests successfully passed "Olizio" (the name in Russia is "Sovriad"), combined "Harvoni", and also "Sowaldi".

General information about a new generation medical product

"Vikeira Pak" (the reviews were not very numerous, since the drug was registered in Russia only in May 2015) is produced by the Irish producer, but is packaged in the United States of America. The drug in Russia is sold officially, it can be ordered at any pharmacy. Active active substances of the drug:

• Ritonavir;
• Dasabuwir;
• Paritrapeprir;
• Ombitasvir.

Refers to antiviral drugs of direct action (J05A). This medication is an expensive drug. For example, the course of treatment for 12 weeks will cost 950 thousand rubles - a few packs of funds "Vikeira Pak" (the cost in St. Petersburg). Customer reviews include information that, compared to the famous "Harvoni", whose price in Europe is about 60 thousand dollars, the Irish drug is still quite available for purchase. The most budgetary option among all is a similar drug called "Sunvepra" (the price is 400 thousand rubles for a course of treatment of the same duration).

Terms and conditions of storage

Full description of the drug "Vikeira Pak" can be read on the package with the medicine. Keep it in a place inaccessible to children at a temperature of not more than 25 degrees Celsius. Do not take the drug after the expiry date is 2 years. All information about the "Vikeira Pak" means: price, instructions for use, reviews of people undergoing treatment with this medication, is summarized in this article.

The application of "Vicair Park" and side effects

Admission of the drug in question for the treatment of hepatitis C should be done during meals, while the caloric content or fat content of the products do not matter. In the morning, two tablets of paritrapeprir / ritonavir / ombitasvir, plus one dasabuwir pill should be taken. The latter must be used in the evenings. To some patients, the doctor appoints the "Vicair Park" in combination with "Ribavirin". If this particular therapy is chosen, the "Wikeyra Pak" is taken in the amount of six tablets per day:

• In the morning time of day - one dark tablet and two light;
• In the evening one is dark;
• Twice a day, "Ribavirin" in a dosage of 500 mg.

The application of "Vikeira Pak" (reviews including comments of experienced specialists) must be agreed with the doctor without fail. If the patient suffers from co-infection with HIV, then the drug regimen remains the same, plus, necessarily - during meals. On the package there are no serious side effects from taking the medication. The most common possible deviations, judging by the feedback and instructions, are:

• asthenia;
• Reactions of the skin, including itching;
• fast fatiguability;
• Lack of sleep;
• nausea.

Scheme of treatment course

For the "Vichera Pak" preparation, the treatment regimen includes a combination of three medicines developed by the company "EbbVay", plus a pharmacokinetic-type enhancer called "Ritonavir". The drug regimen for the treatment of hepatitis C is prescribed for HCV therapy (genotype 1a) in combination with Ribavirin. The course should be no less than 12 full weeks. For genotype 1b, treatment is similar, but without including the last drug. In addition, "Vikeira Pak" (reviews treated by the scheme look more than impressive) is intended for the treatment of patients with compensated cirrhosis. The course is 24 weeks with "Ribavirin" for genotype 1a, in other cases - 12 weeks.

A stable virologic response in patients (with genotype 1a) with absence of cirrhosis was achieved in 97% of cases, and at 1b - 100% with a note that the therapy was of a combined type. With compensated cirrhosis of the liver, the SVR reached 95% (the therapy lasted 24 weeks) for genotype 1a, in other cases (1b) the mark approached a hundred percent.

Existing contraindications

The drug "Vikeira Pak" (reviews treated this confirm) has, like any drug, a number of contraindications. These include the following:

• Decompensation of hepatic function;
• Hypersensitivity to ritonavir;
• Hemoglobinopathy;
• Simultaneous therapy with "didanosine";
• pregnancy;
• Taking strong inhibitors;
• Reception of strong inducers.

It should be noted that the use of a medical product for children under the age of majority is strictly prohibited. In addition, during lactation, a course of treatment for a woman is also not recommended because of the lack of accurate information about the penetration of active substances of "Viqueira Pak" into breast-milk. It is necessary to stop breastfeeding.

Caution in applying

The American Office of Quality Control of Medicines reports that Vikeira Pak and analogs that are used to treat hepatitis C can lead to irreparable liver damage. Especially it concerns people with deviations in the work of a vital organ. For this reason, the manufacturer has made certain amendments to the instruction for the use of the medicinal product.

If the patient observes that frequent fatigue and fatigue occur during the treatment, dizzy, often vomiting and vomiting, and the skin begins to yellow, it is necessary to seek help from a specialist because there is a possibility of liver damage. To stop taking the drug without consulting with a doctor is in no case possible, as this can lead to the emergence of resistance to other drugs that fight with hepatitis. The doctor in the hospital should observe the patient for some time to exclude signs of a disruption in the liver. These include:

• Bleeding from the esophageal dilated veins;
• Ascites;
• Increased bilirubin levels;
• Encephalopathy.

Such drugs as "Vikeira Pak", contribute to a significant reduction in the amount of hepatitis C virus in the human body, in addition, can slow the progression of the disease.

The appointment of patients with a new drug from hepatitis C

Features of Viekira Pak treatment include a combination of certain doses of several drugs that are used in combination with "Ribavirin" or without. The drug was approved for the treatment of patients suffering from cirrhosis of the liver and chronic hepatitis C. Before using this medication, it is necessary to inform the doctor about the following:

• On the presence of HIV infection;
• About other liver diseases, in addition to hepatitis C;
• On the use of contraceptives, including ethinyl estradiol.

It should be noted that in most cases, side effects from taking the drug are itching and irritation of the skin, lack of sleep and the urge to vomit. According to data from 2015, health professionals have prescribed a drug called "Viqueira Pak" for more than 11,000 people.

What should every patient who is undergoing treatment know?

If the patient undergoes a 12- or 24-day course of treatment, it can not be stopped without consulting the doctor. This can lead to the emergence of resistance of the body to other medicines-analogues. It is worth remembering that if a patient has an advanced stage of liver pathology, then "Vichera Pak" can lead to a serious organ damage, including hepatic insufficiency. Be sure to seek help in the hospital if you see a regular recurrence of symptoms such as vomiting, yellowing of the sclera, a sharp unexplained loss of appetite, feces of light color.

Before starting a course of treatment, it is recommended that you read the instructions. Any questions should be discussed with your doctor. You can not withhold any information about your health, including the resulting side effects from taking the Vikaira Pak.

Safety assessment

The safety of the Vikaira Pak drug was evaluated based on the data of the second and third phase of clinical trials in almost 3,000 patients undergoing treatment in combination with Ribavirin and without. Data were also taken into account among patients suffering from cirrhosis of the liver. Adverse reactions from the use were observed in 20% of cases. The most frequent signs are nausea and severe fatigue. Discontinued treatment due to side effects of only 1.15%. Resumed course after interruption of therapy - 1.4%. Because of the negative reactions of the body to the drug, it was necessary to reduce the dosage of "Ribavirin" in 8% of patients.

Differences in the response of the body to the drug in patients with cirrhosis and without it was not observed. The clinical study involved patients who took Vikaira Pak and without Ribavirin. The noted only reaction to the drug in this case is the occurrence of itching on the skin. Stopped treatment for this reason, only 0.4%, a break in therapy made about 0.6% of patients. Evaluation of the safety of the drug "Vikeira Pak" was conducted on several parameters (with cirrhosis and without, with the addition of "Ribavirin" and no) and throughout the therapeutic course, that is 12 weeks and 24.

Approximate cost of "Vikeira Pak" in Russia and abroad

In the United States, Vikeira Pak costs about $ 84,000 (including a 12-day course of treatment), the price policy in the Russian Federation, like in many other European countries, is significantly different.

At various portals on the Internet you can see the different costs of an Irish medical product. For medical institutions in Russia, the cost of "Vikeira Pak" is about 300 thousand rubles for one month of treatment. For a 12-week course, you will have to pay about 850-900 thousand rubles. Thus, those who are prescribed therapy in 24 weeks, will need to buy a cure for hepatitis C not less than 1.5 million rubles.